About: Porcine epidemic diarrhea virus virus-like particles produced in insect cells induce specific immune responses in mice

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Porcine epidemic diarrhea virus virus-like particles produced in insect cells induce specific immune responses in mice
Creator	Xia, Xianzhu Yang, Songtao Wang, Chong Feng, Na Gao, Yuwei Wang, Hualei Wang, Tiecheng Zhao, Yongkun Zheng, Xuexing Jin, Hongli Yan, Feihu Wang, Cuiling
Source	Medline; PMC
abstract	Porcine epidemic diarrhea virus (PEDV), which causes 80–100% mortality in neonatal piglets, is one of the most devastating viral diseases affecting swine worldwide. To date, the lack of effective vaccines and drugs is the main problem preventing control of the global spread of PEDV. In this study, we produced PEDV virus-like particles (VLPs) composed of S, M, and E proteins with a baculovirus expression system and tested them via indirect immunofluorescence assay (IFA)and Western blot analysis. Electron microscopy showed that the morphological structure of the PEDV VLPs was similar to that of the protovirus. Microneutralization assays and ELISpot analysis demonstrated that PEDV VLPs induced highly specific antibody responses and Th2-mediated humoral immunity. As a result, the PEDV VLPs displayed excellent immunogenicity in mice. Therefore, a VLP-based vaccine has the potential to prevent PEDV infection.
has issue date	2017-03-29(xsd:dateTime)
bibo:doi	10.1007/s11262-017-1450-2
bibo:pmid	28357676
has license	no-cc
schema:url	https://doi.org/10.1007/s11262-017-1450-2
resource representing a document's title	Porcine epidemic diarrhea virus virus-like particles produced in insect cells induce specific immune responses in mice
has PubMed Central identifier	PMC7088547
has PubMed identifier	28357676
schema:publication	Virus Genes
resource representing a document's body	covid:PMC7088547#body_text
is schema:about of	named entity 'induce' named entity 'PORCINE EPIDEMIC DIARRHEA VIRUS' named entity 'INSECT' named entity 'SPECIFIC' named entity 'IMMUNE RESPONSES' named entity 'INDUCE' named entity 'VIRUS-LIKE PARTICLES' named entity 'MICE' named entity 'CELLS' named entity 'insect' named entity 'virus-like particles' named entity 'TCID50' named entity 'adjuvant' named entity 'IL-4' named entity 'sucrose' named entity 'swine' named entity 'immunogenicity' named entity 'ANOVA' named entity 'recombinant' named entity 'VLPs' named entity 'humoral immune responses' named entity 'influenza virus' named entity 'antibody' named entity 'immunopathology' named entity 'mice' named entity 'vaccine' named entity 'Grand Island' named entity 'virus' named entity 'recombinant' named entity 'virus' named entity 'serum' named entity 'PEDV' named entity 'Vero' named entity 'statistical analysis' named entity 'hpi' named entity 'porcine' named entity 'ELISpot' named entity 'genus' named entity 'Live-attenuated' named entity 'structural proteins' named entity 'protein' named entity 'virus-like particles' named entity 'SDS-PAGE' named entity 'PEDV' named entity 'PEDV' named entity 'vaccination' named entity 'VLPs' named entity 'positive-sense RNA genome' named entity 'BALB/c' named entity 'nanoparticles' named entity 'Stockholm' named entity 'Sf9' named entity 'VLPs' named entity 'IFN-γ' named entity 'PEDV' named entity 'transfected' named entity 'statistical significance' named entity 'transfecting' named entity 'inactivated vaccine' named entity 'swine' named entity 'Virus-like particles' named entity 'subunit protein' named entity 'Sweden' named entity 'epitopes' named entity 'spike (S) protein' named entity '0.01' named entity 'VLPs' named entity 'PEDV' named entity 'antigen-antibody complex' named entity 'North America' named entity 'VLPs'

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