About: Molecular Characterization of Major Structural Protein Genes of Avian Coronavirus Infectious Bronchitis Virus Isolates in Southern China

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About: Molecular Characterization of Major Structural Protein Genes of Avian Coronavirus Infectious Bronchitis Virus Isolates in Southern China Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Molecular Characterization of Major Structural Protein Genes of Avian Coronavirus Infectious Bronchitis Virus Isolates in Southern China
Creator	Mo, Mei-Lan Wei, Ping Li, Meng Cheng, Qiu-Ying Fan, Wen-Sheng Huang, Bai-Cheng Lang, Ya-Hui Wei, Tian-Chao Wei, Zheng-Ji
Source	Medline; PMC
abstract	To gain comprehensive genetic information of circulating avian coronavirus infectious bronchitis virus (IBV) isolates in China, analysis of the phylogenetic tree, entropy of the amino acid sequences, and the positive selection as well as computational recombinations of S1, M and N genes of 23 IBV isolates was conducted in the present study. The phylogenetic trees based on the S1, M and N genes exhibited considerably different topology and the CK/CH/LSC/99I-type isolates were the predominant IBVs based on the phylogenetic analysis of S1 gene. Results of entropy of amino acid sequences revealed that the S1 gene had the largest variation; the M gene had less variation than the N gene. Positive selections were detected in not only S1 but also M and N gene proteins. In addition, five S1 gene recombinants between vaccine strain 4/91 and CK/CH/LSC/99I-type field isolate were confirmed. In conclusion, multiple IBV genotypes co-circulated; genetic diversity and positive selections existed in S1, M and N genes; 4/91 vaccine recombinants emerged in China. Our results show that field IBVs in China are continuing to evolve and vaccine strains may have an important role in the appearance of new IBV strains via recombination. In addition, the present study indicates that IBV evolution is driven by both generations of genetic diversity and selection.
has issue date	2013-12-04(xsd:dateTime)
bibo:doi	10.3390/v5123007
bibo:pmid	24304696
has license	cc-by
sha1sum (hex)	9dbde5d85011e2cb16e7d996421db75323ea21c0
schema:url	https://doi.org/10.3390/v5123007
resource representing a document's title	Molecular Characterization of Major Structural Protein Genes of Avian Coronavirus Infectious Bronchitis Virus Isolates in Southern China
has PubMed Central identifier	PMC3967158
has PubMed identifier	24304696
schema:publication	Viruses
resource representing a document's body	covid:9dbde5d85011e2cb16e7d996421db75323ea21c0#body_text
is schema:about of	named entity 'OUR' named entity 'VACCINE' named entity 'CIRCULATING' named entity 'VACCINE STRAIN' named entity 'ADDITION' named entity 'TOPOLOGY' named entity 'ENTROPY' named entity 'PHYLOGENETIC TREE' named entity 'PHYLOGENETIC ANALYSIS' named entity 'RECOMBINATIONS' named entity 'GAIN' named entity 'TREES' named entity 'DIFFERENT' named entity 'CONCLUSION' named entity 'N GENE' named entity 'amino acid' named entity 'computational' named entity 'gene' named entity 'China' named entity 'sequences' named entity 'Structural' named entity 'Characterization' named entity 'Molecular' named entity 'CHARACTERIZATION' named entity 'GENES' named entity 'CHINA' named entity 'MAJOR' named entity 'EVOLVE' named entity 'FIELD' named entity 'ISOLATES' named entity 'M GENE' named entity 'ISOLATE' named entity 'RECOMBINANTS' named entity 'VARIATION' named entity 'POSITIVE SELECTION' named entity 'S1 GENE' named entity 'GENETIC INFORMATION' named entity 'ISOLATES' named entity 'PROTEIN ' named entity 'AVIAN CORONAVIRUS' named entity 'STRUCTURAL PROTEIN' named entity 'MOLECULAR' named entity 'AMINO ACID SEQUENCES' named entity 'GENETIC DIVERSITY' named entity 'BUT' named entity 'CHINA' named entity 'CONFIRMED' named entity 'PROTEINS' named entity 'DETECTED' named entity 'RESULTS' named entity 'PRESENT' named entity 'CONTINUING' named entity 'INFECTIOUS BRONCHITIS VIRUS' named entity 'SOUTHERN' named entity 'INFECTIOUS BRONCHITIS VIRUS' named entity 'AVIAN CORONAVIRUS' named entity 'GENES' named entity 'ANALYSIS' named entity 'GENOTYPES' named entity 'LARGEST' named entity 'POSITIVE' named entity 'COMPUTATIONAL' named entity 'REVEALED' named entity 'STUDY' named entity 'MULTIPLE' named entity 'BASED' named entity 'TYPE' named entity 'PREDOMINANT' named entity 'COMPREHENSIVE' covid:arg/9dbde5d85011e2cb16e7d996421db75323ea21c0 named entity 'infectious bronchitis' named entity 'isolates' named entity 'emerged'

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