About: A CRISPR toolbox to study virus

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About: A CRISPR toolbox to study virus–host interactions Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	A CRISPR toolbox to study virus–host interactions
Creator	Puschnik, Andreas Majzoub, Karim Carette, Jan Ooi, Yaw
Source	Medline; PMC
abstract	Viruses depend on their hosts to complete their replication cycles; they exploit cellular receptors for entry and hijack cellular functions to replicate their genome, assemble progeny virions and spread. Recently, genome-scale CRISPR–Cas screens have been used to identify host factors that are required for virus replication, including the replication of clinically relevant viruses such as Zika virus, West Nile virus, dengue virus and hepatitis C virus. In this Review, we discuss the technical aspects of genome-scale knockout screens using CRISPR–Cas technology, and we compare these screens with alternative genetic screening technologies. The relative ease of use and reproducibility of CRISPR–Cas make it a powerful tool for probing virus–host interactions and for identifying new antiviral targets.
has issue date	2017-04-19(xsd:dateTime)
bibo:doi	10.1038/nrmicro.2017.29
bibo:pmid	28420884
has license	green-oa
sha1sum (hex)	9c39d4edcd259aaf2d64858e826f2f7a70a23a79
schema:url	https://doi.org/10.1038/nrmicro.2017.29
resource representing a document's title	A CRISPR toolbox to study virus–host interactions
has PubMed Central identifier	PMC5800792
has PubMed identifier	28420884
schema:publication	Nature Reviews Microbiology
resource representing a document's body	covid:9c39d4edcd259aaf2d64858e826f2f7a70a23a79#body_text
is schema:about of	named entity 'probing' named entity 'functions' named entity 'West Nile virus' named entity 'study' named entity 'WEST NILE VIRUS' named entity 'NEW' named entity 'DISCUSS' named entity 'THESE' named entity 'HOST' named entity 'COMPLETE' named entity 'PROBING' named entity 'INTERACTIONS' named entity 'USE' named entity 'CAS' named entity 'GENOME' named entity 'SCALE' named entity 'MAKE' named entity 'REPLICATE' named entity 'ANTIVIRAL' named entity 'PROGENY' named entity 'COMPARE' named entity 'KNOCKOUT' named entity 'FUNCTIONS' named entity 'RELATIVE' named entity 'VIRIONS' named entity 'EASE' named entity 'VIRUS' named entity 'ACCESS' named entity 'GENETIC SCREENING' named entity 'EXPLOIT' named entity 'USED' named entity 'RELEVANT' named entity 'HAVE' named entity 'THEIR' named entity 'REPLICATION' named entity 'RECEPTORS' named entity 'ZIKA VIRUS' named entity 'TECHNOLOGY' named entity 'POWERFUL' named entity 'REPRODUCIBILITY' named entity 'VIRUS' named entity 'ENTRY' named entity 'CELLULAR' named entity 'SPREAD' named entity 'CRISPR' named entity 'HOST' named entity 'HHS' named entity 'TOOL' named entity 'ASSEMBLE' named entity 'IDENTIFYING' named entity 'VIRUS REPLICATION' named entity 'USING' named entity 'VIRUSES' named entity 'TARGETS' named entity 'DENGUE VIRUS' named entity 'TECHNICAL' named entity 'DEPEND' named entity 'TO IDENTIFY' named entity 'INTERACTIONS' named entity 'PUBLIC' named entity 'STUDY' named entity 'CRISPR' named entity 'REVIEW' named entity 'HEPATITIS C VIRUS' named entity 'INCLUDING' named entity 'ALTERNATIVE' named entity 'RECENTLY' named entity 'REQUIRED' named entity 'HOSTS' covid:arg/9c39d4edcd259aaf2d64858e826f2f7a70a23a79 named entity 'screens' named entity 'exploit' named entity 'replication' named entity 'host' named entity 'cellular' named entity 'viruses' named entity 'virus replication' named entity 'hepatitis C virus'

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