About: CD200 Receptor Restriction of Myeloid Cell Responses Antagonizes Antiviral Immunity and Facilitates Cytomegalovirus Persistence within Mucosal Tissue

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: CD200 Receptor Restriction of Myeloid Cell Responses Antagonizes Antiviral Immunity and Facilitates Cytomegalovirus Persistence within Mucosal Tissue Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	CD200 Receptor Restriction of Myeloid Cell Responses Antagonizes Antiviral Immunity and Facilitates Cytomegalovirus Persistence within Mucosal Tissue
Creator	Hussell, Tracy Snelgrove, Robert Ghazal, Peter Jones, Emma Lacaze, Paul Marsden, Morgan Stack, Gabrielle Cuff, Simone Gallimore, Awen Humphreys, Ian Stacey, Maria Stanton, Richard Taylor, Philip Wilkinson, Gavin
topic	covid:9d089a2632f7a6fc75d5e723ebe2ac9db15c0048#this
Source	Medline; PMC
abstract	CD200 receptor (CD200R) negatively regulates peripheral and mucosal innate immune responses. Viruses, including herpesviruses, have acquired functional CD200 orthologs, implying that viral exploitation of this pathway is evolutionary advantageous. However, the role that CD200R signaling plays during herpesvirus infection in vivo requires clarification. Utilizing the murine cytomegalovirus (MCMV) model, we demonstrate that CD200R facilitates virus persistence within mucosal tissue. Specifically, MCMV infection of CD200R-deficient mice (CD200R(-/-)) elicited heightened mucosal virus-specific CD4 T cell responses that restricted virus persistence in the salivary glands. CD200R did not directly inhibit lymphocyte effector function. Instead, CD200R(-/-) mice exhibited enhanced APC accumulation that in the mucosa was a consequence of elevated cellular proliferation. Although MCMV does not encode an obvious CD200 homolog, productive replication in macrophages induced expression of cellular CD200. CD200 from hematopoietic and non-hematopoietic cells contributed independently to suppression of antiviral control in vivo. These results highlight the CD200-CD200R pathway as an important regulator of antiviral immunity during cytomegalovirus infection that is exploited by MCMV to establish chronicity within mucosal tissue.
has issue date	2015-02-05(xsd:dateTime)
bibo:doi	10.1371/journal.ppat.1004641
bibo:pmid	25654642
has license	cc-by
sha1sum (hex)	9d089a2632f7a6fc75d5e723ebe2ac9db15c0048
schema:url	https://doi.org/10.1371/journal.ppat.1004641
resource representing a document's title	CD200 Receptor Restriction of Myeloid Cell Responses Antagonizes Antiviral Immunity and Facilitates Cytomegalovirus Persistence within Mucosal Tissue
has PubMed Central identifier	PMC4412112
has PubMed identifier	25654642
schema:publication	PLoS Pathog
resource representing a document's body	covid:9d089a2632f7a6fc75d5e723ebe2ac9db15c0048#body_text
is http://vocab.deri.ie/void#inDataset of	proxy:http/ns.inria.fr/covid19/9d089a2632f7a6fc75d5e723ebe2ac9db15c0048
is schema:about of	named entity 'PERIPHERAL' named entity 'INCLUDING' named entity 'HERPESVIRUS INFECTION' named entity 'MUCOSAL' named entity 'PATHWAY' named entity 'ACQUIRED' named entity 'VIRUSES' named entity 'CD200' named entity 'VIRUS PERSISTENCE' named entity 'orthologs' named entity 'MCMV' named entity 'Cytomegalovirus' named entity 'Immunity' named entity 'MUCOSAL TISSUE' named entity 'PLAYS' named entity 'CLARIFICATION' named entity 'RECEPTOR' named entity 'CD200R' named entity 'ROLE' named entity 'HAVE' named entity 'HERPESVIRUSES' named entity 'MODEL' named entity 'ANTIVIRAL' named entity 'RECEPTOR' named entity 'MYELOID CELL' named entity 'RESPONSES' named entity 'CYTOMEGALOVIRUS' named entity 'RESTRICTION' named entity 'CD200' named entity 'SIGNALING' named entity 'FUNCTIONAL' named entity 'VIRAL' named entity 'IN VIVO' named entity 'MURINE CYTOMEGALOVIRUS' named entity 'PERSISTENCE' named entity 'IMMUNITY' named entity 'IMMUNE RESPONSES' named entity 'peripheral' named entity 'murine' named entity 'receptor' named entity 'mucosal' named entity 'Viruses' named entity 'CD200R' named entity 'infection' named entity 'cytomegalovirus' named entity 'herpesviruses' named entity 'herpesvirus' named entity 'Antagonizes' named entity 'CD200' named entity 'Receptor' named entity 'Cytomegalovirus' named entity 'salivary glands' named entity 'host immunity' named entity 'leukocytes' named entity 'infection' named entity 'APCs' named entity 'endothelial cells' named entity 'CD8 T cell' named entity 'macrophages' named entity 'CD200' named entity 'negatively regulates' named entity 'CD200R' named entity 'CD200R' named entity 'infection' named entity 'organ' named entity 'protein'

Faceted Search & Find service v1.13.91 as of Mar 24 2020

Alternative Linked Data Documents: Sponger | ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3229 as of Jul 10 2020, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (94 GB total memory)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software