About: Thromboelastography Profiles of Critically Ill Patients With Coronavirus Disease 2019

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Thromboelastography Profiles of Critically Ill Patients With Coronavirus Disease 2019
Creator	Berger, Jeffrey Horowitz, James Yuriditsky, Eugene Ahuja, Tania Brosnahan, Shari Merchan, Cristian Mcvoy, Lauren
Source	Medline; PMC
abstract	OBJECTIVES: The rate of thromboembolic events among patients with coronavirus disease 2019 is high; however, there is no robust method to identify those at greatest risk. We reviewed thromboelastography studies in critically ill patients with coronavirus disease 2019 to characterize their coagulation states. DESIGN: Retrospective. SETTING: Tertiary ICU in New York City. PATIENTS: Sixty-four patients with coronavirus disease 2019 admitted to the ICU with thromboelastography performed. INTERVENTIONS: None. MEASUREMENTS AND MAIN RESULTS: Fifty percent of patients had a coagulation index in the hypercoagulable range (coagulation index > 3) (median 3.05). Reaction time and K values were below the lower limit of normal in 43.8% of the population consistent with a hypercoagulable profile. The median α angle and maximum amplitude (75.8° and 72.8 mm, respectively) were in the hypercoagulable range. The α angle was above reference range in 70.3% of patients indicative of rapid clot formation. Maximum amplitude, a factor of fibrinogen and platelet count and function, and a measure of clot strength was above reference range in 60.1% of patients. Thirty-one percent had thromboembolic events; thromboelastography parameters did not correlate with events in our cohort. Those with d-dimer values greater than 2,000 were more likely to have shorter reaction times compared with those with d-dimer levels less than or equal to 2,000 (4.8 vs 5.6 min; p = 0.001). CONCLUSIONS: A large proportion of critically ill patients with coronavirus disease 2019 have hypercoagulable thromboelastography profiles with additional derangements related to fibrinogen and platelet function. As the majority of patients have an elevated thromboelastography maximum amplitude, a follow-up study evaluating platelet aggregation would be instructive.
has issue date	2020-06-23(xsd:dateTime)
bibo:doi	10.1097/ccm.0000000000004471
bibo:pmid	32618696
has license	no-cc
sha1sum (hex)	9e6050492bc1183e0b532aaf95de5096c2afe2ca
schema:url	https://doi.org/10.1097/ccm.0000000000004471
resource representing a document's title	Thromboelastography Profiles of Critically Ill Patients With Coronavirus Disease 2019
has PubMed Central identifier	PMC7314320
has PubMed identifier	32618696
schema:publication	Crit Care Med
resource representing a document's body	covid:9e6050492bc1183e0b532aaf95de5096c2afe2ca#body_text
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