About: Discovery of a novel swine enteric alphacoronavirus (SeACoV) in southern China

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: Discovery of a novel swine enteric alphacoronavirus (SeACoV) in southern China Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Discovery of a novel swine enteric alphacoronavirus (SeACoV) in southern China
Creator	Wang, Bin Song, Yanhua Huang, Yao-Wei Qin, Pan Yang, Yong-Le Zhao, Pengwei Pan, Yongfei Tian, Xiaoyan Wang, Dongdong Wang, Lianxiang Zhang, Xiangbin
source	Elsevier; Medline; PMC
abstract	Outbreaks of diarrhea in newborn piglets without detection of transmissible gastroenteritis virus (TGEV), porcine epidemic diarrhea virus (PEDV) and porcine deltacoronavirus (PDCoV), have been recorded in a pig farm in southern China since February 2017. Isolation and propagation of the pathogen in cell culture resulted in discovery of a novel swine enteric alphacoronavirus (tentatively named SeACoV) related to the bat coronavirus HKU2 identified in the same region a decade ago. Specific fluorescence signal was detected in Vero cells infected with SeACoV by using a positive sow serum collected in the same farm, but not by using TGEV-, PEDV- or PDCoV-specific antibody. Electron microscopy observation demonstrated that the virus particle with surface projections was 100–120 nm in diameter. Complete genomic sequencing and analyses of SeACoV indicated that the extreme amino-terminal domain of the SeACoV spike (S) glycoprotein structurally similar to the domain 0 of the alphacoronavirus NL63, whereas the rest part of S structurally resembles domains B to D of the betacoronavirus. The SeACoV-S domain 0 associated with enteric tropism had an extremely high variability, harboring 75-amino-acid (aa) substitutions and a 2-aa insertion, compared to that of HKU2, which is likely responsible for the extended host range or cross-species transmission. The isolated virus was infectious in pigs when inoculated orally into 3-day-old newborn piglets, leading to clinical signs of diarrhea and fecal virus shedding. These results confirmed that it is a novel swine enteric coronavirus representing the fifth porcine coronavirus.
has issue date	2017-09-28(xsd:dateTime)
bibo:doi	10.1016/j.vetmic.2017.09.020
bibo:pmid	29102111
has license	no-cc
sha1sum (hex)	a0b93413291741edef6702805b014946e257e333
schema:url	https://doi.org/10.1016/j.vetmic.2017.09.020
resource representing a document's title	Discovery of a novel swine enteric alphacoronavirus (SeACoV) in southern China
has PubMed Central identifier	PMC7117260
has PubMed identifier	29102111
schema:publication	Vet Microbiol
resource representing a document's body	covid:a0b93413291741edef6702805b014946e257e333#body_text
is schema:about of	named entity 'virus' named entity 'fluorescence' named entity 'diameter' named entity 'positive' named entity 'enteric' named entity 'CLINICAL SIGNS ' covid:arg/a0b93413291741edef6702805b014946e257e333 named entity 'DIARRHEA' named entity 'DAY-OLD' named entity 'SERUM' named entity 'DISCOVERY' named entity 'NOVEL' named entity 'SOW' named entity 'VIRUS SHEDDING' named entity 'INSERTION' named entity 'IS A' named entity 'PIG FARM' named entity 'FLUORESCENCE' named entity 'ALPHACORONAVIRUS' named entity 'DIAMETER' named entity 'SIGNAL' named entity 'PORCINE DELTACORONAVIRUS' named entity 'CONFIRMED' named entity 'USING' named entity 'REGION A' named entity 'POSITIVE' named entity 'CELL CULTURE' named entity 'DETECTED' named entity 'OUTBREAKS' named entity 'PIGS' named entity '120' named entity 'INDICATED' named entity 'HARBORING' named entity 'SPECIFIC ANTIBODY' named entity 'TROPISM' named entity 'TRANSMISSIBLE GASTROENTERITIS VIRUS' named entity 'ELECTRON MICROSCOPY' named entity 'TRANSMISSION' named entity 'SWINE ENTERIC CORONAVIRUS' named entity 'AMINO' named entity 'FEBRUARY' named entity 'GENOMIC SEQUENCING' named entity 'THESE' named entity 'EXTREME' named entity 'OBSERVATION' named entity 'COLLECTED' named entity 'IDENTIFIED' named entity 'PART OF' named entity 'NL63' named entity 'SWINE ENTERIC ALPHACORONAVIRUS' named entity 'SOUTHERN' named entity 'CHINA' named entity 'HIGH VARIABILITY' named entity 'LIKELY' named entity 'TERMINAL' named entity 'COMPLETE' named entity 'HAVE' named entity 'DETECTION' named entity 'GLYCOPROTEIN' named entity 'FARM' named entity 'RESPONSIBLE' named entity 'AMINO-ACID' named entity 'NOVEL' named entity 'SPIKE' named entity 'RELATED' named entity 'CORONAVIRUS' named entity 'DECADE' named entity '100' named entity 'REST' named entity 'SPECIES' named entity 'BUT'

Faceted Search & Find service v1.13.91 as of Mar 24 2020

Alternative Linked Data Documents: Sponger | ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3229 as of Jul 10 2020, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (94 GB total memory)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2025 OpenLink Software