About: Putative roles of the CNF2 and CDTIII toxins in experimental infections with necrotoxigenic Escherichia coli type 2 (NTEC2) strains in calves

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About: Putative roles of the CNF2 and CDTIII toxins in experimental infections with necrotoxigenic Escherichia coli type 2 (NTEC2) strains in calves Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Putative roles of the CNF2 and CDTIII toxins in experimental infections with necrotoxigenic Escherichia coli type 2 (NTEC2) strains in calves
Creator	Mainil, Jacques Roels, Stefan Van Bost, Sigrid Oswald, Eric
Source	Elsevier; Medline; PMC
abstract	Abstract Newborn colostrum-restricted calves were orally inoculated with an Escherichia coli strain, identified originally as non-pathogenic, and into which the plasmid pVir was conjugally transferred. This resulted in diarrhea, intestinal lesions and extra-intestinal invasion, suggesting that factors affecting these pathogenic properties are located on pVir. In order to analyze the respective roles of the toxins CNF2 and CDTIII in the pathogenesis, colostrum-restricted calves were inoculated with isogenic mutants in the cnf2 and the cdt-III genes. The loss of cnf2 is associated with a reduction in the pathogenicity, since diarrhea does not occur in calves challenged, in spite of successful colonization of the intestine. Nevertheless, the mutant strain remains able to invade the bloodstream and to localize in the internal organs. Conversely, the calves inoculated with mutant in the cdt-III gene evolved in the same way as wild-type strain-inoculated calves with regard to clinical signs and macroscopic or microscopic lesions.
has issue date	2003-11-30(xsd:dateTime)
bibo:doi	10.1016/j.micinf.2003.08.005
bibo:pmid	14623014
has license	els-covid
sha1sum (hex)	9dfe72a2237c75f92ed14d15dcd22d3f4505edf8
schema:url	https://doi.org/10.1016/j.micinf.2003.08.005
resource representing a document's title	Putative roles of the CNF2 and CDTIII toxins in experimental infections with necrotoxigenic Escherichia coli type 2 (NTEC2) strains in calves
has PubMed Central identifier	PMC7129549
has PubMed identifier	14623014
schema:publication	Microbes and Infection
resource representing a document's body	covid:9dfe72a2237c75f92ed14d15dcd22d3f4505edf8#body_text
is schema:about of	named entity 'ESCHERICHIA COLI' named entity 'located' named entity 'lesions' named entity 'loss' named entity 'inoculated' named entity 'calves' named entity 'pathogenicity' named entity 'toxins' named entity 'TYPE 2' named entity 'INFECTIONS' named entity 'ISOGENIC' named entity 'PATHOGENICITY' named entity 'ROLES' named entity 'IDENTIFIED' named entity 'WILD-TYPE STRAIN' named entity 'GENES' named entity 'DOES NOT' named entity 'REGARD' named entity 'AFFECTING' named entity 'MUTANT' named entity 'INTERNAL' named entity 'WAY' named entity 'PATHOGENIC' named entity 'PLASMID' named entity 'MUTANTS' named entity 'BLOODSTREAM' named entity 'INVASION' covid:arg/9dfe72a2237c75f92ed14d15dcd22d3f4505edf8 named entity 'INTESTINAL' named entity 'TOXINS' named entity 'SUCCESSFUL' named entity 'CALVES' named entity 'MUTANT STRAIN' named entity 'LESIONS' named entity 'NEWBORN' named entity 'MACROSCOPIC' named entity 'ASSOCIATED WITH' named entity 'THESE' named entity 'EXPERIMENTAL' named entity 'TOXINS' named entity 'RESTRICTED' named entity 'EVOLVED' named entity 'ORGANS' named entity 'INTESTINE' named entity 'NON-' named entity 'CALVES' named entity 'COLONIZATION' named entity 'STRAIN' named entity 'ESCHERICHIA COLI' named entity 'ORDER' named entity 'TRANSFERRED' named entity 'PROPERTIES' named entity 'EXTRA' named entity 'ROLES' named entity 'GENE' named entity 'ORALLY' named entity 'MICROSCOPIC' named entity 'TO LOCALIZE' named entity 'LOSS OF' named entity 'PATHOGENESIS' named entity 'DIARRHEA' named entity 'STRAINS' named entity 'OCCUR' named entity 'REDUCTION' named entity 'COLOSTRUM' named entity 'III' named entity 'CDT' named entity 'INVADE' named entity 'pathogenic' named entity 'plasmid' named entity 'inoculated' named entity 'Conversely' named entity 'isogenic' named entity 'diarrhea' named entity 'diarrhea' named entity 'intestinal' named entity 'toxins' named entity 'orally'

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