About: Challenge infection model for MERS-CoV based on naturally infected camels

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About: Challenge infection model for MERS-CoV based on naturally infected camels Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Challenge infection model for MERS-CoV based on naturally infected camels
Creator	Balkhy, Hanan Alkarar, Ali Bayoumi, Faisal Kasem, Samy Qasim, Ibrahim Al-Abdely, Hail Albrahim, Raed Aldowerij, Ali Aldubaib, Musaad Alhafufi, Ali Almansour, Ali Ibrahim, Osman Abu-Obaidah, Ali Khalaf, Naif
Source	Medline; PMC
abstract	BACKGROUND: Middle East Respiratory Syndrome coronavirus (MERS-CoV) is an emerging virus that infects humans and camels with no approved antiviral therapy or vaccine. Some vaccines are in development for camels as a one-health intervention where vaccinating camels is proposed to reduce human viral exposure. This intervention will require an understanding of the prior exposure of camels to the virus and appropriate vaccine efficacy studies in camels. METHODS: We conducted a cross sectional seroprevalence study in young dromedary camels to determine the rate of MERS-CoV seropositivity in young camels. Next, we utilised naturally infected camels as a natural challenge model that can be used by co-housing these camels with healthy naive camels in a ratio of 1 to 2. This model is aimed to support studies on natural virus transmission as well as evaluating drug and vaccine efficacy. RESULTS: We found that 90% of the screened camels have pre-existing antibodies for MERS-CoV. In addition, the challenge model resulted in MERS-CoV transmission within 48 h with infections that continued for 14 days post challenge. CONCLUSIONS: Our finding suggests that the majority of young dromedary camels in Saudi Arabia are seropositive and that naturally infected camels can serve as a challenge model to assess transmission, therapeutics, and vaccine efficacy.
has issue date	2020-06-17(xsd:dateTime)
bibo:doi	10.1186/s12985-020-01347-5
bibo:pmid	32552831
has license	cc-by
sha1sum (hex)	a1ea7d7e09b6072c72396b6fbb20dd1cfcb3e266
schema:url	https://doi.org/10.1186/s12985-020-01347-5
resource representing a document's title	Challenge infection model for MERS-CoV based on naturally infected camels
has PubMed Central identifier	PMC7298446
has PubMed identifier	32552831
schema:publication	Virol J
resource representing a document's body	covid:a1ea7d7e09b6072c72396b6fbb20dd1cfcb3e266#body_text
is schema:about of	named entity 'virus' named entity 'ratio' named entity 'Next' named entity 'Background' named entity 'efficacy' named entity 'camels' named entity 'camels' named entity 'infected' covid:arg/a1ea7d7e09b6072c72396b6fbb20dd1cfcb3e266 named entity 'cross sectional' named entity 'humans' named entity 'model' named entity 'vaccine' named entity 'naive' named entity 'dromedary' named entity 'vaccine' named entity 'viral' named entity 'model' named entity 'This' named entity 'Methods' named entity 'one-health' named entity 'virus' named entity 'dromedary camels' named entity 'MERS-CoV' named entity 'virus' named entity 'antibodies' named entity 'infection' named entity 'dromedaries' named entity 'MERS-CoV' named entity 'vaccine studies' named entity 'MERS-CoV' named entity 'SEPCO' named entity 'Republic of Korea' named entity 'virus' named entity 'adenoviral' named entity 'MERS-CoV' named entity 'endemic' named entity 'infection' named entity 'Hajj' named entity '1.1' named entity 'provinces of Saudi Arabia' named entity 'viral RNA' named entity 'virus' named entity 'Dromedaries' named entity 'placebo' named entity 'MERS-CoV' named entity 'camel' named entity 'infection' named entity 'RNA' named entity 'seroconverted' named entity 'seroprevalence' named entity 'gene' named entity 'virus' named entity 'Makkah' named entity 'seroprevalence' named entity 'KSA' named entity 'seropositive' named entity 'virus' named entity 'seropositive' named entity 'Virus' named entity 'infectious dose' named entity 'dromedary camels' named entity 'camel' named entity 'Makkah province' named entity 'dromedaries' named entity 'infection control' named entity 'Saudi Arabia' named entity 'seroprevalence'

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