About: Vitamin A deficiency impairs the immune response to intranasal vaccination and RSV infection in neonatal calves

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About: Vitamin A deficiency impairs the immune response to intranasal vaccination and RSV infection in neonatal calves Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Vitamin A deficiency impairs the immune response to intranasal vaccination and RSV infection in neonatal calves
Creator	Henningson, Jamie Narasimhan, Balaji Guerra-Maupome, Mariana Winkley, Emma Kelly, Sean Sacco, Randy Mcgill, Jodi
Source	PMC
abstract	Respiratory syncytial virus (RSV) infection is a leading cause of severe acute lower respiratory tract infection in infants and children worldwide. Vitamin A deficiency (VAD) is one of the most prevalent nutrition-related health problems in the world and is a significant risk factor in the development of severe respiratory infections in infants and young children. Bovine RSV (BRSV) is a primary cause of lower respiratory tract disease in young cattle. The calf model of BRSV infection is useful to understand the immune response to human RSV infection. We have previously developed an amphiphilic polyanhydride nanoparticle (NP)-based vaccine (i.e., nanovaccine) encapsulating the fusion and attachment proteins from BRSV (BRSV-NP). Calves receiving a single, intranasal dose of the BRSV-NP vaccine are partially protected from BRSV challenge. Here, we evaluated the impact of VAD on the immune response to the BRSV-NP vaccine and subsequent challenge with BRSV. Our results show that VAD calves are unable to respond to the mucosal BRSV-NP vaccine, are afforded no protection from BRSV challenge and have significant abnormalities in the inflammatory response in the infected lung. We further show that acute BRSV infection negatively impacts serum and liver retinol, rendering even well-nourished individuals susceptible to VAD. Our results support the use of the calf model for elucidating the impact of nutritional status on mucosal immunity and respiratory viral infection in infants and underline the importance of VA in regulating immunity in the respiratory mucosa.
has issue date	2019-10-22(xsd:dateTime)
bibo:doi	10.1038/s41598-019-51684-x
bibo:pmid	31641172
has license	cc-by
sha1sum (hex)	9c3a27a40bb77b4b2663e8033413b4036b1ef43c
schema:url	https://doi.org/10.1038/s41598-019-51684-x
resource representing a document's title	Vitamin A deficiency impairs the immune response to intranasal vaccination and RSV infection in neonatal calves
has PubMed Central identifier	PMC6805856
has PubMed identifier	31641172
schema:publication	Sci Rep
resource representing a document's body	covid:9c3a27a40bb77b4b2663e8033413b4036b1ef43c#body_text
is schema:about of	named entity 'inflammatory response' named entity 'RESPONSE TO' named entity 'HAVE' covid:arg/9c3a27a40bb77b4b2663e8033413b4036b1ef43c named entity 'PROTECTION' named entity 'MUCOSAL' named entity 'SUBSEQUENT' named entity 'USE OF' named entity 'THE CALF' named entity 'RESPIRATORY VIRAL INFECTION' named entity 'OUR' named entity 'ACUTE' named entity 'BRSV' named entity 'SUSCEPTIBLE' named entity 'NUTRITIONAL STATUS' named entity 'EVALUATED' named entity 'ABNORMALITIES' named entity 'CALVES' named entity 'IMPAIRS' named entity 'RSV INFECTION' named entity 'RESPONSE TO' named entity 'SUPPORT' named entity 'LUNG' named entity 'CHALLENGE' named entity 'IMPACT' named entity 'LIVER' named entity 'RETINOL' named entity 'MODEL' named entity 'IMMUNE RESPONSE' named entity 'PARTIALLY' named entity 'VAD' named entity 'VACCINE' named entity 'REGULATING' named entity 'INFECTION' named entity 'RENDERING' named entity 'RESPOND TO' named entity 'SIGNIFICANT' named entity 'SERUM' named entity 'CALVES' named entity 'INFECTED' named entity 'HERE' named entity 'INFLAMMATORY RESPONSE' named entity 'RESPIRATORY MUCOSA' named entity 'MUCOSAL IMMUNITY' named entity 'RESULTS' named entity 'NEONATAL' named entity 'VITAMIN A DEFICIENCY' named entity 'INTRANASAL VACCINATION' named entity 'IMMUNE RESPONSE' named entity 'IMMUNITY' named entity 'INFANTS' named entity 'UNABLE TO RESPOND' named entity 'INDIVIDUALS' named entity 'nutritional status' named entity 'acute' named entity 'Our' named entity 'vaccine' named entity 'liver' named entity 'infection' named entity 'VAD' named entity 'inflammatory response' named entity 'VAD' named entity 'mucosal immunity' named entity 'respiratory mucosa' named entity 'serum' named entity 'neonatal' named entity 'RSV infection' named entity 'lungs' named entity 'retinol' named entity 'IL-13' named entity 'IL-6' named entity 'VAD' named entity 'lysis' named entity 'D 3' named entity 'liver'

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