About: The protein expression profile of ACE2 in human tissues

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	The protein expression profile of ACE2 in human tissues
Creator	Hikmet, Feria Lindskog, Cecilia Méar, Loren Uhlén, Mathias Edvinsson, Åsa Micke, Patrick
Source	Medline; PMC
abstract	The novel SARS‐coronavirus 2 (SARS‐CoV‐2) poses a global challenge on healthcare and society. For understanding the susceptibility for SARS‐CoV‐2 infection, the cell type‐specific expression of the host cell surface receptor is necessary. The key protein suggested to be involved in host cell entry is angiotensin I converting enzyme 2 (ACE2). Here, we report the expression pattern of ACE2 across > 150 different cell types corresponding to all major human tissues and organs based on stringent immunohistochemical analysis. The results were compared with several datasets both on the mRNA and protein level. ACE2 expression was mainly observed in enterocytes, renal tubules, gallbladder, cardiomyocytes, male reproductive cells, placental trophoblasts, ductal cells, eye, and vasculature. In the respiratory system, the expression was limited, with no or only low expression in a subset of cells in a few individuals, observed by one antibody only. Our data constitute an important resource for further studies on SARS‐CoV‐2 host cell entry, in order to understand the biology of the disease and to aid in the development of effective treatments to the viral infection.
has issue date	2020-07-26(xsd:dateTime)
bibo:doi	10.15252/msb.20209610
bibo:pmid	32715618
has license	cc-by
sha1sum (hex)	a0da1114f712a79b19ed2bef8ee527a75fbfecf6
schema:url	https://doi.org/10.15252/msb.20209610
resource representing a document's title	The protein expression profile of ACE2 in human tissues
has PubMed Central identifier	PMC7383091
has PubMed identifier	32715618
schema:publication	Mol Syst Biol
resource representing a document's body	covid:a0da1114f712a79b19ed2bef8ee527a75fbfecf6#body_text
is schema:about of	named entity 'protein' named entity 'placental' named entity 'expression' named entity 'cell' named entity 'protein' named entity 'ACROSS' named entity 'RENAL TUBULES' named entity 'UNDERSTANDING' named entity 'CELLS' named entity 'EXPRESSION' named entity 'PROTEIN LEVEL' named entity 'EXPRESSION PATTERN' named entity 'MALE' named entity '150' named entity 'REPORT' named entity 'HOST CELL' named entity 'CARDIOMYOCYTES' named entity 'DIFFERENT' named entity 'cell types' named entity 'human tissues' named entity 'Our' named entity 'order' named entity 'viral infection' named entity 'respiratory system' named entity 'gallbladder' named entity 'individuals' named entity 'healthcare' named entity 'global challenge' named entity 'poses' named entity 'limited' named entity 'observed' named entity 'SARS-CoV-2' named entity 'cell surface receptor' named entity 'ACE2' named entity 'placental' named entity 'infection' named entity 'coronavirus 2' named entity 'cell entry' named entity 'renal tubules' named entity 'ACE2' named entity 'human tissues' named entity 'converting' named entity 'peritubular' named entity 'ciliated cells' named entity 'individual variation' named entity 'epididymis' named entity 'staining' named entity 'Protein expression' named entity 'tissue samples' named entity 'cell types' named entity 'respiratory tract' named entity 'ACE2' named entity 'pathologist' named entity 'protein' named entity 'Merck Millipore' named entity 'proteases' named entity 'intestinal tract' named entity 'chemiluminescence' named entity 'Human tissues' named entity 'testis' named entity 'kidney' named entity 'Primary antibodies' named entity 'human tissue' named entity 'placental' named entity 'Leydig cells' named entity 'hyperinflammation' named entity 'ACE2' named entity 'nasal mucosa' named entity 'immunohistochemical' named entity 'lung parenchyma' named entity 'ACE2' named entity 'adipose tissue' named entity 'ACE2' named entity 'upregulation' named entity 'nasal mucosa' named entity 'MERS-CoV'

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