About: Autoimmunity and the microbiome: T‐cell receptor mimicry of “self” and microbial antigens mediates self tolerance in holobionts: The concepts of “holoimmunity” (TcR‐mediated tolerance for the holobiont) and “holoautoimmunity” (loss of tolerance for the holobiont) are introduced

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About: Autoimmunity and the microbiome: T‐cell receptor mimicry of “self” and microbial antigens mediates self tolerance in holobionts: The concepts of “holoimmunity” (TcR‐mediated tolerance for the holobiont) and “holoautoimmunity” (loss of tolerance for the holobiont) are introduced Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Autoimmunity and the microbiome: T‐cell receptor mimicry of “self” and microbial antigens mediates self tolerance in holobionts: The concepts of “holoimmunity” (TcR‐mediated tolerance for the holobiont) and “holoautoimmunity” (loss of tolerance for the holobiont) are introduced
source	PMC
abstract	I propose a T‐cell receptor (TcR)‐based mechanism by which immunity mediates both “genetic self” and “microbial self” thereby, connecting microbiome disease with autoimmunity. The hypothesis is based on simple principles. First, TcR are selected to avoid strong cross‐reactivity with “self,” resulting in selection for a TcR repertoire mimicking “genetic self.” Second, evolution has selected for a “microbial self” that mimics “genetic self” so as to share tolerance. In consequence, our TcR repertoire also mimics microbiome antigenicity, providing a novel mechanism for modulating tolerance to it. Also, the microbiome mimics the TcR repertoire, acting as a secondary immune system. I call this TcR‐microbiome mimicry “holoimmunity” to denote immune tolerance to the “holobiont self.” Logically, microbiome‐host mimicry means that autoimmunity directed at host antigens will also attack components of the microbiome, and conversely, an immunological attack on the microbiome may cross‐react with host antigens producing “holoautoimmunity.”
has issue date	2016-09-05(xsd:dateTime)
bibo:doi	10.1002/bies.201600083
bibo:pmid	27594308
has license	no-cc
sha1sum (hex)	9efc4877b92d275e9e3521891d856f79c080bb95
schema:url	https://doi.org/10.1002/bies.201600083
resource representing a document's title	Autoimmunity and the microbiome: T‐cell receptor mimicry of “self” and microbial antigens mediates self tolerance in holobionts: The concepts of “holoimmunity” (TcR‐mediated tolerance for the holobiont) and “holoautoimmunity” (loss of tolerance for the holobiont) are introduced
has PubMed Central identifier	PMC7161894
has PubMed identifier	27594308
schema:publication	Bioessays
resource representing a document's body	covid:9efc4877b92d275e9e3521891d856f79c080bb95#body_text
is schema:about of	named entity 'mimicry' named entity 'autoimmune diseases' named entity 'autoantigens' named entity 'T1DM' named entity 'microbiome' named entity 'infection' named entity 'autoantigens' named entity 'taxons' named entity 'coxsackie' named entity 'microbes' named entity 'Porphyromonas gingivalis' named entity 'BLAST search' named entity 'microbiome' named entity 'TcR' named entity 'TcR' named entity 'logical consequence' named entity 'autoimmune disease' named entity 'mimicry' named entity 'microbiome' named entity 'T1DM' named entity 'autoimmune diseases' named entity 'antigens' named entity 'antisense' named entity 'virally induced' named entity 'TcR' named entity 'interact' named entity 'antigens' named entity 'taxons' named entity 'mimicry' named entity 'pathogens' named entity 'cytomegalovirus' named entity 'flagellin' named entity 'inflammation' named entity 'infectious agents' named entity 'pathogenic microbes' named entity 'E. coli' named entity 'type 1 diabetes mellitus' named entity 'microbe' named entity 'anti-idiotype' named entity 'microbiome' named entity 'viruses' named entity 'antigens' named entity 'microbiome' named entity 'autoimmunity' named entity 'polio' named entity 'antigens' named entity 'autoimmune diseases' named entity 'peripheral blood' named entity 'TcR' named entity 'mimicry' named entity 'enteroviruses' named entity 'TcR' named entity 'physiological processes' named entity 'T1DM' named entity 'microbiome' named entity 'Clostridia' named entity 'TcR' named entity 'Jerne' named entity 'T1DM' named entity 'microbiome' named entity 'pathogens' named entity 'commensal' named entity 'autoimmune disease' named entity 'TcR' named entity 'type 1 diabetes mellitus' named entity 'holobiont' named entity 'T1DM' named entity 'Antigenic' named entity 'IgA antibodies' named entity 'immunological tolerance' named entity 'TcR' named entity 'virus' named entity 'antigens' named entity 'Bonferroni correction' named entity 'TcR' named entity 'antigenic diversity' named entity 'pathogen' named entity 'molecular complementarity' named entity 'TcR' named entity 'measles virus' named entity 'antibodies' named entity 'TcR'

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