About: Houttuynia cordata blocks HSV infection through inhibition of NF-κB activation

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Houttuynia cordata blocks HSV infection through inhibition of NF-κB activation
Creator	Wang, Jingjing Chen, Xiaoqing Li, Erguang Wang, Zhongxia Xu, Yunxia Yang, Ziying Tan, Ren-Xiang
Source	Elsevier; Medline; PMC
abstract	Abstract Houttuynia cordata Thunb. is a medicinal plant widely used in folk medicine in several Asian countries. It has been reported that a water extract of H. cordata exhibits activity against herpes simplex virus (HSV) and the virus of severe acute respiratory syndrome (SARS), although the mechanisms are not fully understood yet. Previous studies have demonstrated absolute requirement of NF-κB activation for efficient replication of HSV-1 and HSV-2 and inhibition of NF-κB activation has been shown to suppress HSV infection. Here we show that a hot water extract of H. cordata (HCWE) inhibits HSV-2 infection through inhibition of NF-κB activation. The IC50 was estimated at 50μg/ml of lyophilized HCWE powder. At 150 and 450μg/ml, HCWE blocked infectious HSV-2 production by more than 3 and 4 logs, respectively. The inhibitory activity was concomitant with an inhibition of NF-κB activation by HSV-2 infection. Although activation of NF-κB and Erk MAPK has been implicated for HSV replication and growth, HCWE showed no effect on HSV-2-induced Erk activation. Furthermore, we show that treatment with quercetin, quercitrin or isoquercitrin, major water extractable flavonoids from H. cordata, significantly blocked HSV-2 infection. These results together demonstrated that H. cordata blocks HSV-2 infection through inhibition of NF-κB activation.
has issue date	2011-11-30(xsd:dateTime)
bibo:doi	10.1016/j.antiviral.2011.09.005
bibo:pmid	21951655
has license	els-covid
sha1sum (hex)	9eec2605140f0856096789a10421729e4ba9d4e5
schema:url	https://doi.org/10.1016/j.antiviral.2011.09.005
resource representing a document's title	Houttuynia cordata blocks HSV infection through inhibition of NF-κB activation
has PubMed Central identifier	PMC7114259
has PubMed identifier	21951655
schema:publication	Antiviral Research
resource representing a document's body	covid:9eec2605140f0856096789a10421729e4ba9d4e5#body_text
is schema:about of	named entity 'replication' named entity 'infection' named entity 'activation' named entity 'inhibition' named entity 'Although' named entity 'HSV-2' named entity 'water' named entity 'Here' named entity 'activation' named entity 'INHIBITION' covid:arg/9eec2605140f0856096789a10421729e4ba9d4e5 named entity 'HOUTTUYNIA CORDATA' named entity 'ACTIVATION' named entity 'HOUTTUYNIA CORDATA THUNB.' named entity 'ESTIMATED' named entity 'HERE' named entity 'CONCOMITANT' named entity 'ERK ACTIVATION' named entity 'QUERCETIN' named entity 'HSV INFECTION' named entity 'REPLICATION' named entity 'HSV-2' named entity 'FOLK MEDICINE' named entity 'TREATMENT' named entity 'HSV INFECTION' named entity 'INDUCED' named entity 'LOGS' named entity 'NO EFFECT' named entity 'WATER' named entity 'REPORTED' named entity 'ERK MAPK' named entity 'ACTIVATION' named entity 'THESE' named entity 'INFECTIOUS' named entity 'MORE THAN' named entity 'DEMONSTRATED' named entity 'EXTRACT' named entity 'POWDER' named entity 'ABSOLUTE' named entity 'MECHANISMS' named entity 'VIRUS' named entity 'STUDIES' named entity 'UNDERSTOOD' named entity 'MEDICINAL PLANT' named entity 'HSV' named entity 'ISOQUERCITRIN' named entity 'INHIBITION' named entity 'BLOCKS' named entity 'HOT WATER EXTRACT' named entity '450' named entity 'SUPPRESS' named entity 'ASIAN COUNTRIES' named entity 'HAVE' named entity 'HERPES SIMPLEX VIRUS' named entity 'RESULTS' named entity 'INHIBITORY ACTIVITY' named entity 'PREVIOUS' named entity 'MAJOR' named entity 'HSV-1' named entity 'EFFICIENT' named entity 'USED' named entity '150' named entity 'PRODUCTION' named entity 'EXHIBITS' named entity 'IS A' named entity 'HSV-2 INFECTION' named entity 'SEVERE ACUTE RESPIRATORY SYNDROME' named entity 'BLOCKS' named entity 'REQUIREMENT' named entity 'FLAVONOIDS' named entity 'ACTIVITY' named entity 'FULLY' named entity 'GROWTH' named entity 'BLOCKED' named entity 'QUERCITRIN'

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