About: Immunostimulatory and anti-metastatic activity of polysaccharides isolated from byproducts of the corn starch industry

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About: Immunostimulatory and anti-metastatic activity of polysaccharides isolated from byproducts of the corn starch industry Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Immunostimulatory and anti-metastatic activity of polysaccharides isolated from byproducts of the corn starch industry
Creator	Kim, Sun Lee, Ho Lee, Sue Shin, Kwang-Soon
Source	Elsevier; Medline; PMC
abstract	Abstract Corn steep liquor (CSL) is a major by-product of the corn steeping process that is utilized in the wet milling industry. To develop new physiologically active polysaccharides from CSL, polysaccharides were isolated and their innate immunostimulatory and anti-metastatic activities were investigated. Corn byproduct polysaccharides (CBP) were preferentially isolated from CSL and further separated into supernatant (CBP1S) and precipitate (CBP1P) fractions. The anti-complementary activity of CBP1S was more potent than CBP1P and CBP. In addition, CBP1S enhanced production of macrophage-stimulating cytokines (e.g., IL-6 and IL-12) and natural killer (NK) cell-activating substances (e.g., granzyme and interferon-γ). Further, CBP1S significantly inhibited lung metastasis at a dose of 1000μg per mouse in an experimental lung metastasis model. These results suggest that CBP1S seems to promote the inhibition of lung metastasis through a mechanism leading to stimulation of the innate immune system, and CBP1S could be used as immunostimulating agents and for industrial applications.
has issue date	2018-02-01(xsd:dateTime)
bibo:doi	10.1016/j.carbpol.2017.11.060
bibo:pmid	29254053
has license	els-covid
sha1sum (hex)	a2bdb18937601c65ee4cc21c4b6a2c89e1fe7527
schema:url	https://doi.org/10.1016/j.carbpol.2017.11.060
resource representing a document's title	Immunostimulatory and anti-metastatic activity of polysaccharides isolated from byproducts of the corn starch industry
has PubMed Central identifier	PMC7112432
has PubMed identifier	29254053
schema:publication	Carbohydrate Polymers
resource representing a document's body	covid:a2bdb18937601c65ee4cc21c4b6a2c89e1fe7527#body_text
is schema:about of	named entity 'ANTI-METASTATIC ACTIVITY' named entity 'INDUSTRY' named entity 'POLYSACCHARIDES' named entity 'THESE' named entity 'ACTIVITIES' named entity 'EXPERIMENTAL' named entity 'CBP' named entity '1000' named entity 'SUBSTANCES' named entity 'STEEPING' named entity 'GRANZYME' named entity 'INDUSTRY' named entity 'MODEL' named entity 'ADDITION' named entity 'METASTATIC' named entity 'INVESTIGATED' covid:arg/a2bdb18937601c65ee4cc21c4b6a2c89e1fe7527 named entity 'ACTIVATING' named entity 'USED' named entity 'MACROPHAGE' named entity 'LUNG METASTASIS' named entity 'RESULTS' named entity 'CELL' named entity 'NATURAL KILLER' named entity 'IL-12' named entity 'A MAJOR' named entity 'INNATE IMMUNE SYSTEM' named entity 'INHIBITION' named entity 'DOSE' named entity 'BCG' named entity 'STIMULATING' named entity 'ENHANCED' named entity 'PRECIPITATE' named entity 'LEADING' named entity 'ACTIVE' named entity 'INHIBITED' named entity 'CORN STEEP LIQUOR' named entity 'PRODUCTION' named entity 'COULD BE' named entity 'FRACTIONS' named entity 'BY-PRODUCT' named entity 'PROMOTE' named entity 'SUGGEST' named entity 'SEPARATED' named entity 'ANTI-COMPLEMENTARY ACTIVITY' named entity 'MOUSE' named entity 'CORN STARCH' named entity 'ISOLATED' named entity 'MECHANISM' named entity 'IL-6' named entity 'IS A' named entity 'CYTOKINES' named entity 'NEW' named entity 'CORN' named entity 'CSL' named entity 'STIMULATION' named entity 'INTERFERON' named entity 'PROCESS' named entity 'INDUSTRIAL APPLICATIONS' named entity 'WET' named entity 'SUPERNATANT' named entity 'POLYSACCHARIDES' named entity 'MILLING' named entity 'ISOLATED' named entity 'THEIR' named entity 'Corn steep liquor' named entity 'innate immune' named entity 'lung' named entity 'polysaccharides' named entity 'granzyme' named entity 'NK cell' named entity 'NHS' named entity 'Kyonggi University' named entity 'polysaccharides' named entity 'brix' named entity 'alditol' named entity 'corn' named entity 'CSL'

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