About: Comparative Analysis of Ebola Virus Glycoprotein Interactions With Human and Bat Cells

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Comparative Analysis of Ebola Virus Glycoprotein Interactions With Human and Bat Cells
Creator	Herrler, Georg Drosten, Christian Munster, Vincent Feldmann, Heinz Pöhlmann, Stefan Hoffmann, Markus Gnirß, Kerstin Kühl, Annika Behrens, Georg Kiene, Miriam Müller, Marcel Tsegaye, Theodros
source	Medline; PMC
abstract	Infection with Ebola virus (EBOV) causes hemorrhagic fever in humans with high case-fatality rates. The EBOV-glycoprotein (EBOV-GP) facilitates viral entry and promotes viral release from human cells. African fruit bats are believed not to develop disease upon EBOV infection and have been proposed as a natural reservoir of EBOV. We compared EBOV-GP interactions with human cells and cells from African fruit bats. We found that susceptibility to EBOV-GP–dependent infection was not limited to bat cells from potential reservoir species, and we observed that GP displayed similar biological properties in human and bat cells. The only exception was GP localization, which was to a greater extent intracellular in bat cells as compared to human cells. Collectively, our results suggest that GP interactions with fruit bat and human cells are similar and do not limit EBOV tropism for certain bat species.
has issue date	2011-11-01(xsd:dateTime)
bibo:doi	10.1093/infdis/jir306
bibo:pmid	21987760
has license	bronze-oa
schema:url	https://doi.org/10.1093/infdis/jir306
resource representing a document's title	Comparative Analysis of Ebola Virus Glycoprotein Interactions With Human and Bat Cells
has PubMed Central identifier	PMC3189982
has PubMed identifier	21987760
schema:publication	The Journal of Infectious Diseases
resource representing a document's body	covid:PMC3189982#body_text
is schema:about of	named entity 'Virus' named entity 'Virus' named entity 'Bat' named entity 'kidney cells' named entity 'tetherin' named entity 'glycoprotein' named entity 'viral budding' named entity 'cell culture' named entity '293T' named entity 'VP40' named entity 'gene' named entity 'reservoir species' named entity 'nuclei' named entity 'EBOV' named entity 'EBOV' named entity '293T cells' named entity 'inoculum' named entity 'antiviral' named entity 'cell lines' named entity 'ZEBOV' named entity 'EBOV' named entity 'BSL4' named entity 'VP40' named entity 'EBOV' named entity 'paraformaldehyde' named entity 'cloned' named entity '293T cells' named entity 'plasmids' named entity 'EBOV' named entity 'Western blotting' named entity 'viral budding' named entity 'plasma membrane' named entity 'bat' named entity 'bat' named entity 'buffered solution' named entity 'supernatant' named entity 'plasmids' named entity 'VP40' named entity 'cell surface' named entity 'EBOV' named entity 'EBOV' named entity 'open reading frame' named entity 'BHK' named entity 'reservoir species' named entity 'BMBF' named entity 'ZEBOV' named entity 'EBOV' named entity 'kidney' named entity 'EcoRI' named entity 'transfected' named entity 'ZEBOV' named entity 'human embryonic kidney cell' named entity 'bat' named entity 'infection' named entity 'reservoir species' named entity 'reservoir species' named entity 'fetal' named entity 'infection' named entity 'furin' named entity 'EBOV' named entity 'VP40' named entity 'African fruit bats' named entity 'transfected' named entity 'transfected' named entity 'bat' named entity 'bat' named entity 'transfected' named entity 'insectivorous bat' named entity 'pro-protein' named entity 'c-myc' named entity 'EBOV'

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