About: A second, non-canonical RNA-dependent RNA polymerase in SARS Coronavirus

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	A second, non-canonical RNA-dependent RNA polymerase in SARS Coronavirus
Creator	Canard, Bruno Coutard, Bruno Imbert, Isabelle Guillemot, Jean-Claude Egloff, Marie-Pierre Gorbalenya, Alexander Bourhis, Jean-Marie Ois Ferron, Franç Cile Bussetta, Cé
topic	covid:9d9e41392d9817eeb79b994908433088e3aabff6#this
Source	Medline; PMC
abstract	In (+) RNA coronaviruses, replication and transcription of the giant ∼30 kb genome to produce genome- and subgenome-size RNAs of both polarities are mediated by a cognate membrane-bound enzymatic complex. Its RNA-dependent RNA polymerase (RdRp) activity appears to be supplied by non-structural protein 12 (nsp12) that includes an RdRp domain conserved in all RNA viruses. Using SARS coronavirus, we now show that coronaviruses uniquely encode a second RdRp residing in nsp8. This protein strongly prefers the internal 5′-(G/U)CC-3′ trinucleotides on RNA templates to initiate the synthesis of complementary oligonucleotides of <6 residues in a reaction whose fidelity is relatively low. Distant structural homology between the C-terminal domain of nsp8 and the catalytic palm subdomain of RdRps of RNA viruses suggests a common origin of the two coronavirus RdRps, which however may have evolved different sets of catalytic residues. A parallel between the nsp8 RdRp and cellular DNA-dependent RNA primases is drawn to propose that the nsp8 RdRp produces primers utilized by the primer-dependent nsp12 RdRp.
has issue date	2006-10-05(xsd:dateTime)
bibo:doi	10.1038/sj.emboj.7601368
bibo:pmid	17024178
has license	green-oa
sha1sum (hex)	9d9e41392d9817eeb79b994908433088e3aabff6
schema:url	https://doi.org/10.1038/sj.emboj.7601368
resource representing a document's title	A second, non-canonical RNA-dependent RNA polymerase in SARS Coronavirus
has PubMed Central identifier	PMC1618104
has PubMed identifier	17024178
schema:publication	The EMBO Journal
resource representing a document's body	covid:9d9e41392d9817eeb79b994908433088e3aabff6#body_text
is http://vocab.deri.ie/void#inDataset of	proxy:http/ns.inria.fr/covid19/9d9e41392d9817eeb79b994908433088e3aabff6
is schema:about of	named entity 'evolved' named entity 'reaction' named entity 'polymerase' named entity 'SARS CORONAVIRUS' named entity 'ENCODE' named entity 'INITIATE' named entity 'CATALYTIC' named entity 'SARS CORONAVIRUS' named entity 'CONSERVED' named entity 'RNA' named entity 'MEDIATED' named entity 'CORONAVIRUS' named entity 'STRUCTURAL HOMOLOGY' named entity 'COMPLEX' named entity 'DNA' named entity 'CORONAVIRUSES' named entity 'FIDELITY' named entity 'RNA-DEPENDENT RNA POLYMERASE' named entity 'REACTION' named entity 'DOMAIN' named entity 'NON-' named entity 'ACTIVITY' named entity 'TRANSCRIPTION' named entity 'SIZE' named entity 'OLIGONUCLEOTIDES' named entity 'SECOND' named entity 'GIANT' named entity 'USING' named entity 'RNA VIRUSES' named entity 'MEMBRANE' named entity 'INTERNAL' named entity 'REPLICATION' named entity 'CELLULAR' named entity 'A COMMON' named entity 'SUBDOMAIN' named entity 'GENOME' named entity 'NON-' named entity 'RDRP' named entity 'STRUCTURAL PROTEIN' named entity 'COMMON ORIGIN' named entity 'B30' named entity 'SUPPLIED' named entity 'EVOLVED' named entity 'LOW' named entity 'DEPENDENT' named entity 'DISTANT' named entity 'MAY HAVE' named entity 'DIFFERENT' named entity 'PROTEIN ' named entity 'PALM' named entity 'INCLUDES' named entity 'PARALLEL' named entity 'SYNTHESIS' named entity 'RNA POLYMERASE' named entity 'ENZYMATIC' named entity 'TO PRODUCE' named entity 'PRIMERS' named entity 'ITS' named entity '28G' named entity 'TEMPLATES' named entity 'BOUND' named entity 'C-TERMINAL' named entity 'SECOND' covid:arg/9d9e41392d9817eeb79b994908433088e3aabff6 named entity 'RdRp' named entity 'RNA' named entity 'cellular' named entity 'SARS coronavirus' named entity 'oligonucleotides' named entity 'residues' named entity 'B30'

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