About: Transmission Kinetics and histopathology induced by European Turkey Coronavirus during experimental infection of specific pathogen free turkeys

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Transmission Kinetics and histopathology induced by European Turkey Coronavirus during experimental infection of specific pathogen free turkeys
Creator	Rose, Nicolas Brown, Paul Brown, Verheije, Monique Weerts, Erik Correspondence, Paul Courtillon, Céline Eterradossi, Nicolas Allée, \| Amelot, Michel Mathieu, \| Vendembeuche, Anthony
source	Medline; PMC
abstract	Numerous viruses, mostly in mixed infections, have been associated worldwide with poult enteritis complex (PEC). In 2008 a coronavirus (Fr‐TCoV 080385d) was isolated in France from turkey poults exhibiting clinical signs compatible with this syndrome. In the present study, the median infectious dose (ID (50))(,) transmission kinetics and pathogenicity of Fr‐TCoV were investigated in 10‐day‐old SPF turkeys. Results revealed a titre of 10(4.88) ID (50)/ml with 1 ID (50)/ml being beyond the limit of genome detection using a well‐characterized qRT‐PCR for avian coronaviruses. Horizontal transmission of the virus via the airborne route was not observed however, via the oro‐faecal route this proved to be extremely rapid (one infectious individual infecting another every 2.5 hr) and infectious virus was excreted for at least 6 weeks in several birds. Histological examination of different zones of the intestinal tract of the Fr‐TCoV‐infected turkeys showed that the virus had a preference for the lower part of the intestinal tract with an abundance of viral antigen being present in epithelial cells of the ileum, caecum and bursa of Fabricius. Viral antigen was also detected in dendritic cells, monocytes and macrophages in these areas, which may indicate a potential for Fr‐TCoV to replicate in antigen‐presenting cells. Together these results highlight the importance of good sanitary practices in turkey farms to avoid introducing minute amounts of virus that could suffice to initiate an outbreak, and the need to consider that infected individuals may still be infectious long after a clinical episode, to avoid virus dissemination through the movements of apparently recovered birds.
has issue date	2018-09-10(xsd:dateTime)
bibo:doi	10.1111/tbed.13006
bibo:pmid	30146717
has license	no-cc
sha1sum (hex)	a20c64d86e24346f67607db93d49722bea44c615
schema:url	https://doi.org/10.1111/tbed.13006
resource representing a document's title	Transmission Kinetics and histopathology induced by European Turkey Coronavirus during experimental infection of specific pathogen free turkeys
has PubMed Central identifier	PMC7138094
has PubMed identifier	30146717
schema:publication	Transbound Emerg Dis
resource representing a document's body	covid:a20c64d86e24346f67607db93d49722bea44c615#body_text
is schema:about of	named entity 'France' named entity 'qRT-PCR' named entity 'coronavirus' named entity 'turkey' named entity 'Transmission' named entity 'DETECTED' named entity 'OUTBREAK' named entity 'GENOME' named entity 'POTENTIAL' named entity 'COMPATIBLE WITH' named entity 'USING' named entity 'HISTOLOGICAL EXAMINATION' named entity 'INFECTED' named entity 'ASSOCIATED' named entity 'INFECTIONS' named entity 'PRACTICES' named entity 'VIRAL ANTIGEN' named entity 'BURSA OF FABRICIUS' named entity 'RESULTS' covid:arg/a20c64d86e24346f67607db93d49722bea44c615 named entity 'antigen' named entity 'clinical signs' named entity 'virus' named entity 'bursa' named entity 'highlight' named entity 'antigen' named entity 'turkeys' named entity 'oro-faecal route' named entity 'infection' named entity 'turkey poults' named entity 'airborne route' named entity 'clinical signs' named entity 'turkeys' named entity 'kinetics' named entity 'macrophages' named entity 'antigen' named entity 'dendritic cells' named entity 'qRT-PCR' named entity 'SPF' named entity 'antigen' named entity 'monocytes' named entity 'ileum' named entity 'virus' named entity 'bursa of Fabricius' named entity 'specific pathogen free' named entity 'animal experiments' named entity 'France' named entity 'tissue culture' named entity 'oral route' named entity 'infection' named entity 'TCoV' named entity 'TCoV' named entity 'RNA' named entity 'atrophy' named entity 'turkeys' named entity 'inoculate' named entity 'intestines' named entity 'virus' named entity 'microliter' named entity 'turkeys' named entity 'histopathological' named entity 'viral RNA' named entity 'bursa of Fabricius' named entity 'oral route' named entity 'infection' named entity 'duodenum' named entity 'Jackwood' named entity 'horizontal transmission' named entity 'excretion' named entity 'Infection'

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