About: Down Syndrome Reduces the Sedative Effect of Midazolam in Pediatric Cardiovascular Surgical Patients

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About: Down Syndrome Reduces the Sedative Effect of Midazolam in Pediatric Cardiovascular Surgical Patients Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Down Syndrome Reduces the Sedative Effect of Midazolam in Pediatric Cardiovascular Surgical Patients
Creator	Enomoto, Yuki Hiramatsu, Yuji Hoshino, Haruhiko Inoue, Yoshiaki Mathis, Bryan Matsuishi, Yujiro Sakuramoto, Hideaki
Source	PMC
abstract	Down syndrome (DS) is frequently comorbid with congenital heart disease and has recently been shown to reduce the sedative effect of benzodiazepine (BDZ)-class anesthesia but this effect in a clinical setting has not been studied. Therefore, this study compared midazolam sedation after heart surgery in DS and normal children. We retrospectively reviewed patient records in our pediatric intensive care unit (PICU) of pediatric cardiovascular operations between March 2015 and March 2018. We selected five days of continuous post-operative data just after termination of muscle relaxants. Midazolam sedation was estimated by Bayesian inference for generalized linear mixed models. We enrolled 104 patients (average age 26 weeks) of which 16 (15%) had DS. DS patients had a high probability of receiving a higher midazolam dosage and dexmedetomidine dosage over the study period (probability = 0.99, probability = 0.97) while depth of sedation was not different in DS patients (probability = 0.35). Multi regression modeling included severity scores and demographic data showed DS decreases midazolam sedation compared with controls (posterior OR = 1.32, 95% CrI = 1.01–1.75). In conclusion, midazolam dosages should be carefully adjusted as DS significantly decreases midazolam sedative effect in pediatric heart surgery patients.
has issue date	2020-02-10(xsd:dateTime)
bibo:doi	10.1038/s41598-020-58283-1
bibo:pmid	32041972
has license	cc-by
sha1sum (hex)	9d40970b4d3287ad3b0f5292d7bdea723a573354
schema:url	https://doi.org/10.1038/s41598-020-58283-1
resource representing a document's title	Down Syndrome Reduces the Sedative Effect of Midazolam in Pediatric Cardiovascular Surgical Patients
has PubMed Central identifier	PMC7010829
has PubMed identifier	32041972
schema:publication	Sci Rep
resource representing a document's body	covid:9d40970b4d3287ad3b0f5292d7bdea723a573354#body_text
is schema:about of	named entity 'midazolam' named entity 'comorbid' named entity 'compared' named entity 'age' named entity 'Multi' named entity 'selected' named entity 'Sedative' named entity 'MULTI' named entity 'PROBABILITY OF' named entity 'DAYS' named entity 'SCORES' named entity 'HIGHER' named entity 'DIFFERENT' named entity '1.75' named entity '104' named entity 'PEDIATRIC INTENSIVE CARE UNIT' named entity 'MARCH' named entity 'SELECTED' named entity 'CONGENITAL HEART DISEASE' named entity 'DOSAGES' named entity 'benzodiazepine' named entity 'dexmedetomidine' named entity 'sedation' named entity 'March' named entity 'Bayesian inference' named entity 'higher' named entity 'dosages' named entity 'midazolam' named entity 'heart surgery' named entity 'posterior' named entity 'average' named entity '2018' named entity 'termination' named entity 'Midazolam' named entity 'probability' named entity 'PICU' named entity 'anesthesia' named entity 'sedation' named entity 'sedative' named entity 'congenital heart disease' named entity 'midazolam' named entity 'cardiovascular operations' named entity 'probability' named entity 'muscle relaxants' named entity 'Cardiovascular' named entity 'Sedative' named entity 'Midazolam' named entity 'withdrawal symptoms' named entity 'surgical procedures' named entity 'clinical care' named entity 'sedative' named entity 'delirium' named entity 'Statistical analysis' named entity 'clinical studies' named entity 'BDZ' named entity 'prior distribution' named entity 'Ethics' named entity 'muscle relaxant' named entity 'organ' named entity 'clinical evidence' named entity 'credible interval' named entity 'PICU' named entity 'mortality risk' named entity 'organ dysfunction' named entity 'standard deviation' named entity 'anesthesia' named entity 'Markov chain Monte Carlo' named entity 'Bayesian inference' named entity 'hemodynamic' named entity 'Standard Error' named entity '3.5' named entity 'effective sample size' named entity 'MCSE' named entity 'SBS' named entity 'muscle relaxant'

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