About: Longitudinal high-throughput TCR repertoire profiling reveals the dynamics of T cell memory formation after mild COVID-19 infection

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: Longitudinal high-throughput TCR repertoire profiling reveals the dynamics of T cell memory formation after mild COVID-19 infection Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Longitudinal high-throughput TCR repertoire profiling reveals the dynamics of T cell memory formation after mild COVID-19 infection
Creator	Franke, Andre Chudakov, Dmitriy Efimov, Grigory Komech, Ekaterina Koraichi, Meriem Lebedev, Yuri Mamedov, Ilgar Minervina, Anastasia Mora, Thierry Pogorelyy, Mikhail Rosati, Elisa Titov, Aleksei Walczak, Aleksandra
Source	ArXiv
abstract	COVID-19 is a global pandemic caused by the SARS-CoV-2 coronavirus. The T cell response is a critical part of both individual and herd immunity to SARS-CoV-2 and the efficacy of developed vaccines. However neither the dynamics and cross-reactivity of the SARS-CoV-2-specific T cell response nor the diversity of resulting immune memory are well understood. In this study we use longitudinal high-throughput T cell receptor sequencing to track changes in the T cell repertoire following two mild cases of COVID-19 infection. In both donors we identified SARS-CoV-2-responding CD4+ and CD8+ T cell clones. We describe characteristic motifs in TCR sequences of COVID-19-reactive clones, suggesting the existence of immunodominant epitopes. We show that in both donors the majority of infection-reactive clonotypes acquire memory phenotypes. Certain CD4+ clones were detected in the memory fraction at the pre-infection timepoint, suggesting participation of pre-existing cross-reactive memory T cells in the immune response to SARS-CoV-2.
has issue date	2020-05-17(xsd:dateTime)
has license	arxiv
sha1sum (hex)	a248dabccad341aaf690023c1cfb91430542e8fb
resource representing a document's title	Longitudinal high-throughput TCR repertoire profiling reveals the dynamics of T cell memory formation after mild COVID-19 infection
resource representing a document's body	covid:a248dabccad341aaf690023c1cfb91430542e8fb#body_text
is schema:about of	named entity 'cases' named entity 'infection' named entity 'MEMORY T CELLS' named entity 'MOTIFS' named entity 'USE' named entity 'EFFICACY' named entity 'IMMUNODOMINANT EPITOPES' named entity 'CD4' named entity 'THROUGHPUT' named entity 'MEMORY FORMATION' named entity 'cross-reactivity' named entity 'T cell' named entity 'receptor' named entity 'specific' named entity 'participation' named entity 'T cell' named entity 'memory T cells' named entity 'arXiv' named entity 'phenotypes' named entity 'developed' named entity 'memory' named entity 'cross-reactivity' named entity 'memory T cells' named entity 'CD8+ T cell' named entity 'vaccines' named entity 'CD4+' named entity 'CD4+' named entity 'SARS-CoV-2' named entity 'COVID' named entity 'immune response' named entity 'infection' named entity 'high-throughput' named entity 'SARS-CoV-2' named entity 'infection' named entity 'SARS-CoV-2' named entity 'IgG' named entity 'amino acid sequences' named entity 'CD4+' named entity 'amino acid sequence' named entity 'PCA' named entity 'immune response' named entity 'ALICE' named entity 'CD45RA' named entity 'immunization' named entity 'CD4+ T cells' named entity 'antibodies' named entity 'COVID' named entity 'phenotype' named entity 'self-quarantine' named entity 'HLA' named entity 'CD8' named entity 'SARS-CoV-2' named entity 'PCR' named entity 'infection' named entity 'RNA' named entity 'live vaccines' named entity 'ALICE' named entity 'negative-binomial' named entity 'CD8+ T cells' named entity '2, 3' named entity 'cDNA libraries' named entity 'SARS-CoV-2' named entity 'RNA' named entity 'immunization' named entity 'cell clones' named entity 'yellow fever' named entity 'SARS-CoV-2' named entity 'CD8+ T cells' named entity '1:400' named entity 'adaptive immune response' named entity 'CD4' named entity 'France' named entity 'cross-reactive' named entity 'cell clones' named entity 'CD4+'

Faceted Search & Find service v1.13.91 as of Mar 24 2020

Alternative Linked Data Documents: Sponger | ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3229 as of Jul 10 2020, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (94 GB total memory)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software