About: Application of System Biology to Explore the Association of Neprilysin, Angiotensin-Converting Enzyme 2 (ACE2), and Carbonic Anhydrase (CA) in Pathogenesis of SARS-CoV-2

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About: Application of System Biology to Explore the Association of Neprilysin, Angiotensin-Converting Enzyme 2 (ACE2), and Carbonic Anhydrase (CA) in Pathogenesis of SARS-CoV-2 Goto Sponge NotDistinct Permalink

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Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Application of System Biology to Explore the Association of Neprilysin, Angiotensin-Converting Enzyme 2 (ACE2), and Carbonic Anhydrase (CA) in Pathogenesis of SARS-CoV-2
Creator	Falak, Reza Zolfaghari Emameh, Reza Bahreini, Elham
Source	Medline; PMC
abstract	BACKGROUND: Coronavirus disease 2019 (COVID-19) is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) appears with common symptoms including fever, dry cough, and fatigue, as well as some less common sysmptoms such as loss of taste and smell, diarrhea, skin rashes and discoloration of fingers. COVID-19 patients may also suffer from serious symptoms including shortness of breathing, chest pressure and pain, as well as loss of daily routine habits, pointing out to a sever reduction in the quality of life. COVID-19 has afftected almost all countries, however, the United States contains the highest number of infection (> 1,595,000 cases) and deaths cases (> 95,000 deaths) in the world until May 21, 2020. Finding an influential treatment strategy against COVID-19 can be facilitated through better understanding of the virus pathogenesis and consequently interrupting the biochemical pathways that the virus may play role in human body as the current reservoir of the virus. RESULTS: In this study, we combined system biology and bioinformatic approaches to define the role of coexpression of angiotensin-converting enzyme 2 (ACE2), neprilysin or membrane metallo-endopeptidase (MME), and carbonic anhydrases (CAs) and their association in the pathogenesis of SARS-CoV-2. The results revealed that ACE2 as the cellular attachment site of SARS-CoV-2, neprilysin, and CAs have a great contribution together in the renin angiotensin system (RAS) and consequently in pathogenesis of SARS-CoV-2 in the vital organs such as respiratory, renal, and blood circulation systems. Any disorder in neprilysin, ACE2, and CAs can lead to increase of CO(2) concentration in blood and respiratory acidosis, induction of pulmonary edema and heart and renal failures. CONCLUSIONS: Due to the presence of ACE2-Neprilysin-CA complex in most of vital organs and as a receptor of COVID-19, it is expected that most organs are affected by SARS-CoV-2 such as inflammation and fibrosis of lungs, which may conversely affect their vital functions, temporary or permanently, sometimes leading to death. Therefore, ACE2-Neprilysin-CA complex could be the key factor of pathogenesis of SARS-CoV-2 and may provide us useful information to find better provocative and therapeutic strategies against COVID-19.
has issue date	2020-06-19(xsd:dateTime)
bibo:doi	10.1186/s12575-020-00124-6
bibo:pmid	32572334
has license	cc-by
sha1sum (hex)	a15d7dd644a3df22339f03bbe7bd2107c1cb77b8
schema:url	https://doi.org/10.1186/s12575-020-00124-6
resource representing a document's title	Application of System Biology to Explore the Association of Neprilysin, Angiotensin-Converting Enzyme 2 (ACE2), and Carbonic Anhydrase (CA) in Pathogenesis of SARS-CoV-2
has PubMed Central identifier	PMC7302923
has PubMed identifier	32572334
schema:publication	Biol Proced Online
resource representing a document's body	covid:a15d7dd644a3df22339f03bbe7bd2107c1cb77b8#body_text
is schema:about of	named entity 'sever' named entity 'renal' named entity 'fingers' named entity 'pathogenesis' named entity 'virus' named entity 'SARS-CoV-2' named entity 'bioinformatic' named entity 'Converting' named entity 'HABITS' named entity 'LUNGS' named entity 'DEATH' named entity 'CAUSED BY' named entity 'FACTOR' named entity 'BREATHING' named entity 'LOSS OF' named entity 'THEIR' named entity 'BETTER' named entity 'DUE TO' named entity 'CURRENT' named entity 'USEFUL INFORMATION' named entity 'AFFECTED' named entity 'ALMOST ALL' named entity 'RENAL' named entity 'UNITED STATES' named entity 'VIRUS' named entity 'DRY COUGH' named entity 'REVEALED' named entity 'PATHWAYS' named entity 'INTERRUPTING' covid:arg/a15d7dd644a3df22339f03bbe7bd2107c1cb77b8 named entity 'May 21' named entity 'induction' named entity 'ACE2' named entity 'conversely' named entity 'system' named entity 'virus' named entity 'factor' named entity 'organs' named entity 'cases' named entity 'failures' named entity 'human body' named entity 'combined' named entity 'vital organs' named entity 'taste' named entity 'life' named entity 'Due' named entity 'systems' named entity 'leading' named entity 'ACE2' named entity 'loss of taste' named entity 'United States' named entity 'angiotensin-converting enzyme 2' named entity 'diarrhea' named entity 'COVID-19' named entity 'lungs' named entity 'MME' named entity 'fibrosis' named entity 'membrane metallo-endopeptidase' named entity 'Neprilysin' named entity 'chest pressure' named entity 'ACE2' named entity 'neprilysin' named entity 'fever' named entity 'Pathogenesis' named entity 'Carbonic Anhydrase' named entity 'ACE2' named entity 'depression' named entity 'ACE2' named entity 'prevalence rate' named entity 'hypertension' named entity 'genes expression' named entity 'attenuate' named entity 'catalyzes' named entity 'angiotensin' named entity 'ACE2' named entity 'ACE2' named entity 'virus' named entity 'vaccinology' named entity 'type II'

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