About: Cloning, expression and antiviral activity of IFNγ from the Australian fruit bat, Pteropus alecto

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About: Cloning, expression and antiviral activity of IFNγ from the Australian fruit bat, Pteropus alecto Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Cloning, expression and antiviral activity of IFNγ from the Australian fruit bat, Pteropus alecto
Creator	Wang, Lin-Fa Crameri, Gary Cowled, Chris Tachedjian, Mary Baker, Michelle Janardhana, Vijaya
Source	Elsevier; Medline; PMC
abstract	Abstract Bats are natural reservoir hosts to a variety of viruses, many of which cause morbidity and mortality in other mammals. Currently there is a paucity of information regarding the nature of the immune response to viral infections in bats, partly due to a lack of appropriate bat specific reagents. IFNγ plays a key role in controlling viral replication and coordinating a response for long term control of viral infection. Here we describe the cloning and expression of IFNγ from the Australian flying fox, Pteropus alecto and the generation of mouse monoclonal and chicken egg yolk antibodies specific to bat IFNγ. Our results demonstrate that P. alecto IFNγ is conserved with IFNγ from other species and is induced in bat splenocytes following stimulation with T cell mitogens. P. alecto IFNγ has antiviral activity on Semliki forest virus in cell lines from P. alecto and the microbat, Tadarida brasiliensis. Additionally recombinant bat IFNγ was able to mitigate Hendra virus infection in P. alecto cells. These results provide the first evidence for an antiviral role for bat IFNγ in vitro in addition to the application of important immunological reagents for further studies of bat antiviral immunity.
has issue date	2012-03-31(xsd:dateTime)
bibo:doi	10.1016/j.dci.2011.11.001
bibo:pmid	22093696
has license	els-covid
sha1sum (hex)	a02f74f8fc95c02eb346f896c5760139ec7c918a
schema:url	https://doi.org/10.1016/j.dci.2011.11.001
resource representing a document's title	Cloning, expression and antiviral activity of IFNγ from the Australian fruit bat, Pteropus alecto
has PubMed Central identifier	PMC7103211
has PubMed identifier	22093696
schema:publication	Developmental & Comparative Immunology
resource representing a document's body	covid:a02f74f8fc95c02eb346f896c5760139ec7c918a#body_text
is schema:about of	named entity 'mitogens' named entity 'describe' named entity 'P. alecto' named entity 'fruit' named entity 'ANTIVIRAL ACTIVITY' named entity 'RESPONSE' named entity 'INDUCED' named entity 'MITIGATE' named entity 'MAMMALS' named entity 'THESE' named entity 'ROLE' named entity 'EVIDENCE FOR' named entity 'BATS' named entity 'CELLS' named entity 'STIMULATION' named entity 'INFORMATION' named entity 'RECOMBINANT' named entity 'DUE TO' named entity 'IMMUNE RESPONSE' named entity 'VARIETY' named entity 'RESULTS' covid:arg/a02f74f8fc95c02eb346f896c5760139ec7c918a named entity 'BAT' named entity 'CLONING' named entity 'PTEROPUS ALECTO' named entity 'CLONING' named entity 'ANTIVIRAL' named entity 'VIRUSES' named entity 'KEY' named entity 'T CELL' named entity 'IMPORTANT' named entity 'EXPRESSION' named entity 'AUSTRALIAN' named entity 'FRUIT' named entity 'ADDITION' named entity 'PROVIDE' named entity 'MONOCLONAL' named entity 'COORDINATING' named entity 'NATURE' named entity 'VIRAL REPLICATION' named entity 'RESPONSE TO' named entity 'NATURAL' named entity 'IS A' named entity 'ANTIVIRAL ACTIVITY' named entity 'IMMUNOLOGICAL' named entity 'TADARIDA BRASILIENSIS' named entity 'PTEROPUS ALECTO' named entity 'GENERATION' named entity 'HOSTS' named entity 'CONSERVED' named entity 'IN VITRO' named entity 'SPLENOCYTES' named entity 'CONTROL' named entity 'LONG TERM' named entity 'VIRAL INFECTION' named entity 'HENDRA VIRUS INFECTION' named entity 'CURRENTLY' named entity 'REAGENTS' named entity 'SPECIES' named entity 'SEMLIKI FOREST VIRUS' named entity 'CHICKEN EGG' named entity 'IMMUNITY' named entity 'CONTROLLING' named entity 'BAT' named entity 'ANTIBODIES SPECIFIC' named entity 'AUSTRALIAN' named entity 'RESERVOIR' named entity 'LACK' named entity 'EGG YOLK' named entity 'MITOGENS' named entity 'SPECIFIC' named entity 'EXPRESSION' named entity 'HERE' named entity 'PLAYS' named entity 'APPROPRIATE' named entity 'CELL LINES'

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