About: The Thrilling Journey of SARS-CoV-2 into the Intestine: From Pathogenesis to Future Clinical Implications

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	The Thrilling Journey of SARS-CoV-2 into the Intestine: From Pathogenesis to Future Clinical Implications
Creator	Cammarota, Giovanni Gasbarrini, Antonio Ianiro, Gianluca Armuzzi, Alessandro Boskoski, Ivo Costamagna, Guido Lopetuso, Loris Neri, Matteo Petito, Valentina Privitera, Giuseppe Pugliese, Daniela Ringel, Yehuda Scaldaferri, Franco Vetrone, Lorenzo
Source	Medline; PMC
abstract	Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has a direct impact on the gastrointestinal system, as up to 50% of fecal samples from coronavirus disease 2019 (COVID-19) patients contain detectable viral RNA despite a negative rhino-pharyngeal swab. This finding, together with an intestinal expression of angiotensin conversion enzyme 2 protein, suggests a possible fecal-oral transmission for SARS-CoV-2. Furthermore, gastrointestinal (GI) symptoms are common in COVID-19 patients including watery diarrhea, vomiting—particularly in children—nausea, and abdominal pain. Pathogenesis of SARS-CoV-2 infection presents significant similarities to those of some immune-mediated diseases, such as inflammatory bowel diseases or rheumatoid arthritis, leading to the hypothesis that targeted therapies used for the treatment of immune-mediated disease could be effective to treat (and possibly prevent) the main complications of COVID-19. In this review, we synthesize the present and future impact of SARS-CoV-2 infection on the gastrointestinal system and on gastroenterology practice, hypothesizing a potential role of the “gut-lung axis” and perhaps of the gut and lung microbiota into the interindividual differential susceptibility to COVID-19 19 disease. Finally, we speculate on the reorganization of outpatient gastroenterology services, which need to consider, among other factors, the major psychological impact of strict lockdown measures on the whole population.
has issue date	2020-07-28(xsd:dateTime)
bibo:doi	10.1093/ibd/izaa181
bibo:pmid	32720978
has license	no-cc
schema:url	https://doi.org/10.1093/ibd/izaa181
resource representing a document's title	The Thrilling Journey of SARS-CoV-2 into the Intestine: From Pathogenesis to Future Clinical Implications
has PubMed Central identifier	PMC7454647
has PubMed identifier	32720978
schema:publication	Inflamm Bowel Dis
resource representing a document's body	covid:PMC7454647#body_text
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