About: Neutrophil to lymphocyte ratio as prognostic and predictive factor in patients with coronavirus disease 2019: A retrospective cross‐sectional study

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About: Neutrophil to lymphocyte ratio as prognostic and predictive factor in patients with coronavirus disease 2019: A retrospective cross‐sectional study Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Neutrophil to lymphocyte ratio as prognostic and predictive factor in patients with coronavirus disease 2019: A retrospective cross‐sectional study
Creator	Wang, Hua Gong, Wei Zhao, Jie Huang, Xin Li, Dongsheng Zhang, Yu-Jiao Nie, Shaoping Li, Fen Chen, \| Zheng, Wen Wang, \| Li, Yaping Yan, Jie Liu, Qiaomei Liu, Jianguang Md, Chen Deng, Yingzhong Dong, Xiaoyan Fen Zhu, \| Guan, Chaokun Haifeng, \| Shang, Jingzhou Tang, Shifan Yan, Xisheng Yu, Zhili Zeng, Lingjun
source	Medline; PMC
abstract	This retrospective study was designed to explore whether neutrophil to lymphocyte ratio (NLR) is a prognostic factor in patients with coronavirus disease 2019 (COVID‐19). A cohort of patients with COVID‐19 admitted to the Tongren Hospital of Wuhan University from 11 January 2020 to 3 March 2020 was retrospectively analyzed. Patients with hematologic malignancy were excluded. The NLR was calculated by dividing the neutrophil count by the lymphocyte count. NLR values were measured at the time of admission. The primary outcome was all‐cause in‐hospital mortality. A multivariate logistic analysis was performed. A total of 1004 patients with COVID‐19 were included in this study. The mortality rate was 4.0% (40 cases). The median age of nonsurvivors (68 years) was significantly older than survivors (62 years). Male sex was more predominant in nonsurvival group (27; 67.5%) than in the survival group (466; 48.3%). NLR value of nonsurvival group (median: 49.06; interquartile range [IQR]: 25.71‐69.70) was higher than that of survival group (median: 4.11; IQR: 2.44‐8.12; P < .001). In multivariate logistic regression analysis, after adjusting for confounding factors, NLR more than 11.75 was significantly correlated with all‐cause in‐hospital mortality (odds ratio = 44.351; 95% confidence interval = 4.627‐425.088). These results suggest that the NLR at hospital admission is associated with in‐hospital mortality among patients with COVID‐19. Therefore, the NLR appears to be a significant prognostic biomarker of outcomes in critically ill patients with COVID‐19. However, further investigation is needed to validate this relationship with data collected prospectively.
has issue date	2020-06-09(xsd:dateTime)
bibo:doi	10.1002/jmv.26061
bibo:pmid	32458459
has license	no-cc
sha1sum (hex)	9f5f3a14f584bdcd33ea19eb4bd08db7e9435795
schema:url	https://doi.org/10.1002/jmv.26061
resource representing a document's title	Neutrophil to lymphocyte ratio as prognostic and predictive factor in patients with coronavirus disease 2019: A retrospective cross‐sectional study
has PubMed Central identifier	PMC7283791
has PubMed identifier	32458459
schema:publication	J Med Virol
resource representing a document's body	covid:9f5f3a14f584bdcd33ea19eb4bd08db7e9435795#body_text
is schema:about of	named entity 'neutrophil' named entity 'COVID-19' named entity 'retrospective study' named entity '95%' named entity 'Male sex' named entity 'all-cause' named entity 'interquartile range' named entity 'hematological disorder' named entity 'NT-proBNP' named entity 'systemic corticosteroids' named entity 'health care workers' named entity 'systemic inflammatory' named entity 'ROC curve' named entity 'statistically significant' named entity 'antibiotic' named entity 'COVID' named entity 'clinical characteristics' named entity 'regression analysis' named entity 'digestive system diseases' named entity 'fatigue' named entity 'hazard ratio' named entity 'cerebrovascular diseases' named entity 'COVID' named entity 'comorbidities' named entity 'neutrophil' named entity 'lymphopenia' named entity '95% CI' named entity 'severe acute respiratory syndrome' named entity 'Chicago' named entity 'ROC curve' named entity 'COVID' named entity 'oseltamivir' named entity 'intensive care unit' named entity 'antiviral' named entity 'lymphocyte' named entity 'critically ill patients' named entity 'respiratory support' named entity 'area under the curve' named entity 'COVID' named entity 'long-term' named entity 'neutrophil' named entity 'COVID-19.' named entity 'computed tomography scan' named entity 'COVID-19' named entity 'fever' named entity 'respiratory failure' named entity 'viral pneumonia' named entity 'COVID' named entity 'World Health Organization' named entity 'confidence interval' named entity 'Tongren Hospital' named entity 'COVID-19' named entity 'NCIP' named entity 'COVID' named entity 'clinical outcomes' named entity 'biomarker'

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