About: Olfactory Dysfunction and Sinonasal Symptomatology in COVID-19: Prevalence, Severity, Timing, and Associated Characteristics

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About: Olfactory Dysfunction and Sinonasal Symptomatology in COVID-19: Prevalence, Severity, Timing, and Associated Characteristics Goto Sponge NotDistinct Permalink

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Olfactory Dysfunction and Sinonasal Symptomatology in COVID-19: Prevalence, Severity, Timing, and Associated Characteristics
Creator	Brockmeier, Steffi Gengler, Isabelle Obere, Michael Sedaghat, Ahmad Singer-Cornelius, Thirza Speth, Marlene
source	Medline; PMC
abstract	OBJECTIVE: Olfactory dysfunction (OD)—hyposmia or anosmia—is a symptom of coronavirus disease 2019 (COVID-19), caused by the novel coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). We sought to better determine prevalence, severity, and timing of OD in COVID-19 relative to other sinonasal and pulmonary symptoms. STUDY DESIGN: Prospective, cross-sectional. SETTING: Regional/cantonal hospital. SUBJECTS: In total, 103 patients diagnosed with COVID-19 with reverse transcription polymerase chain reaction (RT-PCR)–based testing. METHODS: All patients testing positive for COVID-19 at Kantonsspital Aarau over a 6-week period were approached. Timing and severity (at its worst, on scale of 0 [none], 1 [mild], 2 [moderate], and 3 [severe]) of OD, loss of taste, nasal obstruction, rhinorrhea/mucus production, fever, cough and shortness of breath (SOB) were assessed for each patient. RESULTS: Prevalence of OD was 61.2%, and severity of OD was strongly correlated with severity of loss of taste experienced (ρ = 0.87, P < .001). OD was experienced on the first day of COVID-19 by 8.7% and overall occurred at median infection day 3 (mean, 3.4; range, 0-12). Most experiencing OD reported anosmia, and mean severity of all with OD was moderate to severe (mean [SD], 2.7 [0.6]). Nasal obstruction (49.5%) and rhinorrhea (35.0%) were frequently reported but not correlated with OD. SOB was more severe in patients with OD. OD was associated negatively with older age (OR, 0.96; 95% CI, 0.93-0.99; P = .007) and positively with female sex (OR, 2.46; 95% CI, 0.98-6.19; P = .056). CONCLUSIONS: OD is highly prevalent during COVID-19, occurring early and severely, often in conjunction with loss of taste. OD is associated negatively with older age and positively with female sex. Patients with OD may also experience more severe SOB.
has issue date	2020-05-19(xsd:dateTime)
bibo:doi	10.1177/0194599820929185
bibo:pmid	32423357
has license	cc-by
sha1sum (hex)	a10c52067f7d33d0fc1a85e513d6c1a8f0cbb2b5
schema:url	https://doi.org/10.1177/0194599820929185
resource representing a document's title	Olfactory Dysfunction and Sinonasal Symptomatology in COVID-19: Prevalence, Severity, Timing, and Associated Characteristics
has PubMed Central identifier	PMC7240313
has PubMed identifier	32423357
schema:publication	Otolaryngol Head Neck Surg
resource representing a document's body	covid:a10c52067f7d33d0fc1a85e513d6c1a8f0cbb2b5#body_text
is schema:about of	named entity 'coronavirus disease 2019' named entity 'SARS-CoV-2' named entity 'fever' named entity 'COVID-19' named entity 'sense of taste' named entity 'coronavirus' named entity 'intensive care units' named entity 'COVID-19' named entity 'shortness of breath' named entity 'Switzerland' named entity '95% CI' named entity 'older age' named entity 'American Academy of Otolaryngology' named entity 'shortness of breath' named entity 'SOB' named entity 'animal models' named entity 'cough' named entity 'COVID-19' named entity 'runny nose' named entity 'pathognomonic' named entity 'hyposmia' named entity 'sense of taste' named entity 'COVID-19' named entity 'sense of smell' named entity 'SARS-CoV-2' named entity 'shortness of breath' named entity 'airway' named entity 'infection' named entity 'COVID-19' named entity 'shortness of breath' named entity '95% CI' named entity 'rhinorrhea' named entity 'COVID' named entity 'COVID' named entity 'COVID-19' named entity 'asymptomatic carriers' named entity 'COVID' named entity 'institutional review board' named entity 'COVID-19' named entity 'COVID' named entity 'RT-PCR' named entity 'cough' named entity '95% CI' named entity 'nasal cavity' named entity 'cough' named entity 'nasal mucus' named entity 'descriptive statistics' named entity 'viral replication' named entity 'COVID' named entity 'loss of smell' named entity 'Logistic regression' named entity 'fever' named entity 'anosmia' named entity 'nasal obstruction' named entity 'China' named entity 'cough' named entity 'COVID' named entity 'symptom' named entity 'nasal obstruction' named entity '95% CI' named entity 'nasal cavity' named entity 'cough' named entity 'March 3, 2020' named entity 'rhinorrhea' named entity 'anosmia' named entity 'hyposmia' named entity 'cough' named entity '95% CI' named entity 'fever' named entity 'loss of taste' named entity 'olfactory' named entity 'COVID-19' named entity 'COVID-19' named entity 'COVID-19' named entity 'COVID' named entity 'sense of smell'

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