About: Effect of two glycyrrhizinic acid nanoparticle carriers on MARC-145 cells actin filaments

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About: Effect of two glycyrrhizinic acid nanoparticle carriers on MARC-145 cells actin filaments Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Effect of two glycyrrhizinic acid nanoparticle carriers on MARC-145 cells actin filaments
Creator	David Quintanar, · García, Carlos Jardon, Samantha María De Lourdes Juárez, · Mendoza, Susana Nieto, José
Source	Medline; PMC
abstract	The development of technologies that combine the advantages of nanomedicine with natural medicine represents a versatile approach to improve the safety and efficacy of drugs. Glycyrrhizinic acid (GA) is a natural compound that has a wide range of biological activities for the treatment of diseases. To establish a safe nanotransport system for this drug, two different nanoparticles with glycyrrhizinic acid, solid lipid nanoparticles (SLN–GA) and polymeric nanoparticles (PNP(S)–GA) were elaborated to obtain nanostructure sizes between 200 and 300 nm. The nanoparticles were evaluated at concentrations of 1.25–100 μl/ml using the MARC-145 cell line to determine the effects on cell morphology, cellular structure (actin filaments) and cell viability (mitochondrial and lysosomal) at 24 and 72 h post-exposure. The safety range of the nanoparticles was 50 µl/ml, to determine that PNPs–GA had an optimal safety profile and no cytotoxic effects, as there was no evidence of changes in morphology, internal cellular structures (stress fibers and the cell cortex formed by actin filaments) or viability under the experimental concentrations and conditions employed.
has issue date	2018-04-13(xsd:dateTime)
bibo:doi	10.1007/s13204-018-0758-0
bibo:pmid	32226703
has license	no-cc
sha1sum (hex)	9c315d087e5ac771590313c7dfa9fb129b501add
schema:url	https://doi.org/10.1007/s13204-018-0758-0
resource representing a document's title	Effect of two glycyrrhizinic acid nanoparticle carriers on MARC-145 cells actin filaments
has PubMed Central identifier	PMC7096899
has PubMed identifier	32226703
schema:publication	Appl Nanosci
resource representing a document's body	covid:9c315d087e5ac771590313c7dfa9fb129b501add#body_text
is schema:about of	named entity 'CARRIERS' named entity 'lipid' named entity 'carriers' named entity 'acid' named entity '200' named entity 'BCL' named entity 'LIPID' named entity 'ON CELL' named entity 'APPROACH' named entity 'CELL CORTEX' named entity 'NANOMEDICINE' named entity 'CHANGES' named entity 'NATURAL MEDICINE' named entity 'PROFILE' named entity 'WIDE' named entity 'DRUG' named entity 'SOLID' named entity 'EFFICACY' named entity 'EMPLOYED' named entity 'USING' named entity 'EXPERIMENTAL' named entity 'ACTIN FILAMENTS' named entity 'CONDITIONS' named entity 'BIOLOGICAL' named entity 'ESTABLISH' named entity 'LYSOSOMAL' named entity 'CELL MORPHOLOGY' named entity 'NANOPARTICLES' named entity 'SAFE' named entity 'GLYCYRRHIZINIC ACID' named entity 'FIBERS' named entity 'TECHNOLOGIES' named entity 'NO EVIDENCE OF' named entity 'EFFECTS' named entity 'MORPHOLOGY' named entity 'CELL VIABILITY' named entity 'TREATMENT' named entity 'EVALUATED' named entity 'INTERNAL' named entity 'SIZES' named entity '100' named entity 'POLYMERIC' named entity 'IS A' named entity 'OPTIMAL' named entity 'COMBINE' named entity 'GLYCYRRHIZINIC ACID' named entity 'CELLS' named entity 'OBTAIN' named entity 'CONCENTRATIONS' named entity 'MARC' named entity 'ACTIN FILAMENTS' named entity '145' named entity 'DETERMINE' named entity 'DEVELOPMENT' named entity 'CELL LINE' named entity 'CELLULAR STRUCTURE' named entity 'FILAMENTS' named entity 'THE CELL' named entity 'DISEASES' named entity 'SAFETY' named entity 'DRUGS' named entity 'CELLULAR STRUCTURES' named entity 'DIFFERENT' named entity 'EFFECT' named entity 'EXPOSURE' named entity 'NANOSTRUCTURE' named entity 'NATURAL COMPOUND' named entity 'MARC' named entity 'VIABILITY' named entity 'NANOPARTICLE' named entity 'SYSTEM' named entity 'RANGE' named entity 'POST' named entity '1.25' named entity '145' named entity 'FORMED'

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