About: Quantitative high throughput screening identifies inhibitors of anthrax-induced cell death

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: Quantitative high throughput screening identifies inhibitors of anthrax-induced cell death Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Quantitative high throughput screening identifies inhibitors of anthrax-induced cell death
Creator	Zhu, Ping Thomas, Craig Southall, Noel Zheng, Wei Inglese, James Liu, Shihui Lu, Jiamo Qiu, Cunping Bugge, Thomas Leppla, Stephen Austin, Christopher Hobson, John
source	Elsevier; Medline; PMC
abstract	Here, we report the results of a quantitative high-throughput screen (qHTS) measuring the endocytosis and translocation of a β-lactamase-fused-lethal factor and the identification of small molecules capable of obstructing the process of anthrax toxin internalization. Several small molecules protect RAW264.7 macrophages and CHO cells from anthrax lethal toxin and protected cells from an LF-Pseudomonas exotoxin fusion protein and diphtheria toxin. Further efforts demonstrated that these compounds impaired the PA heptamer pre-pore to pore conversion in cells expressing the CMG2 receptor, but not the related TEM8 receptor, indicating that these compounds likely interfere with toxin internalization.
has issue date	2009-07-01(xsd:dateTime)
bibo:doi	10.1016/j.bmc.2009.05.054
bibo:pmid	19540764
has license	green-oa
schema:url	https://doi.org/10.1016/j.bmc.2009.05.054
resource representing a document's title	Quantitative high throughput screening identifies inhibitors of anthrax-induced cell death
has PubMed Central identifier	PMC2795356
has PubMed identifier	19540764
schema:publication	Bioorganic & Medicinal Chemistry
resource representing a document's body	covid:PMC2795356#body_text
is schema:about of	named entity 'Hill equation' named entity 'phenylalanine' named entity 'toxin' named entity 'B/G' named entity '37 °C' named entity 'endospores' named entity 'PerkinElmer' named entity 'data analysis' named entity 'diphtheria toxin' named entity 'CHO' named entity 'SARS' named entity 'cytoplasm' named entity 'catalytic domain' named entity 'serially diluted' named entity 'heptamer' named entity 'NIH' named entity 'CMG2' named entity 'fluorescent' named entity 'CHO' named entity 'combinatorial libraries' named entity 'TEM8' named entity 'screening assay' named entity 'archaebacteria' named entity 'SDS' named entity 'epifluorescence microscopy' named entity 'anthrax toxin' named entity 'bioterrorism' named entity 'endocytosis' named entity 'EC50' named entity 'V-ATPase' named entity 'small molecules' named entity 'kinase inhibitor' named entity 'B. anthracis' named entity 'fluorescence' named entity 'V-ATPase' named entity 'viral entry' named entity 'Rockingham, VT' named entity 'niclosamide' named entity 'follow-up' named entity 'V-ATPase' named entity 'toxin' named entity 'Newark, DE' named entity 'fluorophore' named entity 'growth medium' named entity 'Diphyllin' named entity 'High-throughput screening' named entity 'cell lines' named entity 'TEM8' named entity 'macrophages' named entity 'ammonium chloride' named entity 'antigen' named entity 'niclosamide' named entity 'Small Molecule' named entity 'Invitrogen' named entity 'ester' named entity 'toxin' named entity 'cucurbitacin' named entity 'proscillaridin' named entity 'non-specific' named entity 'isopropyl alcohol' named entity 'fluorescence' named entity 'enzyme' named entity 'macrophages' named entity 'biosafety level' named entity 'fluorescence' named entity 'PubChem' named entity 'CHO' named entity 'biosafety level' named entity 'tumor' named entity 'fluorescence' named entity 'HTS'

Faceted Search & Find service v1.13.91 as of Mar 24 2020

Alternative Linked Data Documents: Sponger | ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3229 as of Jul 10 2020, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (94 GB total memory)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2025 OpenLink Software