About: Structure(s), function(s), and inhibition of the RNA-dependent RNA polymerase of noroviruses

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About: Structure(s), function(s), and inhibition of the RNA-dependent RNA polymerase of noroviruses Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Structure(s), function(s), and inhibition of the RNA-dependent RNA polymerase of noroviruses
Creator	Chuang, Ying-Chih Deval, Jerome Jin, Zhinan Cheng Kao, C
Source	Elsevier; Medline; PMC
abstract	Abstract Noroviruses belong to the Caliciviridae family of single-stranded positive-sense RNA viruses. The genus Norovirus includes seven genogroups (designated GI-GVII), of which GI, GII and GIV infect humans. Human noroviruses are responsible for widespread outbreaks of acute gastroenteritis and represent one of the most common causes of foodborne illness. No vaccine or antiviral treatment options are available for norovirus infection. The RNA-dependent RNA polymerase (RdRp) of noroviruses is a key enzyme responsible for transcription and replication of the viral genome. Here, we review the progress made in understanding the structures and functions of norovirus RdRp and its use as a target for small molecule inhibitors. Crystal structures of the RdRp at different stages of substrate interaction have been determined, which shed light on its multi-step catalytic cycle. The in vitro assays and in vivo animal models that have been developed to identify and characterize inhibitors of norovirus RdRp are also summarized, followed by an update on the current antiviral research targeting different regions of norovirus RdRp. In the future, structure-based drug design and rational optimization of known nucleoside and non-nucleoside inhibitors of norovirus RdRp may pave the way towards the next generation of direct-acting antivirals.
has issue date	2017-04-15(xsd:dateTime)
bibo:doi	10.1016/j.virusres.2016.12.018
bibo:pmid	28041960
has license	els-covid
sha1sum (hex)	a0415950b81ee8e59f7dfb0d9fdab09c9242c71b
schema:url	https://doi.org/10.1016/j.virusres.2016.12.018
resource representing a document's title	Structure(s), function(s), and inhibition of the RNA-dependent RNA polymerase of noroviruses
has PubMed Central identifier	PMC7114559
has PubMed identifier	28041960
schema:publication	Virus Research
resource representing a document's body	covid:a0415950b81ee8e59f7dfb0d9fdab09c9242c71b#body_text
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