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About:
Porcine epidemic diarrhea virus virus-like particles produced in insect cells induce specific immune responses in mice
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An Entity of Type :
schema:ScholarlyArticle
, within Data Space :
wasabi.inria.fr
associated with source
document(s)
Type:
Academic Article
research paper
schema:ScholarlyArticle
New Facet based on Instances of this Class
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type
Academic Article
research paper
schema:ScholarlyArticle
isDefinedBy
Covid-on-the-Web dataset
has title
Porcine epidemic diarrhea virus virus-like particles produced in insect cells induce specific immune responses in mice
Creator
Xia, Xianzhu
Yang, Songtao
Wang, Chong
Feng, Na
Gao, Yuwei
Wang, Hualei
Wang, Tiecheng
Zhao, Yongkun
Zheng, Xuexing
Jin, Hongli
Yan, Feihu
Wang, Cuiling
Source
Medline; PMC
abstract
Porcine epidemic diarrhea virus (PEDV), which causes 80–100% mortality in neonatal piglets, is one of the most devastating viral diseases affecting swine worldwide. To date, the lack of effective vaccines and drugs is the main problem preventing control of the global spread of PEDV. In this study, we produced PEDV virus-like particles (VLPs) composed of S, M, and E proteins with a baculovirus expression system and tested them via indirect immunofluorescence assay (IFA)and Western blot analysis. Electron microscopy showed that the morphological structure of the PEDV VLPs was similar to that of the protovirus. Microneutralization assays and ELISpot analysis demonstrated that PEDV VLPs induced highly specific antibody responses and Th2-mediated humoral immunity. As a result, the PEDV VLPs displayed excellent immunogenicity in mice. Therefore, a VLP-based vaccine has the potential to prevent PEDV infection.
has issue date
2017-03-29
(
xsd:dateTime
)
bibo:doi
10.1007/s11262-017-1450-2
bibo:pmid
28357676
has license
no-cc
schema:url
https://doi.org/10.1007/s11262-017-1450-2
resource representing a document's title
Porcine epidemic diarrhea virus virus-like particles produced in insect cells induce specific immune responses in mice
has PubMed Central identifier
PMC7088547
has PubMed identifier
28357676
schema:publication
Virus Genes
resource representing a document's body
covid:PMC7088547#body_text
is
schema:about
of
named entity 'induce'
named entity 'PORCINE EPIDEMIC DIARRHEA VIRUS'
named entity 'INSECT'
named entity 'SPECIFIC'
named entity 'IMMUNE RESPONSES'
named entity 'INDUCE'
named entity 'VIRUS-LIKE PARTICLES'
named entity 'MICE'
named entity 'CELLS'
named entity 'insect'
named entity 'virus-like particles'
named entity 'TCID50'
named entity 'adjuvant'
named entity 'IL-4'
named entity 'sucrose'
named entity 'swine'
named entity 'immunogenicity'
named entity 'ANOVA'
named entity 'recombinant'
named entity 'VLPs'
named entity 'humoral immune responses'
named entity 'influenza virus'
named entity 'antibody'
named entity 'immunopathology'
named entity 'mice'
named entity 'vaccine'
named entity 'Grand Island'
named entity 'virus'
named entity 'recombinant'
named entity 'virus'
named entity 'serum'
named entity 'PEDV'
named entity 'Vero'
named entity 'statistical analysis'
named entity 'hpi'
named entity 'porcine'
named entity 'ELISpot'
named entity 'genus'
named entity 'Live-attenuated'
named entity 'structural proteins'
named entity 'protein'
named entity 'virus-like particles'
named entity 'SDS-PAGE'
named entity 'PEDV'
named entity 'PEDV'
named entity 'vaccination'
named entity 'VLPs'
named entity 'positive-sense RNA genome'
named entity 'BALB/c'
named entity 'nanoparticles'
named entity 'Stockholm'
named entity 'Sf9'
named entity 'VLPs'
named entity 'IFN-γ'
named entity 'PEDV'
named entity 'transfected'
named entity 'statistical significance'
named entity 'transfecting'
named entity 'inactivated vaccine'
named entity 'swine'
named entity 'Virus-like particles'
named entity 'subunit protein'
named entity 'Sweden'
named entity 'epitopes'
named entity 'spike (S) protein'
named entity '0.01'
named entity 'VLPs'
named entity 'PEDV'
named entity 'antigen-antibody complex'
named entity 'North America'
named entity 'VLPs'
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