About: Beneficial and Detrimental Effects of Regulatory T Cells in Neurotropic Virus Infections

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: Beneficial and Detrimental Effects of Regulatory T Cells in Neurotropic Virus Infections Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Beneficial and Detrimental Effects of Regulatory T Cells in Neurotropic Virus Infections
Creator	Herder, Vanessa Beineke, Andreas Ciurkiewicz, Malgorzata
Source	Medline; PMC
abstract	Neurotropic viruses infect the central nervous system (CNS) and cause acute or chronic neurologic disabilities. Regulatory T cells (Treg) play a critical role for immune homeostasis, but may inhibit pathogen-specific immunity in infectious disorders. The present review summarizes the current knowledge about Treg in human CNS infections and their animal models. Besides dampening pathogen-induced immunopathology, Treg have the ability to facilitate protective responses by supporting effector T cell trafficking to the infection site and the development of resident memory T cells. Moreover, Treg can reduce virus replication by inducing apoptosis of infected macrophages and attenuate neurotoxic astrogliosis and pro-inflammatory microglial responses. By contrast, detrimental effects of Treg are caused by suppression of antiviral immunity, allowing for virus persistence and latency. Opposing disease outcomes following Treg manipulation in different models might be attributed to differences in technique and timing of intervention, infection route, genetic background, and the host’s age. In addition, mouse models of virus-induced demyelination revealed that Treg are able to reduce autoimmunity and immune-mediated CNS damage in a disease phase-dependent manner. Understanding the unique properties of Treg and their complex interplay with effector cells represents a prerequisite for the development of new therapeutic approaches in neurotropic virus infections.
has issue date	2020-03-02(xsd:dateTime)
bibo:doi	10.3390/ijms21051705
bibo:pmid	32131483
has license	cc-by
sha1sum (hex)	9c8c094a83e54d4a3f6fba2fc8a4b95f889c062c
schema:url	https://doi.org/10.3390/ijms21051705
resource representing a document's title	Beneficial and Detrimental Effects of Regulatory T Cells in Neurotropic Virus Infections
has PubMed Central identifier	PMC7084400
has PubMed identifier	32131483
schema:publication	Int J Mol Sci
resource representing a document's body	covid:9c8c094a83e54d4a3f6fba2fc8a4b95f889c062c#body_text
is schema:about of	covid:arg/9c8c094a83e54d4a3f6fba2fc8a4b95f889c062c named entity 'Treg' named entity 'immunopathology' named entity 'unique properties' named entity 'antiviral' named entity 'Treg' named entity 'neurotropic virus' named entity 'Treg' named entity 'effector T cell' named entity 'CNS' named entity 'virus' named entity 'effector cells' named entity 'critical role' named entity 'encephalitis' named entity 'cellular network' named entity 'infection' named entity 'Treg' named entity 'hemorrhage' named entity 'Treg' named entity 'Treg' named entity 'Treg' named entity 'TMEV' named entity 'clinical outcome' named entity 'killer cell' named entity 'immunomodulatory' named entity 'Treg' named entity 'Treg' named entity 'Foxp3' named entity 'hippocampal' named entity 'genetic background' named entity 'CNS' named entity 'memory T cell' named entity 'cytokines' named entity 'animal models' named entity 'Treg' named entity 'CNS' named entity 'Treg' named entity 'IL-10' named entity 'MHV' named entity 'CD4 +' named entity 'immunopathology' named entity 'IFN-γ' named entity 'Treg' named entity 'diphtheria toxin' named entity 'neuroprotective' named entity 'myelin' named entity 'causality' named entity 'genetic background' named entity 'IL-10' named entity 'viral load' named entity 'oligodendrocytes' named entity 'Treg' named entity 'high affinity' named entity 'infection' named entity 'CNS' named entity 'Treg' named entity 'IL-10' named entity 'Treg' named entity 'antibodies' named entity 'TMEV' named entity 'neurologic disease' named entity 'IL-10' named entity 'Treg' named entity 'Acid sphingomyelinase' named entity 'demyelination' named entity 'effector T cell' named entity 'immunomodulatory' named entity 'IL-10' named entity 'demyelination' named entity 'Infection' named entity 'iTreg' named entity 'immunocompromised' named entity 'effector' named entity 'myeloid' named entity 'inclusion bodies' named entity 'IL-10' named entity 'lymphoid tissues' named entity 'Treg' named entity 'Foxp3'

Faceted Search & Find service v1.13.91 as of Mar 24 2020

Alternative Linked Data Documents: Sponger | ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3229 as of Jul 10 2020, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (94 GB total memory)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software