About: Enterovirus D-68 Infection, Prophylaxis, and Vaccination in a Novel Permissive Animal Model, the Cotton Rat (Sigmodon hispidus)

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About: Enterovirus D-68 Infection, Prophylaxis, and Vaccination in a Novel Permissive Animal Model, the Cotton Rat (Sigmodon hispidus) Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Enterovirus D-68 Infection, Prophylaxis, and Vaccination in a Novel Permissive Animal Model, the Cotton Rat (Sigmodon hispidus)
Creator	Wang, Wei Kirkegaard, Karla Tan, Yi Blanco, Jorge Boukhvalova, Marina Das, Suman Hartert, Tina Patel, Mira Pletneva, Lioubov Rajagopala, Seesandra Vogel, Stefanie
Source	Medline; PMC
abstract	In recent years, there has been a significant increase in detection of Enterovirus D-68 (EV-D68) among patients with severe respiratory infections worldwide. EV-D68 is now recognized as a re-emerging pathogen; however, due to lack of a permissive animal model for EV-D68, a comprehensive understanding of the pathogenesis and immune response against EV-D68 has been hampered. Recently, it was shown that EV-D68 has a strong affinity for α2,6-linked sialic acids (SAs) and we have shown previously that α2,6-linked SAs are abundantly present in the respiratory tract of cotton rats (Sigmodon hispidus). Thus, we hypothesized that cotton rats could be a potential model for EV-D68 infection. Here, we evaluated the ability of two recently isolated EV-D68 strains (VANBT/1 and MO/14/49), along with the historical prototype Fermon strain (ATCC), to infect cotton rats. We found that cotton rats are permissive to EV-D68 infection without virus adaptation. The different strains of EV-D68 showed variable infection profiles and the ability to produce neutralizing antibody (NA) upon intranasal infection or intramuscular immunization. Infection with the VANBT/1 resulted in significant induction of pulmonary cytokine gene expression and lung pathology. Intramuscular immunization with live VANBT/1 or MO/14/49 induced strong homologous antibody responses, but a moderate heterologous NA response. We showed that passive prophylactic administration of serum with high content of NA against VANBT/1 resulted in an efficient antiviral therapy. VANBT/1-immunized animals showed complete protection from VANBT/1 challenge, but induced strong pulmonary Th1 and Th2 cytokine responses and enhanced lung pathology, indicating the generation of exacerbated immune response by immunization. In conclusion, our data illustrate that the cotton rat is a powerful animal model that provides an experimental platform to investigate pathogenesis, immune response, anti-viral therapies and vaccines against EV-D68 infection.
has issue date	2016-11-04(xsd:dateTime)
bibo:doi	10.1371/journal.pone.0166336
bibo:pmid	27814404
has license	cc-by
sha1sum (hex)	9c6df064dc7aedea41eca964a69131e37f330f6b
schema:url	https://doi.org/10.1371/journal.pone.0166336
resource representing a document's title	Enterovirus D-68 Infection, Prophylaxis, and Vaccination in a Novel Permissive Animal Model, the Cotton Rat (Sigmodon hispidus)
has PubMed Central identifier	PMC5096705
has PubMed identifier	27814404
schema:publication	PLoS One
resource representing a document's body	covid:9c6df064dc7aedea41eca964a69131e37f330f6b#body_text
is schema:about of	named entity 'PROPHYLAXIS' named entity 'serum' named entity 'cotton' named entity 'cotton' named entity 'EV-D68' named entity 'intramuscular' named entity 'animals' named entity 'neutralizing antibody' named entity 'passive' named entity 'lung' named entity 'Prophylaxis' named entity 'Infection' named entity 'ANIMAL MODEL' named entity 'VIRAL' named entity 'ENTEROVIRUS D' named entity 'CONTENT' named entity 'ANTIVIRAL THERAPY' named entity 'COMPREHENSIVE' named entity 'THERAPIES' named entity 'PASSIVE' named entity 'PROTOTYPE' named entity 'SAS' named entity 'HISTORICAL' named entity 'MODEL' named entity 'TH2 CYTOKINE' named entity 'ANIMALS' named entity 'PULMONARY' named entity 'ENHANCED' named entity 'RECENT' named entity 'RESPONSES' named entity 'INDUCED' named entity 'TO INVESTIGATE' named entity 'TO PRODUCE' named entity 'B12' named entity 'ADMINISTRATION' named entity 'LIVE' named entity 'HAVE' named entity 'PATIENTS' named entity 'CYTOKINE GENE' named entity 'TO INFECT' named entity 'WORLDWIDE' named entity 'PLATFORM' named entity '2F1' named entity 'DUE TO' named entity 'DATA' named entity 'TH1' named entity 'EV-D68' named entity 'RESPIRATORY TRACT' named entity 'EXPERIMENTAL' named entity 'UNDERSTANDING' named entity 'ABILITY' named entity 'STRONG' named entity 'RESPONSE' named entity 'PATHOLOGY' named entity 'STRAIN' named entity 'COTTON RATS' named entity 'VIRUS' named entity 'PATHOGENESIS' named entity 'IMMUNIZED' named entity 'GENE EXPRESSION' covid:arg/9c6df064dc7aedea41eca964a69131e37f330f6b named entity 'INDICATING' named entity 'PROVIDES' named entity 'COMPLETE' named entity 'SERUM' named entity 'MODERATE' named entity 'OUR' named entity 'COTTON RAT' named entity 'VACCINATION' named entity 'NOVEL' named entity 'ISOLATED'

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