About: Chapter 4 Molecular Modeling of Major Structural Protein Genes of Avian Coronavirus: Infectious Bronchitis Virus Mass H120 and Italy02 Strains

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About: Chapter 4 Molecular Modeling of Major Structural Protein Genes of Avian Coronavirus: Infectious Bronchitis Virus Mass H120 and Italy02 Strains Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Chapter 4 Molecular Modeling of Major Structural Protein Genes of Avian Coronavirus: Infectious Bronchitis Virus Mass H120 and Italy02 Strains
Creator	Khataby, Khadija Loutfi, Chafiqa Kasmi, Yassine Souiri, Amal Mustapha, Moulay
Source	Elsevier; PMC
abstract	Abstract In Morocco, the epidemiological situation of infectious bronchitis virus (IBV) is very complex, because of the antigenic diversity associated with the emergence of new serotypes/genotypes and variants. The IBV strains circulating in poultry farms are serotypes/genotypes Italy02 and Massachusetts (Mass) identified during 2010–14. The appearance of these variants hinders the prophylactic strategy carried out by the breeders of the Moroccan poultry farm. To solve this problem, we have opted for the rational design of candidate vaccines in order to study the structure of the three-dimensional (3D) S1 spicule protein of serotype Italy02 and Mass H120, through molecular modeling, using the I-TASSER server, then the COACH, and another Meta server to determine and predict the common immunogenic active sites between these two IBV strains circulating in Morocco. The obtained results showed that the two strains studied had identical spatial conformation of the S1 protein structure with a similarity percentage of 81% and an average stability of the modeled sequences. Thus both serotypes share active antigenic sites common in the hypervariable region, located at residues 229, 230, 232, 233, and 235, with a magnesium molecule association around the Alanine 280 region responsible for stimulating immunogenicity. The quality of the 3D conformation, the stability, and the percentage make it possible to have accessibility to the common predicted neutralizing epitopes. Based on these data, we can conclude that it is highly probable that the H120 vaccine strain confers cross-protection against a challenge with new strains Italy02 circulating in Morocco.
has issue date	2020-12-31(xsd:dateTime)
bibo:doi	10.1016/b978-0-12-814966-9.00004-4
has license	els-covid
sha1sum (hex)	a123e8abb706d839b3b9c2cb0d7bb1229d406c1d
schema:url	https://doi.org/10.1016/b978-0-12-814966-9.00004-4
resource representing a document's title	Chapter 4 Molecular Modeling of Major Structural Protein Genes of Avian Coronavirus: Infectious Bronchitis Virus Mass H120 and Italy02 Strains
has PubMed Central identifier	PMC7149332
schema:publication	Emerging and Reemerging Viral Pathogens
resource representing a document's body	covid:a123e8abb706d839b3b9c2cb0d7bb1229d406c1d#body_text
is schema:about of	named entity 'GENES' named entity 'STRUCTURAL PROTEIN' named entity 'STRAINS' named entity 'Molecular' named entity 'Genes' named entity 'INFECTIOUS BRONCHITIS VIRUS' named entity 'MAJOR' named entity 'PROTEIN ' named entity 'MOLECULAR MODELING' named entity 'AVIAN CORONAVIRUS' named entity 'MASS' named entity 'Major' named entity 'Avian Coronavirus' named entity 'hypervariable regions' named entity '3D structure' named entity 'cytolysis' named entity 'Homology modeling' named entity 'protein' named entity 'antigenic' named entity 'amino acids' named entity 'Coronaviridae' named entity 'antigen' named entity '3.5' named entity 'torsion angle' named entity 'lymphokines' named entity 'epitopes' named entity 'virus genome' named entity 'protein' named entity '4.3' named entity 'epizootic' named entity 'Conformation' named entity 'magnesium' named entity 'alpha helices' named entity 'ab initio' named entity 'protein' named entity 'cell adhesion' named entity 'vaccination' named entity 'hypervariable regions' named entity 'torsional angle' named entity 'IBV' named entity 'hypervariable region' named entity 'epitopes' named entity 'antigenic' named entity '3D structure' named entity 'ab initio methods' named entity 'active sites' named entity 'TM-score' named entity 'Morocco' named entity 'genotypes' named entity 'conformation' named entity 'lymphocyte' named entity 'viral genome' named entity 'active sites' named entity 'set of proteins' named entity 'pathogenicity' named entity 'hypervariable region' named entity 'magnesium' named entity 'viral particle' named entity 'vaccine strain' named entity 'secondary structure' named entity 'virulence' named entity 'chemical shift' named entity 'immunogenic' named entity 'serotypes' named entity 'conformation' named entity 'highly contagious' named entity 'IBV' named entity 'RMSD' named entity 'single-stranded RNA' named entity 'immunogenic' named entity 'homology' named entity '4.2' named entity 'RMSD' named entity 'molecular modeling' named entity 'noncovalent bonds' named entity 'immunogenic' named entity '3D structure' named entity 'nucleocapsid protein' named entity 'immune response'

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