About: Early immune responses and development of pathogenesis of avian infectious bronchitis viruses with different virulence profiles

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About: Early immune responses and development of pathogenesis of avian infectious bronchitis viruses with different virulence profiles Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Early immune responses and development of pathogenesis of avian infectious bronchitis viruses with different virulence profiles
Creator	Brentano, Liana Coldebella, Arlei Montassier, Hélio Antô, Marcos Hiromi, Cintia Mores, Zanella Trevisol, Iara
Source	Medline; PMC
abstract	Avian infectious bronchitis virus (IBV) primarily replicates in epithelial cells of the upper respiratory tract of chickens, inducing both morphological and immune modulatory changes. However, the association between the local immune responses induced by IBV and the mechanisms of pathogenesis has not yet been completely elucidated. This study compared the expression profile of genes related to immune responses in tracheal samples after challenge with two Brazilian field isolates (A and B) of IBV from the same genotype, associating these responses with viral replication and with pathological changes in trachea and kidney. We detected a suppressive effect on the early activation of TLR7 pathway, followed by lower expression levels of inflammatory related genes induced by challenge with the IBV B isolate when compared to the challenge with to the IBV A isolate. Cell-mediated immune (CMI) related genes presented also lower levels of expression in tracheal samples from birds challenged with B isolate at 1dpi. Increased viral load and a higher percentage of birds with relevant lesions were observed in both tracheal and renal samples from chickens exposed to challenge with IBV B isolate. This differential pattern of early immune responses developed after challenge with IBV B isolate, related to the downregulation of TLR7, leading to insufficient pro-inflammatory response and lower CMI responses, seem to have an association with a most severe renal lesion and an enhanced capability of replication of this isolate in chicken.
has issue date	2017-02-15(xsd:dateTime)
bibo:doi	10.1371/journal.pone.0172275
bibo:pmid	28199419
has license	cc-by
sha1sum (hex)	9d8670d2d8e18f181af7f6fc61db4424026f384e
schema:url	https://doi.org/10.1371/journal.pone.0172275
resource representing a document's title	Early immune responses and development of pathogenesis of avian infectious bronchitis viruses with different virulence profiles
has PubMed Central identifier	PMC5310907
has PubMed identifier	28199419
schema:publication	PLoS One
resource representing a document's body	covid:9d8670d2d8e18f181af7f6fc61db4424026f384e#body_text
is schema:about of	named entity 'AVIAN INFECTIOUS BRONCHITIS' named entity 'renal' named entity 'lesion' named entity 'immune responses' named entity 'DEVELOPMENT' named entity 'RELATED' named entity 'STUDY' named entity 'ACTIVATION' named entity 'PATHOGENESIS' named entity 'COMPARED' named entity 'INDUCING' named entity 'VIRUSES' named entity 'DETECTED' named entity 'LESION' named entity 'EARLY' named entity 'ASSOCIATING' named entity 'ISOLATES' named entity 'ASSOCIATION' named entity 'CELL' named entity 'ISOLATE' covid:arg/9d8670d2d8e18f181af7f6fc61db4424026f384e named entity 'DOWNREGULATION' named entity 'PRESENTED' named entity 'PATHOLOGICAL' named entity 'CAPABILITY' named entity 'MORPHOLOGICAL' named entity 'AVIAN INFECTIOUS BRONCHITIS VIRUS' named entity 'TRACHEA' named entity 'DIFFERENT' named entity 'PATTERN' named entity 'SAMPLES' named entity 'CHANGES' named entity 'OBSERVED' named entity 'PATHOGENESIS' named entity 'VIRULENCE' named entity 'IMMUNE RESPONSES' named entity 'EARLY' named entity 'FIELD' named entity 'PRO-INFLAMMATORY RESPONSE' named entity 'BIRDS' named entity 'SUPPRESSIVE EFFECT' named entity 'LOWER' named entity 'TLR7' named entity 'VIRAL REPLICATION' named entity 'GENOTYPE' named entity 'DIFFERENTIAL' named entity 'IMMUNE' named entity 'CHALLENGE' named entity 'SEVERE' named entity 'LOCAL' named entity 'PERCENTAGE' named entity 'LEVELS' named entity 'KIDNEY' named entity 'GENES' named entity 'RESPONSES' named entity 'CHICKEN' named entity 'PATHWAY' named entity 'REPLICATION' named entity 'IMMUNE RESPONSES' named entity 'MEDIATED' named entity 'VIRAL LOAD' named entity 'EPITHELIAL CELLS' named entity 'TRACHEAL' named entity 'EXPRESSION' named entity 'RENAL' named entity 'UPPER RESPIRATORY TRACT' named entity 'EXPRESSION PROFILE' named entity 'EXPOSED TO' named entity 'MECHANISMS' named entity 'ENHANCED' named entity 'THESE' named entity 'HAVE' named entity 'HIGHER' named entity 'INCREASED' named entity 'FOLLOWED BY'

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