About: Difference in immune response in vaccinated and unvaccinated Swedish individuals after the 2009 influenza pandemic

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Difference in immune response in vaccinated and unvaccinated Swedish individuals after the 2009 influenza pandemic
Creator	Maeurer, Markus Linde, Annika Ambati, Aditya Magalhaes, Isabelle Montomoli, Emanuele Alvarez-Corrales, Nancy Axelsson-Robertson, Rebecca Eriksson, Mikael Khalaj, Bahareh Lapini, Giulia Linde, Charlotte Muhammad, Rashid Rane, Lalit Pedersen, Nancy
Source	Medline; PMC
abstract	BACKGROUND: Previous exposures to flu and subsequent immune responses may impact on 2009/2010 pandemic flu vaccine responses and clinical symptoms upon infection with the 2009 pandemic H1N1 influenza strain. Qualitative and quantitative differences in humoral and cellular immune responses associated with the flu vaccination in 2009/2010 (pandemic H1N1 vaccine) and natural infection have not yet been described in detail. We designed a longitudinal study to examine influenza- (flu-) specific immune responses and the association between pre-existing flu responses, symptoms of influenza-like illness (ILI), impact of pandemic flu infection, and pandemic flu vaccination in a cohort of 2,040 individuals in Sweden in 2009–2010. METHODS: Cellular flu-specific immune responses were assessed by whole-blood antigen stimulation assay, and humoral responses by a single radial hemolysis test. RESULTS: Previous seasonal flu vaccination was associated with significantly lower flu-specific IFN-γ responses (using a whole-blood assay) at study entry. Pandemic flu vaccination induced long-lived T-cell responses (measured by IFN-γ production) to influenza A strains, influenza B strains, and the matrix (M1) antigen. In contrast, individuals with pandemic flu infection (PCR positive) exhibited increased flu-specific T-cell responses shortly after onset of ILI symptoms but the immune response decreased after the flu season (spring 2010). We identified non-pandemic-flu vaccinated participants without ILI symptoms who showed an IFN-γ production profile similar to pandemic-flu infected participants, suggesting exposure without experiencing clinical symptoms. CONCLUSIONS: Strong and long-lived flu-M1 specific immune responses, defined by IFN-γ production, in individuals after vaccination suggest that M1-responses may contribute to protective cellular immune responses. Silent flu infections appeared to be frequent in 2009/2010. The pandemic flu vaccine induced qualitatively and quantitatively different humoral and cellular immune responses as compared to infection with the 2009 H1N1 pandemic H1N1 influenza strain.
has issue date	2014-06-11(xsd:dateTime)
bibo:doi	10.1186/1471-2334-14-319
bibo:pmid	24916787
has license	cc-by
sha1sum (hex)	9c437ea3972c987ed041833f65535b2d4300e095
schema:url	https://doi.org/10.1186/1471-2334-14-319
resource representing a document's title	Difference in immune response in vaccinated and unvaccinated Swedish individuals after the 2009 influenza pandemic
has PubMed Central identifier	PMC4067073
has PubMed identifier	24916787
schema:publication	BMC Infect Dis
resource representing a document's body	covid:9c437ea3972c987ed041833f65535b2d4300e095#body_text
is schema:about of	named entity 'vaccine' named entity 'flu vaccination' named entity 'SPECIFIC' named entity 'INFLUENZA' named entity 'QUALITATIVE' named entity 'CELLULAR' named entity 'FLU' named entity 'CLINICAL SYMPTOMS' named entity 'INFECTION' named entity 'NATURAL INFECTION' named entity 'SWEDEN' named entity 'H1N1 INFLUENZA' named entity 'RESPONSES' named entity 'PREVIOUS' named entity 'COHORT' named entity 'ASSOCIATED WITH' named entity 'EXPOSURES' named entity 'ASSOCIATION' named entity 'DESCRIBED' named entity 'SYMPTOMS' named entity 'IMMUNE RESPONSES' named entity 'PANDEMIC' named entity 'HAVE' named entity 'STRAIN' named entity 'VACCINE' named entity 'LONGITUDINAL STUDY' named entity 'FLU VACCINE' named entity 'INDIVIDUALS' named entity 'INFLUENZA-LIKE ILLNESS' named entity 'SUBSEQUENT' named entity 'FLU VACCINATION' named entity 'H1N1' named entity 'TO EXAMINE' named entity 'QUANTITATIVE' named entity 'IMPACT' named entity 'PRE-EXISTING' named entity 'BACKGROUND' covid:arg/9c437ea3972c987ed041833f65535b2d4300e095 named entity '2009' named entity '2010' named entity 'flu' named entity 'pandemic' named entity 'immune responses' named entity 'symptoms' named entity 'Background' named entity 'pandemic flu' named entity 'flu' named entity 'longitudinal study' named entity 'influenza-like illness' named entity 'immune responses' named entity 'flu vaccination' named entity 'clinical symptoms' named entity 'H1N1' named entity 'immune responses' named entity 'flu' named entity 'flu' named entity 'flu' named entity 'flu' named entity 'inflammatory response' named entity 'flu' named entity 'flu vaccine' named entity 'H5N1' named entity 'A/H1N1' named entity 'flu' named entity 'flu vaccination' named entity 'A/H1N1' named entity 'flu' named entity 'humoral'

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