About: Astroglial IFITM3 mediates neuronal impairments following neonatal immune challenge in mice

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About: Astroglial IFITM3 mediates neuronal impairments following neonatal immune challenge in mice Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Astroglial IFITM3 mediates neuronal impairments following neonatal immune challenge in mice
Creator	Nabeshima, Toshitaka Ibi, Daisuke Yamada, Kiyofumi Nagai, Taku Mizoguchi, Hiroyuki Adams, David Lange, Ulrike Hayakawa, Masahiro Kaibuchi, Kozo Kawase, Takahiro Nakajima, Akira Sato, Yoshiaki Satoh, Takaya Sawa, Akira Tsuboi, Daisuke Kano, Shin-Ichi Surani, M
source	Medline; PMC
abstract	Interferon‐induced transmembrane protein 3 (IFITM3) ıplays a crucial role in the antiviral responses of Type I interferons (IFNs). The role of IFITM3 in the central nervous system (CNS) is, however, largely unknown, despite the fact that its expression is increased in the brains of patients with neurologic and neuropsychiatric diseases. Here, we show the role of IFITM3 in long‐lasting neuronal impairments in mice following polyriboinosinic‐polyribocytidylic acid (polyI:C, a synthetic double‐stranded RNA)‐induced immune challenge during the early stages of development. We found that the induction of IFITM3 expression in the brain of mice treated with polyI:C was observed only in astrocytes. Cultured astrocytes were activated by polyI:C treatment, leading to an increase in the mRNA levels of inflammatory cytokines as well as Ifitm3. When cultured neurons were treated with the conditioned medium of polyI:C‐treated astrocytes (polyI:C‐ACM), neurite development was impaired. These polyI:C‐ACM‐induced neurodevelopmental abnormalities were alleviated by ifitm3(−/−) astrocyte‐conditioned medium. Furthermore, decreases of MAP2 expression, spine density, and dendrite complexity in the frontal cortex as well as memory impairment were evident in polyI:C‐treated wild‐type mice, but such neuronal impairments were not observed in ifitm3(−)(/)(−) mice. We also found that IFITM3 proteins were localized to the early endosomes of astrocytes following polyI:C treatment and reduced endocytic activity. These findings suggest that the induction of IFITM3 expression in astrocytes by the activation of the innate immune system during the early stages of development has non‐cell autonomous effects that affect subsequent neurodevelopment, leading to neuropathological impairments and brain dysfunction, by impairing endocytosis in astrocytes. GLIA 2013
has issue date	2013-02-04(xsd:dateTime)
bibo:doi	10.1002/glia.22461
bibo:pmid	23382131
has license	no-cc
sha1sum (hex)	a23ff247c284a68f031304d2b4c99822cb9d0237
schema:url	https://doi.org/10.1002/glia.22461
resource representing a document's title	Astroglial IFITM3 mediates neuronal impairments following neonatal immune challenge in mice
has PubMed Central identifier	PMC7165731
has PubMed identifier	23382131
schema:publication	Glia
resource representing a document's body	covid:a23ff247c284a68f031304d2b4c99822cb9d0237#body_text
is schema:about of	named entity 'neurodevelopment' named entity 'observed' named entity 'mice' named entity 'cytokines' named entity 'effects' named entity 'development' named entity 'Neonatal' named entity 'endocytic' named entity 'Type I interferons (IFNs)' named entity 'astrocytes' named entity 'neuropsychiatric' named entity 'induction' named entity 'early endosomes' named entity 'reduced' named entity 'fact' named entity 'Neuronal' named entity 'endocytic' named entity 'mRNA' named entity 'astrocytes' named entity 'ifitm3' named entity 'IFITM3' named entity 'memory impairment' named entity 'astrocytes' named entity 'mice' named entity 'neuropathological' named entity 'Ifitm3' named entity 'neurons' named entity 'mice' named entity 'IFITM3' named entity 'clathrin-dependent' named entity 'postnatal' named entity 'trypsin' named entity 'dendrite' named entity 'cDNA' named entity 'Alexa Fluor' named entity 'IFN' named entity 'endocytosis' named entity 'IFITM3' named entity 'IFN' named entity 'cytoplasm' named entity 'Sigma-Aldrich' named entity '5.0' named entity 'mRNA' named entity 'dendrite' named entity 'null mutant' named entity 'long-lasting' named entity 'object recognition memory' named entity 'ifitm3' named entity 'pyramidal neurons' named entity 'Sigma-Aldrich' named entity 'neurite' named entity 'protein' named entity 'skim milk' named entity 'IL-1b' named entity 'Real-Time PCR' named entity 'mice' named entity 'astroglial' named entity 'IFITM3' named entity 'Sholl analysis' named entity 'ifitm3' named entity 'cDNA' named entity 'protein' named entity 'antisense' named entity '0.01' named entity 'ifitm3'

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