About: Probable person to person transmission of novel avian influenza A (H7N9) virus in Eastern China, 2013: epidemiological investigation

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About: Probable person to person transmission of novel avian influenza A (H7N9) virus in Eastern China, 2013: epidemiological investigation Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Probable person to person transmission of novel avian influenza A (H7N9) virus in Eastern China, 2013: epidemiological investigation
Creator	Wang, Hua Huang, Yong Xu, Ke Qi, Xian Zhu, Feng-Cai Ji, Hong Lu, Bing Bao, Chang-Jun Cai, Pei-Quan Cui, Lun-Biao Guo, Xi-Ling Qian, Yan-Hua Shi, Chao Tang, Fen-Yang Zhou, Ming-Hao
source	Medline; PMC
abstract	Objective To determine whether the novel avian influenza H7N9 virus can transmit from person to person and its efficiency. Design Epidemiological investigations conducted after a family cluster of two patients with avian H7N9 in March 2013. Setting Wuxi, Eastern China. Participants Two patients, their close contacts, and relevant environments. Samples from the patients and environments were collected and tested by real time reverse transcriptase-polymerase chain reaction (rRT-PCR), viral culture, and haemagglutination inhibition assay. Any contacts who became ill had samples tested for avian H7N9 by rRT-PCR. Paired serum samples were obtained from contacts for serological testing by haemagglutination inhibition assays. Main outcomes measures Clinical data, history of exposure before the onset of illnesses, and results of laboratory testing of pathogens and further analysis of sequences and phylogenetic tree to isolated strains. Results The index patient became ill five to six days after his last exposure to poultry. The second patient, his daughter aged 32, who provided unprotected bedside care in the hospital, had no known exposure to poultry. She developed symptoms six days after her last contact with her father. Two strains were isolated successfully from the two patients. Genome sequence and analyses of phylogenetic trees showed that both viruses were almost genetically identical. Forty three close contacts of both patients were identified. One had mild illness but had negative results for avian H7N9 by rRT-PCR. All 43 close contacts tested negative for haemagglutination inhibition antibodies specific for avian H7N9. Conclusions The infection of the daughter probably resulted from contact with her father (the index patient) during unprotected exposure, suggesting that in this cluster the virus was able to transmit from person to person. The transmissibility was limited and non-sustainable.
has issue date	2013-08-06(xsd:dateTime)
bibo:doi	10.1136/bmj.f4752
bibo:pmid	23920350
has license	cc-by-nc
schema:url	https://doi.org/10.1136/bmj.f4752
resource representing a document's title	Probable person to person transmission of novel avian influenza A (H7N9) virus in Eastern China, 2013: epidemiological investigation
has PubMed Central identifier	PMC3805478
has PubMed identifier	23920350
schema:publication	BMJ
resource representing a document's body	covid:PMC3805478#body_text
is schema:about of	named entity 'VIRUS' named entity 'CHINA' named entity 'INVESTIGATION' named entity 'PROBABLE' named entity 'AVIAN INFLUENZA A' named entity 'NOVEL' named entity 'TRANSMISSION' named entity 'EPIDEMIOLOGICAL' named entity 'EASTERN' named entity 'PERSON' named entity 'H7N9' named entity 'epidemiological' named entity 'avian influenza' named entity 'virus' named entity 'antibiotics' named entity 'H7N9' named entity 'Public health' named entity 'phylogenetic analysis' named entity 'Life Technologies' named entity 'H9N2' named entity '2 April' named entity 'index patient' named entity 'March 11' named entity 'infectious disease' named entity 'viruses' named entity 'rRT-PCR' named entity 'intensive care' named entity 'transmissibility' named entity 'serum samples' named entity 'index patient' named entity '15 March' named entity '21 March' named entity 'DNASTAR' named entity '15 March' named entity 'MDCK' named entity 'nucleotide' named entity 'sulbactam' named entity 'cell lines' named entity 'H7N9' named entity 'interspecies transmission' named entity 'expectoration' named entity 'BSL-3' named entity 'antibodies' named entity 'medical records' named entity 'property management' named entity 'viruses' named entity 'sulbactam' named entity 'poultry' named entity 'azithromycin' named entity 'pigeon' named entity 'Life Technologies' named entity 'poultry' named entity 'severe pneumonia' named entity 'broad spectrum antibiotics' named entity 'respiratory failure' named entity 'lymphopenia' named entity 'H5N1' named entity 'Jiangsu' named entity 'genomes' named entity '4 May' named entity 'viral genomes' named entity 'genetic distance' named entity 'upper lobe' named entity 'fowl' named entity 'multi-organ failure' named entity 'asymptomatic' named entity 'San Diego' named entity 'tertiary hospital'

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