About: Pathogenicity, tissue tropism and potential vertical transmission of SARSr-CoV-2 in Malayan pangolins

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About: Pathogenicity, tissue tropism and potential vertical transmission of SARSr-CoV-2 in Malayan pangolins Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Pathogenicity, tissue tropism and potential vertical transmission of SARSr-CoV-2 in Malayan pangolins
Creator	Xiao, Lihua Wang, Chen Shen, Xuejuan Shen, Yongyi Chen, Wu Zhang, Xu Li, Xiaobing He, Qian Feng, Yaoyu Holmes, Edward Wang, Ruichen Xiao, Kangpeng Zhang, Zhipeng Chen, Rui-Ai Chen, Xiaoyuan Irwin, David Chen, Zu-Jin Com, Guangzhouchenwu@sina Dai, Jun-Wei Du, Xue-Qing Li, Wan-Ping Liang, Xianghui Peng, Shi-Ming Shan, Fen Su, Renwei Wu, Ya-Jiang Xie, Wei-Jun Zhai, Junqiong Zhou, Fuqing Zhou, Niu
Source	BioRxiv
abstract	SARS-CoV-2 is having severe impact on public health at a global scale. Malayan pangolin SARS-CoV-2-related coronavirus (SARSr-CoV-2) is closely related to SARS-CoV-2. We show that CT scans of virus-positive pangolins reveal bilateral ground-glass opacities in lungs in similar manner to COVID-19 patients. The virus infected multiple organs in pangolins, with the lungs being the major target. Histological expression showed that ACE2 and TMPRSS2 are co-expressed with viral RNA. Transcriptome analysis revealed an inadequate interferon response, with different dysregulated chemokines and cytokines responses in pregnant and non-pregnant adults and fetuses. Viral RNA and protein were detected in three fetuses providing evidence for vertical virus transmission. In sum, our study identifies the biological framework of SARSr-CoV-2 in pangolins, revealing striking similarities to COVID-19 in humans.
has issue date	2020-06-22(xsd:dateTime)
bibo:doi	10.1101/2020.06.22.164442
has license	biorxiv
sha1sum (hex)	9db801028ebecca7028844ca0ff596fb4f19e122
schema:url	https://doi.org/10.1101/2020.06.22.164442
resource representing a document's title	Pathogenicity, tissue tropism and potential vertical transmission of SARSr-CoV-2 in Malayan pangolins
schema:publication	bioRxiv
resource representing a document's body	covid:9db801028ebecca7028844ca0ff596fb4f19e122#body_text
is schema:about of	named entity 'SARS-CoV-2' named entity 'MULTIPLE' named entity 'BEING' named entity 'ORGANS' named entity 'SARS-COV-2' named entity 'scale' named entity 'COVID-19' named entity 'ground-glass opacities' named entity 'public health' named entity 'CT scans' named entity 'pangolins' named entity 'SARSr-CoV' named entity 'pangolins' named entity 'public health' named entity 'similar manner' named entity 'vertical transmission' named entity 'vertical transmission' named entity 'spike protein' named entity 'intestine' named entity 'multiple organ dysfunction syndrome' named entity 'pangolin' named entity 'respiratory symptoms' named entity 'ACE2' named entity 'SARS-CoV-2' named entity 'respiratory symptoms' named entity 'intestine' named entity 'organ' named entity 'pathogenicity' named entity 'SARS-CoV-2' named entity 'pregnancy' named entity 'TMPRSS2' named entity 'ACE2 receptor' named entity 'COVID' named entity 'pangolins' named entity 'formalin' named entity 'coronavirus disease' named entity 'transgenic mouse' named entity 'coronaviruses' named entity 'distilled water' named entity 'mmol' named entity 'spike protein' named entity 'SARS-CoV-2' named entity 'SARSr-CoV' named entity 'macrophages' named entity 'pangolins' named entity 'SARSr-CoV' named entity 'epithelia' named entity 'COVID' named entity 'genome' named entity 'pangolin' named entity 'pathogenicity' named entity 'SARS-CoV-2' named entity 'SARSr-CoV' named entity 'viral infection' named entity 'macaques'

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