About: Crystal structure of Nsp15 endoribonuclease NendoU from SARS‐CoV‐2

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About: Crystal structure of Nsp15 endoribonuclease NendoU from SARS‐CoV‐2 Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Crystal structure of Nsp15 endoribonuclease NendoU from SARS‐CoV‐2
Creator	Joachimiak, Andrzej Michalska, Karolina Endres, Michael Jedrzejczak, Robert Kim, Youngchang Maltseva, Natalia Wilamowski, Mateusz Godzik, \|
Source	Medline; PMC
abstract	Severe Acute Respiratory Syndrome coronavirus 2 (SARS‐CoV‐2) is rapidly spreading around the world. There is no existing vaccine or proven drug to prevent infections and stop virus proliferation. Although this virus is similar to human and animal SARS‐CoVs and Middle East Respiratory Syndrome coronavirus (MERS‐CoVs), the detailed information about SARS‐CoV‐2 proteins structures and functions is urgently needed to rapidly develop effective vaccines, antibodies, and antivirals. We applied high‐throughput protein production and structure determination pipeline at the Center for Structural Genomics of Infectious Diseases to produce SARS‐CoV‐2 proteins and structures. Here we report two high‐resolution crystal structures of endoribonuclease Nsp15/NendoU. We compare these structures with previously reported homologs from SARS and MERS coronaviruses.
has issue date	2020-05-02(xsd:dateTime)
bibo:doi	10.1002/pro.3873
bibo:pmid	32304108
has license	cc-by-nc-nd
sha1sum (hex)	a05f5b57aba64c87638f179c0c16923cba7a99ac
schema:url	https://doi.org/10.1002/pro.3873
resource representing a document's title	Crystal structure of Nsp15 endoribonuclease NendoU from SARS‐CoV‐2
has PubMed Central identifier	PMC7264519
has PubMed identifier	32304108
schema:publication	Protein Sci
resource representing a document's body	covid:a05f5b57aba64c87638f179c0c16923cba7a99ac#body_text
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