About: Potential benefits of precise corticosteroids therapy for severe 2019-nCoV pneumonia

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Potential benefits of precise corticosteroids therapy for severe 2019-nCoV pneumonia
Creator	Cheng, Jing Hu, Ming Zhou, Wei Fang, Minghao Wang, Cheng Gao, Yue Liu, Yisi Tian, Dongdong Wang, Sa
Source	Medline; PMC; WHO
abstract	Salvage corticosteroids treatment for critical patients with 2019-nCoV? Corticosteroids are widely used to prevent lung injury caused by severe community-acquired pneumonia (sCAP) due to their excellent pharmacological effects on the suppression of exuberant and dysfunctional systematic inflammation5. Some scholars may not support the corticosteroids treatment for novel coronavirus pneumonia (NCP), because observational studies and systematic reviews have indicated inconclusive clinical evidence on the effect of corticosteroids therapy for viral pneumonias (such as SARS, MERS and H1N1). Additionally, pulse-dose therapy or long-term administration to high dose of corticosteroids in early stage were reported to be possibly harmful6,7,8. However, these conclusions obscured the clinical benefits of corticosteroids on some subgroups of patients, particularly those with severe symptoms, as the clinical effects might be related to the indication (severities of illness), the timing of intervention, the dose and duration of corticosteroids therapy9.
has issue date	2020-02-21(xsd:dateTime)
bibo:doi	10.1038/s41392-020-0127-9
bibo:pmid	32133159
has license	cc-by
schema:url	https://doi.org/10.1038/s41392-020-0127-9
resource representing a document's title	Potential benefits of precise corticosteroids therapy for severe 2019-nCoV pneumonia
has PubMed Central identifier	PMC7035340
has PubMed identifier	32133159
schema:publication	Signal Transduct Target Ther
resource representing a document's body	covid:PMC7035340#body_text
is schema:about of	named entity '2019-nCoV' named entity 'PNEUMONIA' named entity 'pneumonia' named entity 'randomized clinical trials' named entity 'corticosteroids' named entity 'corticosteroids' named entity 'ICU' named entity 'clinical experience' named entity 'lung injury' named entity 'invasive mechanical ventilation' named entity 'NCP' named entity 'lung infections' named entity 'ARDS' named entity 'SARS' named entity 'corticosteroids' named entity 'hyperglycemia' named entity 'NCP' named entity 'corticosteroids' named entity 'hypoxemia' named entity 'treatment group' named entity 'bilateral pneumonia' named entity 'long-term' named entity '2019-nCoV' named entity 'Wuhan' named entity 'NCP' named entity 'NCP' named entity 'corticosteroids' named entity 'NCP' named entity 'high dose' named entity 'corticosteroids' named entity 'septic shock' named entity 'clinical evidence' named entity 'ICU' named entity 'ICU' named entity 'inflammation' named entity '2019-nCoV' named entity 'avascular' named entity 'systematic reviews' named entity 'antiviral agents' named entity 'infection' named entity 'ARDS' named entity 'critically ill patients' named entity '2019-nCoV' named entity 'corticosteroids' named entity 'oxygen therapy' named entity 'pharmacological' named entity 'H1N1' named entity 'World Health Organization' named entity 'sCAP' named entity 'synergistic' named entity 'corticosteroids' named entity 'equivalent dose' named entity 'corticosteroids' named entity 'therapeutic process' named entity 'SARS' named entity 'Corticosteroids' named entity 'prospective cohort study' named entity 'adverse effects' named entity '2019-nCoV' named entity 'corticosteroids' named entity 'psychosis' named entity 'sCAP' named entity 'WHO' named entity 'sepsis' named entity 'IMV' named entity 'hypoxemia' named entity 'SARS' named entity 'hydrocortisone' named entity 'long-term' named entity 'body weight' named entity 'NCP' named entity '2019-nCoV' named entity 'virus' named entity 'PaO2'

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