About: Review of trials currently testing treatment and prevention of COVID-19

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Review of trials currently testing treatment and prevention of COVID-19
Creator	Tsiodras, Sotirios Lescure, François-Xavier Yazdanpanah, Yazdan Mentré, France Skevaki, Chrysanthi Laouénan, Cédric Belhadi, Drifa Peiffer-Smadja, Nathan Fragkou, Paraskevi Janocha, Hannah Karofylakis, Emmanouil Moschopoulos, Moschopoulos, Charalampos
Source	Elsevier; Medline; PMC
abstract	BACKGROUND: As COVID-19 cases continue to rise globally, evidence from large randomised controlled trials is still lacking. Currently, numerous trials testing potential treatment and preventative options are undertaken all over the world. OBJECTIVES: We summarised all registered clinical trials examining treatment and prevention options for COVID-19. Additionally, we evaluated the quality of the retrieved studies. DATA SOURCES: Clinicaltrials.gov, the Chinese Clinical Trial Registry and the European Union Clinical Trials Register were systematically searched. STUDY ELIGIBILITY CRITERIA: Registered clinical trials examining treatment and/or prevention options for COVID-19 were included. No language, country or study design restrictions were applied. We excluded withdrawn or cancelled studies and trials not reporting therapeutic or preventative strategies for COVID-19. PARTICIPANTS: and interventions: No restrictions in terms of participants’ age and medical background or type of intervention were enforced. METHODS: The registries were searched using the term “coronavirus” or “COVID-19” from their inception until 26(th) March 2020.Additional manual search of the registries was also performed. Eligible studies were summarised and tabulated. Interventional trials were methodologically analysed, excluding expanded access studies and trials testing Traditional Chinese Medicine. RESULTS: In total, 309 trials evaluating therapeutic management options, 23 studies assessing preventive strategies and 3 studies examining both were retrieved. Finally, 214 studies were methodologically reviewed. Interventional treatment studies were mostly randomised (n=150, 76%) and open-label (n=73, 37%) with a median number of planned inclusions of 90 (IQR 40-200). Major categories of interventions that are currently being investigated are discussed. CONCLUSION: Numerous clinical trials have been registered since the onset of the COVID-19 pandemic. Summarised data on these trials will assist physicians and researchers to promote patient care and guide future research efforts for COVID-19 pandemic containment.
has issue date	2020-05-23(xsd:dateTime)
bibo:doi	10.1016/j.cmi.2020.05.019
bibo:pmid	32454187
has license	no-cc
sha1sum (hex)	9c478988e884d1572081be310b4861a2e4a3eda9
schema:url	https://doi.org/10.1016/j.cmi.2020.05.019
resource representing a document's title	Review of trials currently testing treatment and prevention of COVID-19
has PubMed Central identifier	PMC7245266
has PubMed identifier	32454187
schema:publication	Clin Microbiol Infect
resource representing a document's body	covid:9c478988e884d1572081be310b4861a2e4a3eda9#body_text
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