About: Unequivocal glycyrrhizin isomer determination and comparative in vitro bioactivities of root extracts in four Glycyrrhiza species

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About: Unequivocal glycyrrhizin isomer determination and comparative in vitro bioactivities of root extracts in four Glycyrrhiza species Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Unequivocal glycyrrhizin isomer determination and comparative in vitro bioactivities of root extracts in four Glycyrrhiza species
Creator	Porzel, Andrea Farag, Mohamed Wessjohann, Ludger
Source	PMC
abstract	Glycyrrhiza glabra, commonly known as licorice, is a popular herbal supplement used for the treatment of chronic inflammatory conditions and as sweetener in the food industry. This species contains a myriad of phytochemicals including the major saponin glycoside glycyrrhizin (G) of Glycyrrhetinic acid (GA) aglycone. In this study, 2D-ROESY NMR technique was successfully applied for distinguishing 18α and 18β glycyrrhetinic acid (GA). ROESY spectra acquired from G. glabra, Glycyrrhiza uralensis and Glycyrrhiza inflata crude extracts revealed the presence of G in its β-form. Anti-inflammatory activity of four Glycyrrhiza species, G, glabra, G. uralensis, G. inflata, and G. echinata roots was assessed against COX-1 inhibition revealing that phenolics rather than glycyrrhizin are biologically active in this assay. G. inflata exhibits a strong cytotoxic effect against PC3 and HT29 cells lines, whereas other species are inactive. This study presents an effective NMR method for G isomer assignment in licorice extracts that does not require any preliminary chromatography or any other purification step.
has issue date	2014-05-14(xsd:dateTime)
bibo:doi	10.1016/j.jare.2014.05.001
bibo:pmid	25685548
has license	cc-by-nc-nd
sha1sum (hex)	a0b5cb01c765429c9f82a74d5822f2cd6ec5dcaa
schema:url	https://doi.org/10.1016/j.jare.2014.05.001
resource representing a document's title	Unequivocal glycyrrhizin isomer determination and comparative in vitro bioactivities of root extracts in four Glycyrrhiza species
has PubMed Central identifier	PMC4293670
has PubMed identifier	25685548
schema:publication	J Adv Res
resource representing a document's body	covid:a0b5cb01c765429c9f82a74d5822f2cd6ec5dcaa#body_text
is schema:about of	named entity 'UNEQUIVOCAL' named entity 'glycyrrhizin' named entity 'extracts' named entity 'ROOT' named entity 'EXTRACTS' named entity 'ISOMER' named entity 'GLYCYRRHIZIN' named entity 'DETERMINATION' named entity 'SPECIES' named entity 'GLYCYRRHIZA' named entity 'IN VITRO' named entity 'isomer' named entity 'species' named entity 'cell lines' named entity 'Asia' named entity 'nitrogen' named entity 'isoliquiritigenin' named entity 'LOX' named entity 'DMSO' named entity 'Glycyrrhizin' named entity 'cytotoxic' named entity '37°C' named entity 'epimers' named entity 'cytotoxic' named entity 'epimers' named entity 'Glycyrrhizin' named entity 'solvent' named entity 'anti-inflammatory' named entity 'NMR' named entity 'synergistically' named entity 'Anti-inflammatory' named entity 'prostate' named entity 'HSQC' named entity 'significant difference' named entity 'Glycyrrhizin' named entity 'G. inflata' named entity 'Prof.' named entity '11,000' named entity 'anti-inflammatory effect' named entity 'Methanol' named entity 'resin' named entity 'prostate' named entity 'liquorice' named entity 'antibiotic' named entity 'PC3' named entity 'flavonoids' named entity 'methoxy' named entity 'phenolics' named entity 'wavelength' named entity 'chiral' named entity 'glycyrrhetinic acid' named entity 'G. inflata' named entity 'isomers' named entity 'evaporation' named entity 'proton' named entity 'Glycyrrhizin' named entity 'saponins' named entity 'room temperature' named entity 'plant extracts' named entity 'HPTLC' named entity 'Licorice' named entity 'Glycyrrhiza' named entity 'MS.' named entity 'licorice' named entity 'NMR' named entity 'NMR' named entity 'scientific evidence' named entity 'colon cancer' named entity 'flavonoids' named entity 'pharmacological' named entity 'metabolite' named entity 'Glycyrrhizin' named entity 'cytotoxicity' named entity 'methanol' named entity 'centrifugation' named entity 'nitro' named entity 'antiulcer' named entity 'protons' named entity 'fetal bovine serum'

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