About: COVID-19 pandemic and admission rates for and management of acute coronary syndromes in England

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Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	COVID-19 pandemic and admission rates for and management of acute coronary syndromes in England
Creator	Luescher, Thomas Casadei, Barbara Deanfield, John Gale, Chris Mamas, Mamas Baigent, Colin Bray, Mark Collins, Rory Curnow, Paula Denwood, Tom Emberson, Jonathan Gair, Dominic Goldacre, Raphael Hollings, Sam Landray, Martin Mafham, Marion Morris, Eva Roebuck, Chris Spata, Enti de Belder, Mark
Source	Medline; PMC
abstract	BACKGROUND: Several countries affected by the COVID-19 pandemic have reported a substantial drop in the number of patients attending the emergency department with acute coronary syndromes and a reduced number of cardiac procedures. We aimed to understand the scale, nature, and duration of changes to admissions for different types of acute coronary syndrome in England and to evaluate whether in-hospital management of patients has been affected as a result of the COVID-19 pandemic. METHODS: We analysed data on hospital admissions in England for types of acute coronary syndrome from Jan 1, 2019, to May 24, 2020, that were recorded in the Secondary Uses Service Admitted Patient Care database. Admissions were classified as ST-elevation myocardial infarction (STEMI), non-STEMI (NSTEMI), myocardial infarction of unknown type, or other acute coronary syndromes (including unstable angina). We identified revascularisation procedures undertaken during these admissions (ie, coronary angiography without percutaneous coronary intervention [PCI], PCI, and coronary artery bypass graft surgery). We calculated the numbers of weekly admissions and procedures undertaken; percentage reductions in weekly admissions and across subgroups were also calculated, with 95% CIs. FINDINGS: Hospital admissions for acute coronary syndrome declined from mid-February, 2020, falling from a 2019 baseline rate of 3017 admissions per week to 1813 per week by the end of March, 2020, a reduction of 40% (95% CI 37–43). This decline was partly reversed during April and May, 2020, such that by the last week of May, 2020, there were 2522 admissions, representing a 16% (95% CI 13–20) reduction from baseline. During the period of declining admissions, there were reductions in the numbers of admissions for all types of acute coronary syndrome, including both STEMI and NSTEMI, but relative and absolute reductions were larger for NSTEMI, with 1267 admissions per week in 2019 and 733 per week by the end of March, 2020, a percent reduction of 42% (95% CI 38–46). In parallel, reductions were recorded in the number of PCI procedures for patients with both STEMI (438 PCI procedures per week in 2019 vs 346 by the end of March, 2020; percent reduction 21%, 95% CI 12–29) and NSTEMI (383 PCI procedures per week in 2019 vs 240 by the end of March, 2020; percent reduction 37%, 29–45). The median length of stay among patients with acute coronary syndrome fell from 4 days (IQR 2–9) in 2019 to 3 days (1–5) by the end of March, 2020. INTERPRETATION: Compared with the weekly average in 2019, there was a substantial reduction in the weekly numbers of patients with acute coronary syndrome who were admitted to hospital in England by the end of March, 2020, which had been partly reversed by the end of May, 2020. The reduced number of admissions during this period is likely to have resulted in increases in out-of-hospital deaths and long-term complications of myocardial infarction and missed opportunities to offer secondary prevention treatment for patients with coronary heart disease. The full extent of the effect of COVID-19 on the management of patients with acute coronary syndrome will continue to be assessed by updating these analyses. FUNDING: UK Medical Research Council, British Heart Foundation, Public Health England, Health Data Research UK, and the National Institute for Health Research Oxford Biomedical Research Centre.
has issue date	2020-08-08(xsd:dateTime)
bibo:doi	10.1016/s0140-6736(20)31356-8
bibo:pmid	32679111
has license	cc-by
schema:url	https://doi.org/10.1016/s0140-6736%2820%2931356-8
resource representing a document's title	COVID-19 pandemic and admission rates for and management of acute coronary syndromes in England
has PubMed Central identifier	PMC7429983
has PubMed identifier	32679111
schema:publication	Lancet
resource representing a document's body	covid:PMC7429983#body_text
is schema:about of	named entity 'pandemic' named entity 'angiography' named entity 'acute coronary syndrome' named entity 'mortality rates' named entity 'International Classification of Diseases 10th revision' named entity 'STEMI' named entity 'acute coronary syndrome' named entity 'Patient Care' named entity 'acute coronary syndrome' named entity 'STEMI' named entity 'acute coronary syndrome' named entity 'coronary angiography' named entity 'COVID-19' named entity 'cardiologists' named entity 'acute coronary syndrome' named entity 'UK Government' named entity 'myocardial infarction' named entity 'PCI' named entity 'Poisson distribution' named entity 'comorbidities' named entity 'acute coronary syndrome' named entity 'acute coronary syndromes' named entity 'myocardial infarction' named entity 'COVID-19 in the UK' named entity 'COVID-19 pandemic' named entity 'reperfusion therapy' named entity 'acute coronary syndrome' named entity 'comorbidities' named entity 'acute coronary syndrome' named entity 'COVID' named entity 'STEMI' named entity 'acute coronary syndrome' named entity 'Italy' named entity 'myocardial ischaemia' named entity 'acute coronary syndromes' named entity 'unstable angina' named entity 'ICD-10' named entity 'acute coronary syndrome' named entity '95% CI' named entity 'UK lockdown' named entity 'infection' named entity 'long-term' named entity 'ICD-10' named entity 'hospital stays' named entity 'percutaneous coronary intervention' named entity 'COVID-19 pandemic' named entity 'CABG' named entity 'STEMI' named entity 'PCI' named entity 'disability' named entity 'Austria' named entity 'Secondary Uses Service' named entity 'acute coronary syndrome' named entity 'PCI' named entity 'Charlson comorbidity index' named entity 'NSTEMI' named entity 'COVID-19 pandemic' named entity 'reperfusion therapy' named entity 'STEMI' named entity 'acute coronary syndrome' named entity 'NSTEMI' named entity '95% CI' named entity 'England'

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