About: Clinical characteristics and outcomes of critically ill patients with novel coronavirus infectious disease (COVID-19) in China: a retrospective multicenter study

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About: Clinical characteristics and outcomes of critically ill patients with novel coronavirus infectious disease (COVID-19) in China: a retrospective multicenter study Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Clinical characteristics and outcomes of critically ill patients with novel coronavirus infectious disease (COVID-19) in China: a retrospective multicenter study
Creator	Yang, Yi Kang, Hanyujie Tong, Zhaohui Wang, Yishan Li, Jinxiu Zhang, Wei Du, Bin Hu, Yu Hu, Ming Jiang, Li Qiu, Haibo Wu, Wenjuan Xie, Jianfeng Zhong, Ming Li, Xuyan Li, Shusheng Zheng, Ruiqiang Huang, Tingrong Huang, Yingzi Pan, Chun Sang, Ling Zheng, Xia Zheng, Kun
source	Medline; PMC
abstract	PURPOSE: An ongoing outbreak of coronavirus disease 2019 (COVID-19) emerged in Wuhan since December 2019 and spread globally. However, information about critically ill patients with COVID-19 is still limited. We aimed to describe the clinical characteristics and outcomes of critically ill patients with COVID-19 and figure out the risk factors of mortality. METHODS: We extracted data retrospectively regarding 733 critically ill adult patients with laboratory-confirmed COVID-19 from 19 hospitals in China through January 1 to February 29, 2020. Demographic data, symptoms, laboratory values, comorbidities, treatments, and clinical outcomes were collected. The primary outcome was 28-day mortality. Data were compared between survivors and non-survivors. RESULTS: Of the 733 patients included in the study, the median (IQR) age was 65 (56–73) years and 256 (34.9%) were female. Among these patients, the median (IQR) APACHE II score was 10 (7 to 14) and 28-day mortality was 53.8%. Respiratory failure was the most common organ failure (597 [81.5%]), followed by shock (20%), thrombocytopenia (18.8%), central nervous system (8.6%) and renal dysfunction (8%). Multivariate Cox regression analysis showed that older age, malignancies, high APACHE II score, high d-dimer level, low PaO(2)/FiO(2) level, high creatinine level, high hscTnI level and low albumin level were independent risk factors of 28-day mortality in critically ill patients with COVID-19. CONCLUSION: In this case series of critically ill patients with COVID-19 who were admitted into the ICU, more than half patients died at day 28. The higher percentage of organ failure in these patients indicated a significant demand for critical care resources. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s00134-020-06211-2) contains supplementary material, which is available to authorized users.
has issue date	2020-08-20(xsd:dateTime)
bibo:doi	10.1007/s00134-020-06211-2
bibo:pmid	32816098
has license	no-cc
sha1sum (hex)	a2142a8755973966ae55fdd2f70917f32ed6bc09
schema:url	https://doi.org/10.1007/s00134-020-06211-2
resource representing a document's title	Clinical characteristics and outcomes of critically ill patients with novel coronavirus infectious disease (COVID-19) in China: a retrospective multicenter study
has PubMed Central identifier	PMC7439240
has PubMed identifier	32816098
schema:publication	Intensive Care Med
resource representing a document's body	covid:a2142a8755973966ae55fdd2f70917f32ed6bc09#body_text
is schema:about of	named entity 'globally' named entity '2019' named entity 'infectious disease' named entity 'ABOUT' named entity 'RISK FACTORS' named entity 'WUHAN' named entity 'ongoing' named entity 'coronavirus disease 2019' named entity 'patients' named entity 'Wuhan' named entity 'COVID' named entity 'critically ill patients' named entity 'risk factors' named entity 'coronavirus' named entity 'pneumonia' named entity 'organ dysfunction' named entity 'mortality rate' named entity 'critically ill patients' named entity 'creatinine' named entity 'multiple organ dysfunction' named entity 'virus' named entity 'critically ill patients' named entity 'endotracheal intubation' named entity 'ICU' named entity 'risk factors' named entity 'laboratory tests' named entity 'renal function' named entity 'missing data' named entity 'ICU' named entity 'INR' named entity 'hsCRP' named entity 'pneumonia' named entity 'critically ill patients' named entity 'acute renal failure' named entity 'IMV' named entity 'risk factor' named entity 'critically ill patients' named entity 'Severity of illness' named entity 'Kaplan-Meier' named entity 'organ failure' named entity 'COVID' named entity 'd-dimer' named entity 'continuous renal replacement therapy' named entity 'hypoxemia' named entity 'd-dimer' named entity 'low albumin' named entity 'informed consent' named entity 'type 2' named entity 'follow-up' named entity 'laboratory tests' named entity '95% confidence interval' named entity 'organ dysfunction' named entity 'risk factors' named entity 'mechanical ventilation' named entity 'Shenzhen' named entity 'arterial blood gas' named entity 'severe respiratory failure' named entity 'vasopressors' named entity 'd-dimer'

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