About: An APN-activated NIR photosensitizer for cancer photodynamic therapy and fluorescence imaging

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About: An APN-activated NIR photosensitizer for cancer photodynamic therapy and fluorescence imaging Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	An APN-activated NIR photosensitizer for cancer photodynamic therapy and fluorescence imaging
Creator	Xu, Feng Zhang, Zhen Shi, Chao Li, Zhou Sun, Wen Du, Jianjun Fan, Jiangli Li, Haidong Long, Saran Ma, He Peng, Xiaojun Shao, Kun Wang, Jingyun Yao, Qichao Zhou, Xiao
Source	Elsevier; Medline; PMC
abstract	Abstract Photodynamic therapy has been developed as a prospective cancer treatment in recent years. Nevertheless, conventional photosensitizers suffer from lacking recognition and specificity to tumors, which causing severe side effects to normal tissues, while the enzyme-activated photosensitizers are capable of solving these conundrums due to high selectivity towards tumors. APN (Aminopeptidase N, APN/CD13), a tumor marker, has become a crucial targeting substance owing to its highly expressed on the cell membrane surface in various tumors, which has become a key point in the research of anti-tumor drug and fluorescence probe. Based on it, herein an APN-activated near-infrared (NIR) photosensitizer (APN-CyI) for tumor imaging and photodynamic therapy has been firstly developed and successfully applied in vitro and in vivo. Studies showed that APN-CyI could be activated by APN in tumor cells, hydrolyzed to fluorescent CyI-OH, which specifically located in mitochondria in cancer cells and exhibited a high singlet oxygen yield under NIR irradiation, and efficiently induced cancer cell apoptosis. Dramatically, the in vivo assays on Balb/c mice showed that APN-CyI could achieve NIR fluorescence imaging (λem = 717 nm) for endogenous APN in tumors and possessed an efficient tumor suppression effect under NIR irradiation.
has issue date	2020-05-03(xsd:dateTime)
bibo:doi	10.1016/j.biomaterials.2020.120089
bibo:pmid	32447103
has license	els-covid
sha1sum (hex)	9d7ebfb48928ae82891a82ccc60ddb90b85b4bb9
schema:url	https://doi.org/10.1016/j.biomaterials.2020.120089
resource representing a document's title	An APN-activated NIR photosensitizer for cancer photodynamic therapy and fluorescence imaging
has PubMed Central identifier	PMC7196320
has PubMed identifier	32447103
schema:publication	Biomaterials
resource representing a document's body	covid:9d7ebfb48928ae82891a82ccc60ddb90b85b4bb9#body_text
is schema:about of	named entity 'severe' named entity 'tissues' named entity 'mitochondria' named entity 'apoptosis' named entity 'cancer' named entity 'LACKING' named entity 'SIDE EFFECTS' named entity 'PROSPECTIVE' named entity 'CYI' named entity 'MEMBRANE SURFACE' named entity 'CAUSING' named entity 'singlet oxygen' named entity 'cancer' named entity 'substance' named entity 'tumors' named entity 'tumor marker' named entity 'imaging' named entity 'point' named entity 'hydrolyzed' named entity 'APN' named entity 'author' named entity 'photosensitizers' named entity 'singlet oxygen' named entity 'tumors' named entity 'near-infrared' named entity 'fluorescence imaging' named entity 'enzyme' named entity 'fluorescence' named entity 'irradiation' named entity 'tumor marker' named entity 'Aminopeptidase' named entity 'photosensitizer' named entity 'NIR' named entity 'tumors' named entity 'photodynamic therapy' named entity 'NMR spectra' named entity 'DMEM' named entity 'column chromatography' named entity 'cancer therapeutics' named entity 'hydrolyzed' named entity 'solvent' named entity 'metastasis' named entity 'photodynamic therapy' named entity 'SPF' named entity 'Charge Transfer' named entity 'objective lens' named entity 'Balb/c' named entity 'Calcein' named entity 'microplate reader' named entity 'photosensitizer' named entity 'GGT' named entity 'fluorophore' named entity 'EPR' named entity 'silica gel' named entity '4T1' named entity 'fluorescence' named entity 'singlet oxygen' named entity '2-hydroxy-4-methoxybenzaldehyde' named entity 'Mass spectra' named entity 'NaCl' named entity 'biochemical' named entity 'N-acetyl-L-cysteine' named entity 'indole' named entity 'reactive oxygen species' named entity 'DMSO' named entity 'photodynamic therapy' named entity 'solvent'

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