About: Double umbilical cord blood transplantation for children and adolescents

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Double umbilical cord blood transplantation for children and adolescents
Creator	Ahn, Hyo Kim, Lee, Ki Hoe, Hong Yoo, Ji Duk, Kyung Hyoung, Jin Kang, & Keon, Hee Lee, Hyery Soo, Hyun Woong, Sung Young, Hee
Source	PMC
abstract	Umbilical cord blood transplantation (UCBT) with two units has been conducted with promising results in adults to overcome the limitation of low cell numbers. In an attempt to improve the outcomes, double UCBT was performed in children and adolescents. Sixty-one patients, including 44 acute leukemia, and 17 other hematologic diseases, received double UCBT. Donor-type engraftment achieved in 82% of patients. Except one patient with persistent mixed chimerism of two units, other 49 patients showed dominancy of one unit and only the CFU-GM was significant factor influencing dominancy. The event-free survival (EFS) of leukemia and other hematologic disease were 59% and 53%, respectively, and the EFS of acute leukemia patients who received transplant in first or second CR (68.6%) was significantly better than in those with advanced disease (22.2%) (P = 0.007). Among the factors influencing outcomes, low cell dose difference between two units (TNC difference/TNC of large unit <15%) were associated with higher TRM, relapse, and lower EFS. Double UCBT was a promising modality of transplant in children and adolescence. However, engraftment and other results were not so satisfactory yet. To improve the outcomes, development of new selection guideline, probably including cell dose difference between two units and technology to enhance engraftment and reduce transplantation-related mortality are warranted.
has issue date	2010-05-28(xsd:dateTime)
bibo:doi	10.1007/s00277-010-0985-2
bibo:pmid	20508938
has license	no-cc
sha1sum (hex)	9ed53ff154d5ad29271f370763215fb8ffe453e6
schema:url	https://doi.org/10.1007/s00277-010-0985-2
resource representing a document's title	Double umbilical cord blood transplantation for children and adolescents
has PubMed Central identifier	PMC7101701
has PubMed identifier	20508938
schema:publication	Ann Hematol
resource representing a document's body	covid:9ed53ff154d5ad29271f370763215fb8ffe453e6#body_text
is schema:about of	named entity 'leukemia' named entity 'development' named entity 'influencing' named entity 'EFS' named entity 'PERFORMED' named entity 'HEMATOLOGIC DISEASE' named entity 'PROBABLY' named entity 'NEW' named entity 'DOUBLE' named entity 'UMBILICAL CORD BLOOD TRANSPLANTATION' named entity 'OUTCOMES' named entity 'TYPE' named entity 'DISEASE' named entity 'LOW' named entity 'patients' named entity 'advanced' named entity 'relapse' named entity 'acute leukemia' named entity 'improve' named entity 'improve' named entity 'promising' named entity 'EFS' named entity 'TNC' named entity 'transplant' named entity 'influencing' named entity 'Double' named entity 'acute leukemia' named entity 'factor' named entity 'CFU-GM' named entity 'Umbilical cord blood transplantation' named entity 'adolescence' named entity 'umbilical cord blood transplantation' named entity 'AML' named entity 'antigen' named entity 'prospective study' named entity 'Prophylaxis' named entity 'DRB1' named entity 'UCBT' named entity 'pediatric' named entity 'Korea' named entity 'risk factor' named entity 'chimerism' named entity 'osteopetrosis' named entity 'peripheral blood stem cell' named entity 'UCBT' named entity 'acute leukemia' named entity 'HLA' named entity 'Minnesota' named entity 'GVHD' named entity 'UCB' named entity 'bone marrow' named entity 'long-term' named entity '37 days' named entity 'leukemia' named entity 'HLA' named entity 'Minnesota' named entity 'cord blood' named entity 'graft-versus-leukemia effect' named entity 'platelet' named entity 'UCBT' named entity 'UCB' named entity 'EBV' named entity 'bone marrow' named entity 'antithymocyte globulin' named entity 'infection' named entity 'Foster City' named entity 'Minnesota' named entity 'DRB1' named entity 'cytomegalovirus'

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