About: Efficacy of a live attenuated vaccine in classical swine fever virus postnatally persistently infected pigs

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Efficacy of a live attenuated vaccine in classical swine fever virus postnatally persistently infected pigs
Creator	Summerfield, Artur Domingo, Mariano Ganges, Llilianne Muñoz, Marta Muñoz-González, Sara Perez-Simó, Marta Rosell, Rosa Ruggli, Nicolas Alejandro Bohorquez, José
Source	Medline; PMC
abstract	Classical swine fever (CSF) causes major losses in pig farming, with various degrees of disease severity. Efficient live attenuated vaccines against classical swine fever virus (CSFV) are used routinely in endemic countries. However, despite intensive vaccination programs in these areas for more than 20 years, CSF has not been eradicated. Molecular epidemiology studies in these regions suggests that the virus circulating in the field has evolved under the positive selection pressure exerted by the immune response to the vaccine, leading to new attenuated viral variants. Recent work by our group demonstrated that a high proportion of persistently infected piglets can be generated by early postnatal infection with low and moderately virulent CSFV strains. Here, we studied the immune response to a hog cholera lapinised virus vaccine (HCLV), C-strain, in six-week-old persistently infected pigs following post-natal infection. CSFV-negative pigs were vaccinated as controls. The humoral and interferon gamma responses as well as the CSFV RNA loads were monitored for 21 days post-vaccination. No vaccine viral RNA was detected in the serum samples and tonsils from CSFV postnatally persistently infected pigs for 21 days post-vaccination. Furthermore, no E2-specific antibody response or neutralising antibody titres were shown in CSFV persistently infected vaccinated animals. Likewise, no of IFN-gamma producing cell response against CSFV or PHA was observed. To our knowledge, this is the first report demonstrating the absence of a response to vaccination in CSFV persistently infected pigs.
has issue date	2015-07-09(xsd:dateTime)
bibo:doi	10.1186/s13567-015-0209-9
bibo:pmid	26159607
has license	cc-by
sha1sum (hex)	a0b13baa35ff28471952e5011f9411529d217f50
schema:url	https://doi.org/10.1186/s13567-015-0209-9
resource representing a document's title	Efficacy of a live attenuated vaccine in classical swine fever virus postnatally persistently infected pigs
has PubMed Central identifier	PMC4496848
has PubMed identifier	26159607
schema:publication	Vet Res
resource representing a document's body	covid:a0b13baa35ff28471952e5011f9411529d217f50#body_text
is schema:about of	named entity 'LIVE ATTENUATED VACCINE' named entity 'INFECTED' named entity 'PERSISTENTLY' named entity 'response' named entity 'samples' named entity 'demonstrating' named entity 'RNA' named entity 'swine fever' named entity 'farming' named entity 'live attenuated' named entity 'swine fever' named entity 'EFFICACY' named entity 'INFECTED' named entity 'SERUM' named entity 'MONITORED' named entity 'EXERTED' named entity 'SAMPLES' named entity 'STRAIN' named entity 'OUR' named entity 'VIRULENT' named entity 'ANTIBODY RESPONSE' named entity 'PERSISTENTLY' named entity 'CIRCULATING' named entity 'GROUP' named entity 'RECENT' named entity 'MORE THAN' named entity 'DAYS' named entity 'COUNTRIES' named entity 'OBSERVED' named entity 'VIRUS VACCINE' named entity 'RNA' named entity 'PRODUCING' named entity 'FOLLOWING' named entity 'INTERFERON GAMMA ' named entity 'EFFICIENT' named entity 'NEGATIVE' named entity 'VACCINE' named entity 'MAJOR' named entity 'TONSILS' named entity 'KNOWLEDGE' named entity 'VACCINATED' named entity 'NEW' named entity 'PIG' named entity 'DEGREES' named entity 'VIRUS' named entity 'AREAS' named entity 'INFECTION' named entity 'STRAINS' named entity 'CAUSES' named entity 'CLASSICAL SWINE FEVER VIRUS' named entity 'ENDEMIC' named entity 'PIGS' named entity 'LOW' named entity 'POSITIVE SELECTION' named entity 'DISEASE SEVERITY' named entity 'LEADING' named entity 'VARIANTS' named entity 'POST' named entity 'ANTIBODY TITRES' named entity 'ATTENUATED' named entity 'DEMONSTRATED' named entity 'CSF' named entity 'IMMUNE RESPONSE' named entity 'VIRAL' named entity 'IFN-GAMMA' covid:arg/a0b13baa35ff28471952e5011f9411529d217f50 named entity 'THESE' named entity 'CLASSICAL SWINE FEVER VIRUS' named entity 'SELECTION PRESSURE' named entity 'RESPONSES' named entity 'PIGS' named entity 'OLD' named entity 'VACCINATION'

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