About: Therapeutic potential of coumarins as antiviral agents

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Therapeutic potential of coumarins as antiviral agents
Creator	Osman, Hasnah Ali, Mohamed Ahsan, Mohamed Hassan, Mohd
Source	Elsevier; Medline; PMC
abstract	Abstract Coumarins have received a considerable attention in the last three decades as a lead structures for the discovery of orally bioavailable non-peptidic antiviral agents. A lot of structurally diverse coumarins analogues were found to display remarkable array of affinity with the different molecular targets for antiviral agents and slight modifications around the central motif result in pronounced changes in its antiviral spectrum. This manuscript thoroughly reviews the design, discovery and structure–activity relationship studies of the coumarin analogues as antiviral agents focusing mainly on lead optimization and its development into clinical candidates.
has issue date	2016-11-10(xsd:dateTime)
bibo:doi	10.1016/j.ejmech.2016.07.056
bibo:pmid	27484512
has license	els-covid
sha1sum (hex)	a0a5fe6805a6a370e31628c78c5803eeb38093f9
schema:url	https://doi.org/10.1016/j.ejmech.2016.07.056
resource representing a document's title	Therapeutic potential of coumarins as antiviral agents
has PubMed Central identifier	PMC7115672
has PubMed identifier	27484512
schema:publication	European Journal of Medicinal Chemistry
resource representing a document's body	covid:a0a5fe6805a6a370e31628c78c5803eeb38093f9#body_text
is schema:about of	named entity 'antiviral agents' named entity 'studies' named entity 'discovery' named entity 'antiviral' named entity 'affinity' named entity 'THERAPEUTIC' named entity 'ATTENTION' named entity 'COUMARIN' named entity 'RELATIONSHIP' named entity 'DISCOVERY' named entity 'POTENTIAL' named entity 'HAVE' named entity 'MOLECULAR' named entity 'DIVERSE' named entity 'CHANGES' named entity 'CENTRAL' named entity 'COUMARINS' named entity 'ANTIVIRAL AGENTS' named entity 'REVIEWS' named entity 'DEVELOPMENT' named entity 'ANTIVIRAL AGENTS' named entity 'TARGETS' named entity 'TO DISPLAY' named entity 'RESULT' named entity 'SLIGHT' named entity 'BIOAVAILABLE' named entity 'LEAD' named entity 'FOCUSING' named entity 'MOTIF' named entity 'COUMARINS' named entity 'CLINICAL' named entity 'MANUSCRIPT' named entity 'ANTIVIRAL' named entity 'THOROUGHLY' named entity 'AFFINITY' named entity 'RECEIVED' named entity 'ITS' named entity 'NON-' named entity 'SPECTRUM' named entity 'ARRAY' named entity 'STUDIES' named entity 'DESIGN' named entity 'LEAD OPTIMIZATION' named entity 'DIFFERENT' named entity 'FOUND' named entity 'ORALLY' named entity 'CONSIDERABLE' named entity 'STRUCTURES' named entity 'analogues' named entity 'coumarin' named entity 'antiviral agents' named entity 'coumarins' named entity 'antiviral agents' named entity 'antiviral agents' named entity 'orally' named entity 'antiviral agents' named entity 'resistant strains' named entity 'multi-target' named entity 'antiviral drugs' named entity 'potency' named entity 'pyrone' named entity 'anti-HIV' named entity 'RSV' named entity 'virion' named entity 'coumarins' named entity 'SARS' named entity 'sesquiterpene' named entity 'herpes virus' named entity 'Oral bioavailability' named entity 'warfarin' named entity 'viruses' named entity 'CHIKV' named entity 'Cell culture assay' named entity 'public health' named entity 'HIV' named entity 'adverse effects' named entity 'SAR' named entity 'synergistic'

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