About: Viral protein R of human immunodeficiency virus type-1 induces retrotransposition of long interspersed element-1

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About: Viral protein R of human immunodeficiency virus type-1 induces retrotransposition of long interspersed element-1 Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Viral protein R of human immunodeficiency virus type-1 induces retrotransposition of long interspersed element-1
Creator	Baba, Masanori Dohi, Taeko Doi, Akihiro Gatanaga, Hiroyuki Goto, Motohito Hagiwara, Shotaro Hoshino, Shigeki Iguchi, Taku Iijima, Kenta Ishizaka, Yukihito Kano, Shigeyuki Matsunaga, Akihiro Oka, Shinichi Okamura, Tadashi Okudaira, Noriyuki Otsubo, Takeshi Saito, Yoshikazu Shimura, Mari Tamura, Masato Tanuma, Junko Yanagita, Motoko Kawamura, Yuki
Source	Medline; PMC
abstract	BACKGROUND: Viral protein R (Vpr), a protein of human immunodeficiency virus type-1 (HIV-1) with various biological functions, was shown to be present in the blood of HIV-1-positive patients. However, it remained unclear whether circulating Vpr in patients’ blood is biologically active. Here, we examined the activity of blood Vpr using an assay system by which retrotransposition of long interspersed element-1 (L1-RTP) was detected. We also investigated the in vivo effects of recombinant Vpr (rVpr) by administrating it to transgenic mice harboring human L1 as a transgene (hL1-Tg mice). Based on our data, we discuss the involvement of blood Vpr in the clinical symptoms of acquired immunodeficiency syndrome (AIDS). RESULTS: We first discovered that rVpr was active in induction of L1-RTP. Biochemical analyses revealed that rVpr-induced L1-RTP depended on the aryl hydrocarbon receptor, mitogen-activated protein kinases, and CCAAT/enhancer-binding protein β. By using a sensitive L1-RTP assay system, we showed that 6 of the 15 blood samples from HIV-1 patients examined were positive for induction of L1-RTP. Of note, the L1-RTP-inducing activity was blocked by a monoclonal antibody specific for Vpr. Moreover, L1-RTP was reproducibly induced in various organs, including the kidney, when rVpr was administered to hL1-Tg mice. CONCLUSIONS: Blood Vpr is biologically active, suggesting that its monitoring is worthwhile for clarification of the roles of Vpr in the pathogenesis of AIDS. This is the first report to demonstrate a soluble factor in patients’ blood active for L1-RTP activity, and implies the involvement of L1-RTP in the development of human diseases.
has issue date	2013-08-05(xsd:dateTime)
bibo:doi	10.1186/1742-4690-10-83
bibo:pmid	23915234
has license	cc-by
sha1sum (hex)	a09a978336b5c98928dbfb37b12da84d327bfe2d
schema:url	https://doi.org/10.1186/1742-4690-10-83
resource representing a document's title	Viral protein R of human immunodeficiency virus type-1 induces retrotransposition of long interspersed element-1
has PubMed Central identifier	PMC3751050
has PubMed identifier	23915234
schema:publication	Retrovirology
resource representing a document's body	covid:a09a978336b5c98928dbfb37b12da84d327bfe2d#body_text
is schema:about of	named entity 'RETROTRANSPOSITION' named entity 'blood' named entity 'retrotransposition' named entity 'acquired immunodeficiency syndrome' named entity 'HIV-1' named entity 'long' named entity 'VIRAL PROTEIN R' named entity 'POSITIVE' named entity 'PROTEIN ' named entity 'BLOOD' named entity 'VARIOUS' named entity 'ACTIVITY' named entity 'OUR' named entity 'VPR' named entity 'RTP' named entity 'HUMAN' named entity 'ASSAY' named entity 'DATA' named entity 'INVESTIGATED' named entity 'EXAMINED' named entity 'RECOMBINANT' named entity 'HIV-1' named entity 'LONG INTERSPERSED ELEMENT' named entity 'UNCLEAR' named entity 'IN VIVO' named entity 'TRANSGENE' named entity 'LONG INTERSPERSED ELEMENT' named entity 'HERE' named entity 'DISCUSS' named entity 'MICE' named entity 'BIOLOGICALLY' covid:arg/a09a978336b5c98928dbfb37b12da84d327bfe2d named entity 'A PROTEIN' named entity 'PRESENT' named entity 'DETECTED' named entity 'HUMAN IMMUNODEFICIENCY VIRUS' named entity 'VIRUS TYPE' named entity 'VIRAL PROTEIN R' named entity 'CLINICAL SYMPTOMS' named entity 'ACTIVE' named entity 'ACQUIRED IMMUNODEFICIENCY SYNDROME' named entity 'USING' named entity 'BACKGROUND' named entity 'EFFECTS' named entity 'CIRCULATING' named entity 'BIOLOGICAL FUNCTIONS' named entity 'PATIENTS' named entity 'VIRUS TYPE' named entity 'TRANSGENIC MICE' named entity 'RETROTRANSPOSITION' named entity 'HARBORING' named entity 'BASED' named entity 'INVOLVEMENT' named entity 'HUMAN IMMUNODEFICIENCY VIRUS' named entity 'SYSTEM' named entity 'RTP' named entity 'activity' named entity 'blood' named entity 'AIDS' named entity 'Viral protein'

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