About: Involvement of fat mass and obesity gene (FTO) in the anti-obesity action of Annona muricata Annonaceae: in silico and in vivo studies

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About: Involvement of fat mass and obesity gene (FTO) in the anti-obesity action of Annona muricata Annonaceae: in silico and in vivo studies Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Involvement of fat mass and obesity gene (FTO) in the anti-obesity action of Annona muricata Annonaceae: in silico and in vivo studies
Creator	Akeem, & Courage, & Ejelonu, Cecilia Famusiwa, Dele Lawal, Olalekan Molehin, Raphael Olalekan Elekofehinti, Olusola Olorunfemi, & Oluwamodupe, &
Source	PMC
abstract	BACKGROUND: Annona muricata (Annonaceae) known as soursop is a common tropical plant species known for its numerous medicinal properties including obesity. The underlying mechanism of anti-obesity effect of A. muricata was investigated. The fat mass and obesity associated protein (FTO) is a validated potential target for anti-obesity drugs. METHODS: The interaction of compounds previously characterized from A. muricata was investigated against FTO using Autodock Vina. Also, modulation of FTO and STAT-3 mRNA expression by A. muricata was investigated in high fat diet induced obese rats (HFDR) using RT-PCR. RESULTS: A significant up-regulation of FTO gene was observed in HFDR when compared to control rats, while administration of A. muricata (200 mg/kg) significantly (p < 0.05) down-regulated FTO gene expression when compared to HFDR group. The effect of obesity on STAT-3 gene expression was also reversed by A. muricata (200 mg/kg). In silico study revealed annonaine and annonioside (−9.2 kcal/mol) exhibited the highest binding affinity with FTO, followed by anonaine and isolaureline (−8.6 kcal/mol). Arg-96 is a critical amino acid enhancing anonaine, isolaureline-FTO binding. CONCLUSION: This study suggests the possible anti-obesity mechanism of A. muricata is via down-regulation of FTO with concomitant up-regulation of STAT-3 genes. This study confirmed the use of this plant in the management of obesity and the probable compounds responsible for its antiobesity effect are annonaine and annonioside.
has issue date	2020-03-12(xsd:dateTime)
bibo:doi	10.1007/s40200-020-00491-7
bibo:pmid	32420297
has license	no-cc
sha1sum (hex)	a1803e22f12c7faa0e718d80394b8a31e10f5539
schema:url	https://doi.org/10.1007/s40200-020-00491-7
resource representing a document's title	Involvement of fat mass and obesity gene (FTO) in the anti-obesity action of Annona muricata Annonaceae: in silico and in vivo studies
has PubMed Central identifier	PMC7223953
has PubMed identifier	32420297
schema:publication	J Diabetes Metab Disord
resource representing a document's body	covid:a1803e22f12c7faa0e718d80394b8a31e10f5539#body_text
is schema:about of	named entity 'In silico' named entity 'A. muricata' named entity 'interaction' named entity 'A. muricata' named entity 'obesity' named entity 'mRNA' named entity 'mol' named entity 'A. muricata' named entity 'vivo' named entity 'EFFECT' named entity 'CRITICAL' named entity 'STAT' named entity 'SIGNIFICANT' named entity 'FTO' named entity 'USE OF' named entity 'OBESE' named entity 'KCAL' named entity 'A COMMON' named entity 'PROPERTIES' named entity 'STUDY' named entity 'ANONAINE' named entity 'INDUCED' named entity '0.05' named entity 'INTERACTION' named entity 'FTO GENE' named entity 'CONCOMITANT' named entity 'ENHANCING' covid:arg/a1803e22f12c7faa0e718d80394b8a31e10f5539 named entity 'probable' named entity 'binding energies' named entity 'A. muricata' named entity 'cardiovascular diseases' named entity 'filter paper' named entity 'control group' named entity 'energy homeostasis' named entity 'amino acid residues' named entity 'control group' named entity 'reverse transcription polymerase chain reaction' named entity 'Department of Biochemistry' named entity 'drug targets' named entity 'down-regulated' named entity 'pancreas' named entity 'drugs' named entity 'common' named entity 'critical' named entity 'anti-obesity' named entity 'growth factors' named entity 'obese' named entity 'distilled water' named entity 'gene' named entity 'food intake' named entity 'antiparasitic' named entity 'downregulation' named entity 'obesity' named entity 'obesity' named entity 'A. muricata' named entity 'Tris base' named entity 'fat mass' named entity 'kcal' named entity 'statistical difference' named entity 'developed nations' named entity 'antidiabetic' named entity 'milliliters' named entity 'FTO gene' named entity 'protein' named entity 'electrophoresed' named entity 'up-regulation' named entity 'anti-obesity' named entity 'study' named entity 'Annona' named entity 'Autodock Vina' named entity 'soursop' named entity 'down-regulation'

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