About: Host Cell Mimic Polymersomes for Rapid Detection of Highly Pathogenic Influenza Virus via a Viral Fusion and Cell Entry Mechanism

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About: Host Cell Mimic Polymersomes for Rapid Detection of Highly Pathogenic Influenza Virus via a Viral Fusion and Cell Entry Mechanism Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Host Cell Mimic Polymersomes for Rapid Detection of Highly Pathogenic Influenza Virus via a Viral Fusion and Cell Entry Mechanism
Creator	Kim, Jihye Song, Daesub Na, Woonsung Yeom, Minjoo Choi, Jihye Kim, Jeong‐Ki Jeong, Dae Lee, Jae Haam, Seungjoo Le, Van Park, Chaewon Park, Geunseon Chun, Haejin Jeong, Hyoung Kim, Hyun‐Ouk Lee, Kwangyeol Lim, Jong‐Woo Yun, Dayeon
Source	PMC
abstract	Highly pathogenic avian influenza virus (HPAIV) infections have occurred continuously and crossed the species barrier to humans, leading to fatalities. A polymerase chain reaction based molecular test is currently the most sensitive diagnostic tool for HPAIV; however, the results must be analyzed in centralized diagnosis systems by a trained individual. This requirement leads to delays in quarantine and isolation. To control the spread of HPAIV, rapid and accurate diagnostics suitable for field testing are needed, and the tests must facilitate a differential diagnosis between HPAIV and low pathogenic avian influenza virus (LPAIV), which undergo cleavage specifically by trypsin‐ or furin‐like proteases, respectively. In this study, a differential avian influenza virus rapid test kit is developed and evaluated in vitro and using clinical specimens from HPAIV H5N1‐infected animals. It is demonstrated that this rapid test kit provides highly sensitive and specific detection of HPAIV and LPAIV and is thus a useful field diagnostic tool for H5N1 HPAIV outbreaks and for rapid quarantine control of the disease.
has issue date	2018-06-25(xsd:dateTime)
bibo:doi	10.1002/adfm.201800960
has license	no-cc
schema:url	https://doi.org/10.1002/adfm.201800960
resource representing a document's title	Host Cell Mimic Polymersomes for Rapid Detection of Highly Pathogenic Influenza Virus via a Viral Fusion and Cell Entry Mechanism
has PubMed Central identifier	PMC7161833
schema:publication	Adv Funct Mater
resource representing a document's body	covid:PMC7161833#body_text
is schema:about of	named entity 'Pathogenic' named entity 'Viral' named entity 'Virus' named entity 'Influenza Virus' named entity 'Viral' named entity 'FRET' named entity 'FRET' named entity 'FRET' named entity 'furin' named entity 'operation time' named entity 'H5N2' named entity 'proteases' named entity 'FRET' named entity 'calcein' named entity '5.0' named entity 'Methoxy' named entity 'proteases' named entity 'α-helices' named entity 'FRET' named entity 'FRET' named entity 'host cell' named entity 'H3N2' named entity 'FRET' named entity 'influenza virus' named entity 'DiO' named entity 'membrane fusion' named entity 'cell membranes' named entity 'fluorescence' named entity 'fluorescence' named entity 'trypsin' named entity 'DiO' named entity 'H3N2' named entity 'South Korea' named entity 'α-helical' named entity 'TEM' named entity 'influenza virus' named entity 'hemagglutinin' named entity 'FRET' named entity 'round-bottom flask' named entity 'nasal swab' named entity 'membrane fusion' named entity 'FRET' named entity 'FRET' named entity 'FRET' named entity 'FRET' named entity 'fluorescence resonance energy transfer' named entity 'Vietnam' named entity 'hydrophilic' named entity 'copolymer' named entity 'amino acids' named entity 'virus' named entity 'FRET' named entity 'hydrophilic' named entity 'trypsin' named entity 'DiO' named entity 'FRET' named entity 'chicken' named entity 'influenza outbreaks' named entity 'California' named entity 'RT-PCR' named entity 'proteases' named entity 'vesicle' named entity 'enzyme' named entity 'furin' named entity 'amino acids' named entity 'trypsin' named entity 'influenza virus'

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