About: Viral load dynamics and disease severity in patients infected with SARS-CoV-2 in Zhejiang province, China, January-March 2020: retrospective cohort study

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About: Viral load dynamics and disease severity in patients infected with SARS-CoV-2 in Zhejiang province, China, January-March 2020: retrospective cohort study Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Viral load dynamics and disease severity in patients infected with SARS-CoV-2 in Zhejiang province, China, January-March 2020: retrospective cohort study
Creator	Zhang, Jinming Wang, Qi Chen, Yu Yu, Fei Sheng, Jifang Fan, Jian Xie, Guoliang Yang, Xianzhi Zheng, Shufa Zhang, Dan Fang, Qiang Xu, Kaijin Cai, Hongliu Liang, Tingbo Qiu, Yunqing Wei, Guoqing Zhou, Jianying Yao, Hangping Lin, Sha Lou, Bin Feng, Baihuan Lu, Xiaoyang Wang, Ruonan Zou, Qianda Chen, Weizhen Gong, Renjie Gu, Yaxi Liu, Yanchao Lu, Siming Ma, Zhaohui Xiao, Yanyan
source	Medline; PMC
abstract	OBJECTIVE: To evaluate viral loads at different stages of disease progression in patients infected with the 2019 severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) during the first four months of the epidemic in Zhejiang province, China. DESIGN: Retrospective cohort study. SETTING: A designated hospital for patients with covid-19 in Zhejiang province, China. PARTICIPANTS: 96 consecutively admitted patients with laboratory confirmed SARS-CoV-2 infection: 22 with mild disease and 74 with severe disease. Data were collected from 19 January 2020 to 20 March 2020. MAIN OUTCOME MEASURES: Ribonucleic acid (RNA) viral load measured in respiratory, stool, serum, and urine samples. Cycle threshold values, a measure of nucleic acid concentration, were plotted onto the standard curve constructed on the basis of the standard product. Epidemiological, clinical, and laboratory characteristics and treatment and outcomes data were obtained through data collection forms from electronic medical records, and the relation between clinical data and disease severity was analysed. RESULTS: 3497 respiratory, stool, serum, and urine samples were collected from patients after admission and evaluated for SARS-CoV-2 RNA viral load. Infection was confirmed in all patients by testing sputum and saliva samples. RNA was detected in the stool of 55 (59%) patients and in the serum of 39 (41%) patients. The urine sample from one patient was positive for SARS-CoV-2. The median duration of virus in stool (22 days, interquartile range 17-31 days) was significantly longer than in respiratory (18 days, 13-29 days; P=0.02) and serum samples (16 days, 11-21 days; P<0.001). The median duration of virus in the respiratory samples of patients with severe disease (21 days, 14-30 days) was significantly longer than in patients with mild disease (14 days, 10-21 days; P=0.04). In the mild group, the viral loads peaked in respiratory samples in the second week from disease onset, whereas viral load continued to be high during the third week in the severe group. Virus duration was longer in patients older than 60 years and in male patients. CONCLUSION: The duration of SARS-CoV-2 is significantly longer in stool samples than in respiratory and serum samples, highlighting the need to strengthen the management of stool samples in the prevention and control of the epidemic, and the virus persists longer with higher load and peaks later in the respiratory tissue of patients with severe disease.
has issue date	2020-04-21(xsd:dateTime)
bibo:doi	10.1136/bmj.m1443
bibo:pmid	32317267
has license	cc-by-nc
schema:url	https://doi.org/10.1136/bmj.m1443
resource representing a document's title	Viral load dynamics and disease severity in patients infected with SARS-CoV-2 in Zhejiang province, China, January-March 2020: retrospective cohort study
has PubMed Central identifier	PMC7190077
has PubMed identifier	32317267
schema:publication	BMJ
resource representing a document's body	covid:PMC7190077#body_text
is schema:about of	named entity 'Viral load' named entity 'MARCH' named entity 'retrospective cohort study' named entity 'SARS-CoV-2' named entity 'sputum' named entity 'SARS-CoV-2' named entity 'detection limit' named entity 'SARS-CoV-2' named entity 'disease control' named entity 'significant difference' named entity 'R software' named entity 'serum samples' named entity 'PCR' named entity 'virus' named entity 'viral load' named entity 'virus' named entity 'saliva' named entity 'prevent the spread' named entity 'critically ill' named entity 'dyspnoea' named entity 'headache' named entity 'infection' named entity 'electronic medical records' named entity 'SARS-CoV-2' named entity 'clinical treatment' named entity 'diabetes mellitus' named entity 'nucleic acid' named entity 'cohort study' named entity 'sputum' named entity 'glucocorticoids' named entity 'viral load' named entity 'viral load' named entity 'antiviral' named entity 'cough' named entity 'People’s Republic of China' named entity 'virus' named entity 'sample size' named entity 'analysis of variance' named entity 'Viral load' named entity 'loess' named entity 'fever' named entity 'virus' named entity 'urine' named entity 'tissue samples' named entity 'viral shedding' named entity 'serum' named entity 'blood collection' named entity 'viral load' named entity 'virus' named entity 'prevention and control' named entity 'blood oxygen saturation' named entity 'skewed distribution'

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