About: Characterization of the diffuse mucosal associated lymphoid tissue of feline small intestine

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: Characterization of the diffuse mucosal associated lymphoid tissue of feline small intestine Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Characterization of the diffuse mucosal associated lymphoid tissue of feline small intestine
Creator	Moore, P Roccabianca, P Woo, J
Source	Elsevier; Medline; PMC
abstract	Characterization of the feline intestinal mucosal associated lymphoid tissue (MALT) will facilitate investigation of intestinal disease in the cat and promote the cat as an animal model for a range of human diseases which involve the intestinal lymphoid tissue. This includes inflammatory bowel disease, viral and non-viral associated intestinal lymphomas and immunodeficiency associated syndromes. Morphologic and phenotypic characterization of the normal small intestinal diffuse MALT in 22 SPF cats was performed using flow cytometry and cytology on isolated intestinal leukocytes from the intra-epithelial and lamina proprial compartments, as well as immunohistology on tissues from the feline duodenum, jejunum and ileum. The intra-epithelial compartment (IEC) was dominated by lymphocytes (>85%) which frequently contained intracytoplasmic granules. The most striking findings in the IEC were the elevated percentages of CD8α+ lymphocytes (40%), presumed to express CD8αα chains, and CD4−/CD8− (double negative) lymphocytes (44%), and the consistent presence of a minor subpopulation of CD3+/CD11d+ IELs (6%). Small percentages of CD4+ lymphocytes (10%) were observed such that the IEL CD4:CD8 ratio (0.25) was low. The LPC also contained a majority of T cells and few plasma cells. However, this compartment had reduced percentages of CD8α+ lymphocytes (28%) and increased percentages of CD4+ lymphocytes (27%) relative to the IEC. However, the LPL CD4:CD8 ratio (1.0) remained low compared with the ratio in peripheral blood. In feline MALT, MHC class II expression was lower than in other peripheral lymphoid compartments. The results of this study provide important reference values for future investigations involving feline intestinal lymphocytes and demonstrates that the leukocyte distribution and phenotypic characteristics of the feline diffuse MALT appear largely similar to the murine, rat and human counterparts.
has issue date	2000-06-30(xsd:dateTime)
bibo:doi	10.1016/s0165-2427(00)00181-1
bibo:pmid	10889297
has license	no-cc
sha1sum (hex)	9c9b248cf40790e2b897d1fd7f987fdb23bd7cf2
schema:url	https://doi.org/10.1016/s0165-2427%2800%2900181-1
resource representing a document's title	Characterization of the diffuse mucosal associated lymphoid tissue of feline small intestine
has PubMed Central identifier	PMC7119714
has PubMed identifier	10889297
schema:publication	Vet Immunol Immunopathol
resource representing a document's body	covid:9c9b248cf40790e2b897d1fd7f987fdb23bd7cf2#body_text
is schema:about of	named entity 'intestinal' named entity 'range' named entity 'ratio' named entity 'Small' named entity 'intestinal' covid:arg/9c9b248cf40790e2b897d1fd7f987fdb23bd7cf2 named entity 'lymphoid tissue' named entity 'compared' named entity 'CD8' named entity 'double negative' named entity 'lymphocytes' named entity 'human' named entity 'intestinal' named entity 'dominated' named entity 'striking' named entity 'cytology' named entity 'isolated' named entity 'phenotypic' named entity 'syndromes' named entity 'ratio' named entity 'lymphoid tissue' named entity 'intracytoplasmic' named entity 'small intestinal' named entity 'lymphocytes' named entity 'MHC class II' named entity 'MALT' named entity 'CD3' named entity 'CD4' named entity 'mucosal' named entity 'cytology' named entity 'CD8' named entity 'plasma cells' named entity 'jejunum' named entity 'MALT' named entity 'leukocyte' named entity 'phenotypic' named entity 'feline' named entity 'CD4' named entity 'CD3e' named entity 'IEL' named entity 'CD8' named entity 'phenotypic' named entity 'IEC' named entity 'myeloma' named entity 'proteolytic activity' named entity 'IELs' named entity 'tissue distribution' named entity 'CD3e' named entity 'CD8' named entity 'Phenotypically' named entity 'IEC' named entity 'CD8 T cells' named entity 'CD3e' named entity 'IELs' named entity 'CD11a' named entity 'epithelial cells' named entity 'Tissue sections' named entity 'type III' named entity 'lymphocyte' named entity 'macrophages' named entity 'acetone' named entity 'lymphocytes' named entity 'CD8b' named entity 'Gaithersburg' named entity 'Quest software' named entity 'MALT' named entity 'amino acid sequence' named entity 'lymphocytes' named entity 'TCR' named entity 'integrin' named entity 'lymphocytes' named entity 'IELs' named entity 'primary antibody' named entity 'anatomical location' named entity 'intracytoplasmic' named entity 'Phenotypic' named entity 'Antigen' named entity 'CD4' named entity 'CD8'

Faceted Search & Find service v1.13.91 as of Mar 24 2020

Alternative Linked Data Documents: Sponger | ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3229 as of Jul 10 2020, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (94 GB total memory)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software