About: Cytokine Profiles in Human Immunodeficiency Virus-Infected Children Treated With Highly Active Antiretroviral Therapy

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Cytokine Profiles in Human Immunodeficiency Virus-Infected Children Treated With Highly Active Antiretroviral Therapy
Creator	Lau, Yu-Lung Lim, Wilina Chiu, Susan Wong, Wilfred Chair, Jones, Brian
Source	Medline; PMC
abstract	CONTEXT: There have been few longitudinal studies of cytokine production in neonatally acquired HIV-1 infection and none in Asian or Chinese children. OBJECTIVE: To determine whether monitoring cytokine production could contribute to the better management of pediatric patients with HIV-1 infection. SETTING: Clinical Immunology Laboratory and Pediatrics Department, University Hospital, Hong Kong. PATIENTS: Ten Asian and 2 Eurasian children infected with HIV-1 by mother-to-child transmission were followed for up to 5 years while on treatment with highly active antiretroviral therapy (HAART). MAIN OUTCOME MEASURES: Numbers of unstimulated and mitogen-activated cytokine-secreting cells (IFN-gamma, interleukin [IL]-2, IL-4, IL-6, IL-10, IL-12, and TNF-alpha) were measured by ELISPOT assay at frequent intervals, and correlations were sought with CD4+ and CD8+ cell counts and viral loads. RESULTS: Mitogen-stimulated IL-2-secreting cells were directly associated with recovery of CD4+ cells. Correlations with viral load were found for Con A-induced IFN-gamma, Con A-induced IL-4, and unstimulated IL-10, suggesting that these cytokines were either suppressed by high virus levels or that higher cytokine levels suppressed virus. IFN-gamma, IL-2-, IL-4-, and IL-12-secreting cells induced by PHA, Con A, and/or SAC tended to increase for the first 3-4 years of treatment but declined thereafter. CONCLUSION: Alterations in cytokine profiles were not associated with adverse clinical events and there was little evidence to indicate that monitoring cytokine enzyme-linked immunospots (ELISPOTs) could contribute to pediatric patient management.
has issue date	2005-05-03(xsd:dateTime)
bibo:doi	10.1186/1758-2652-7-2-71
bibo:pmid	19825129
has license	no-cc
sha1sum (hex)	9f2eacde02bfd34993a2eab9d87c2643fcfd17e2
schema:url	https://doi.org/10.1186/1758-2652-7-2-71
resource representing a document's title	Cytokine Profiles in Human Immunodeficiency Virus-Infected Children Treated With Highly Active Antiretroviral Therapy
has PubMed Central identifier	PMC2759641
has PubMed identifier	19825129
schema:publication	J Int AIDS Soc
resource representing a document's body	covid:9f2eacde02bfd34993a2eab9d87c2643fcfd17e2#body_text
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is wasQuotedFrom of	covid:arg/9f2eacde02bfd34993a2eab9d87c2643fcfd17e2/0 covid:arg/9f2eacde02bfd34993a2eab9d87c2643fcfd17e2/1 covid:arg/9f2eacde02bfd34993a2eab9d87c2643fcfd17e2/2 covid:arg/9f2eacde02bfd34993a2eab9d87c2643fcfd17e2/3
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